Coblation versus Unipolar Electrocautery Tonsillectomy: A Prospective, Randomized, Single-Blind Study in Adult Patients

Control of nausea and vomiting is very important in determining patient compliance with cisplatin chemotherapy. A multicentre, randomized, single-blind study was conducted to compare the tolerability and efficacy of ramosetron with those of granisetron over 24 h following cisplatin administration to cancer patients. In eight study centres, a total of 194 adult patients were randomly assigned to receive either intravenous ramosetron 0.3 mg or intravenous granisetron 3.0 mg. The anti-emetic effect of ramosetron determined from the no-vomiting rate lasted longer, but there was no significant difference in the number of acute vomiting episodes or the severity of nausea between the two groups. In the tolerability evaluation, there were no statistically significant differences between the two groups, except for a higher incidence of dull headache in the granisetron group. Ramosetron and granisetron appear to have equivalent efficacy and tolerability profiles, but the effects of ramosetron on the prevention of acute vomiting in patients undergoing cisplatin chemotherapy were longer lasting.

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Influence of Vitamin E on Plasma Malondialdehyde- Like Material in Man

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661098 ◽

1984 ◽

Vol 51 (03) ◽

pp. 347-348 ◽

Cited By ~ 12

Author(s):

C Cordova ◽

A Musca ◽

F Violi ◽

C Alessandri ◽

A Ghiselli ◽

...

Keyword(s):

Vitamin E ◽

Healthy Subjects ◽

Placebo Treatment ◽

Blind Study ◽

Single Blind ◽

Plasma Malondialdehyde

SummaryThe behaviour of plasma malondialdehyde-like material (MDA-LM) was evaluated in 13 healthy subjects by a single-blind study that consisted of placebo (30 days), vitamin E treatment (300 mg/day) (30 days) and placebo (30 days). The study demonstrated that MDA-LM did not change during placebo treatment while it significantly decreased after vitamin E administration.

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Anesthetic Efficacy of a Combination of 0.5 M Mannitol Plus 127.2 mg of Lidocaine With 50 μg Epinephrine in Inferior Alveolar Nerve Blocks: A Prospective Randomized, Single-Blind Study

Anesthesia Progress ◽

10.2344/11-00040.1 ◽

2013 ◽

Vol 60 (1) ◽

pp. 3-10 ◽

Cited By ~ 7

Author(s):

Steven Smith ◽

Al Reader ◽

Melissa Drum ◽

John Nusstein ◽

Mike Beck

Keyword(s):

Postoperative Pain ◽

Inferior Alveolar Nerve ◽

Blind Study ◽

Maximum Output ◽

Nerve Blocks ◽

Posterior Teeth ◽

Solution Deposition ◽

The Times ◽

Pulpal Anesthesia ◽

Single Blind

Abstract The purpose of this prospective, randomized, single-blind study was to determine the anesthetic efficacy of 127.2 mg lidocaine with 50 μg epinephrine compared to 127.2 mg lidocaine with 50 μg epinephrine plus 0.5 M mannitol in inferior alveolar nerve (IAN) blocks. Forty subjects randomly received 2 IAN blocks consisting of a 3.18 mL formulation of 127.2 mg lidocaine with 50 μg epinephrine and a 5 mL formulation of 127.2 mg lidocaine with 50 μg epinephrine (3.18 mL) plus 0.5 M mannitol (1.82 mL) in 2 separate appointments spaced at least 1 week apart. Mandibular anterior and posterior teeth were blindly electric pulp tested at 4-minute cycles for 60 minutes postinjection. Pain of solution deposition and postoperative pain were also measured. No response from the subject to the maximum output (80 reading) of the pulp tester was used as the criterion for pulpal anesthesia. Total percent pulpal anesthesia was defined as the total of all the times of pulpal anesthesia (80 readings) over the 60 minutes. One hundred percent of the subjects had profound lip numbness with both inferior alveolar nerve blocks. The results demonstrated that a 5 mL formulation of 127.2 mg lidocaine with 50 μg epinephrine plus 0.5 M mannitol was significantly better than the 3.18 mL formulation of 127.2 mg lidocaine with 50 μg epinephrine for all teeth. Solution deposition pain and postoperative pain were not statistically different between the lidocaine/mannitol formulation and the lidocaine formulation without mannitol. We concluded that adding 0.5 M mannitol to a lidocaine with epinephrine formulation was significantly more effective in achieving a greater percentage of total pulpal anesthesia than a lidocaine formulation without mannitol.

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A Randomized Single Blind Controlled Trial of Combination Therapy (Spironolactone and Sitagliptin) in Hospitalized Adult Patients with Covid-19

SSRN Electronic Journal ◽

10.2139/ssrn.3889411 ◽

2021 ◽

Author(s):

Kamyar Asadipooya ◽

Farhad Abbasi ◽

Reuben Adatorwovor ◽

Mohammad Ali Davarpanah ◽

Yasaman Mansoori ◽

...

Keyword(s):

Combination Therapy ◽

Controlled Trial ◽

Adult Patients ◽

Single Blind

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Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with rotator cuff tendon tear: A prospective, non-randomized, comparative, single-blind study

Annals of Physical and Rehabilitation Medicine ◽

10.1016/j.rehab.2018.05.169 ◽

2018 ◽

Vol 61 ◽

pp. e79

Author(s):

H.S. Lee ◽

E.K. Kim ◽

S.J. Kim

Keyword(s):

Bone Marrow ◽

Rotator Cuff ◽

Bone Marrow Aspirate ◽

Platelet Rich Plasma ◽

Blind Study ◽

Tendon Tear ◽

Rotator Cuff Tendon ◽

Bone Marrow Aspirate Concentrate ◽

Single Blind

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Study of a New Analgesic Compound in the Treatment of Tension Headache*

Journal of International Medical Research ◽

10.1177/030006057600400112 ◽

1976 ◽

Vol 4 (1) ◽

pp. 74-78 ◽

Cited By ~ 7

Author(s):

J Borges ◽

C Zavaleta

Keyword(s):

Side Effects ◽

Pharmacological Activity ◽

Clinical Success ◽

Tension Headache ◽

Symptomatic Treatment ◽

Blind Study ◽

Effective Combination ◽

Significant Difference ◽

Starting Dose ◽

Single Blind

The effect of a new analgesic compound ( propoxyphene, acetaminophen, caffeine, hydroxyzine) was investigated in a single-blind study comparing it with plain acetaminophen administered to forty patients with tension headache. For the study, patients were assigned to one of two groups of twenty each. Starting dose for each group was one to two tablets followed by one tablet every four to six hours. The results show that 90% clinical success was obtained with the analgesic compound, while a 45% success was obtained with plain acetaminophen. This is a statistically significant difference. Side-effects observed with analgesic compound were primarily drowsiness and dizziness of mild intensity; acetaminophen caused gastro-intestinal alterations ( nausea, vomiting) and dizziness of greater severity. Therapy was withdrawn in 20% of patients taking acetaminophen because of side-effects. The dosage of analgesic compound required to control each episode of tension headache way smaller than that of acetaminophen. These results can be explained by a possible potentiation of pharmacological activity of the compound's components. It can be concluded that the analgesic compound is a new and effective combination for the symptomatic treatment of tension headache.

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