Persistent Generalized Lymphadenopathy (PGL) Mimicking Lymphoma on Whole-Body FDG PET/CT Imaging

2006 ◽  
Vol 31 (7) ◽  
pp. 398-400 ◽  
Author(s):  
Peeyush Bhargava ◽  
Ching-Wen Angela Chang ◽  
Barbara Glickman ◽  
Gabriel Sara ◽  
Munir Ghesani
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
Generalized Lymphadenopathy ◽  
Persistent Generalized Lymphadenopathy ◽  
Fdg Pet Ct

Low positive yield from routine inclusion of the brain in whole-body 18F-FDG PET/CT imaging for noncerebral malignancies

2013 ◽  
Vol 34 (6) ◽  
pp. 540-543 ◽  
Author(s):  
Kuruva Manohar ◽  
Anish Bhattacharya ◽  
Bhagwant R. Mittal
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
The Brain

scholarly journals Leydig cell tumor of the testis: an incidental finding at 18F-FDG PET/CT imaging

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Almalki Yassir
Keyword(s):  
Leydig Cell ◽  
Fdg Pet ◽  
Chronic Rejection ◽  
Ct Imaging ◽  
The Body ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
The Right ◽  
Fdg Pet Ct

Abstract Background Leydig cell tumors (LCTs) represent the most common form of stromal tumors. We reported the 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) findings of a patient with testicular LCT. Case presentation A 50-year-old man with a history of end-stage renal disease and renal transplantation 19 years ago. One year earlier, he started to have a chronic rejection. During the investigation to determine the cause of chronic rejection, a suspicious lesion in the graft with a collection around it was seen on ultrasound (US) images, raising the possibility of post-transplant lymphoproliferative disorder (PTLD). The patient was referred for further evaluation by whole body 18F-FDG PET/CT imaging. The image finding revealed an incidental hypermetabolic focal lesion in the right testicle—no other specific findings in the remaining parts of the body nor definitive FDG avid lymphadenopathy to suggest PTLD. Testicular US was requested and showed a well-defined right-sided heterogeneous hypoechoic intratesticular focal mass at the upper pole of the right testis with significant internal vascularity on the color Doppler imaging. The patient underwent a right radical orchidectomy, and the tumor was pathologically confirmed as an LCT. Conclusion In our case, 18F-FDG-PET/CT has been helpful in incidentally detecting this rare testicular tumor in a patient with suspected PTLD.

Variation of system performance, quality control standards and adherence to international FDG-PET/CT imaging guidelines

2014 ◽  
Vol 53 (06) ◽  
pp. 242-248 ◽  
Author(s):  
H. Bergmann ◽  
B. Geist ◽  
M. Schaffarich ◽  
A. Hirtl ◽  
M. Hacker ◽  
...  
Keyword(s):  
Quality Control ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Public Hospitals ◽  
Whole Body ◽  
Whole Body Imaging ◽  
Glucose Levels ◽  
Pet Ct ◽  
Ct System ◽  
Fdg Pet Ct

Summary Aim: To gather information on clinical operations, quality control (QC) standards and adoption of guidelines for FDG-PET/CT imaging in Austrian PET/CT centres. Methods: A written survey composed of 68 questions related to A) PET/CT centre and installation, B) standard protocol parameters for FDG-PET/CT imaging of oncology patients, and C) standard QC procedures was conducted between November and December 2013 among all Austrian PET/CT centres. In addition, a NEMA-NU2 2012 image quality phantom test was performed using standard whole-body imaging settings on all PET/CT systems with a lesion-to- background ratio of 4. Recovery coefficients (RC) were calculated for each lesion and PET/ CT system. Resu lts: A) 13 PET/CT systems were installed in 12 nuclear medicine departments at public hospitals. B) Average fasting prior to FDG-PET/CT was 7.6 (4-12) h. All sites measured blood glucose levels while using different cut-off levels (64%: 150 mg/dl). Weight- based activity injection was performed at 83% sites with a mean FDG activity of 4.1 MBq/kg. Average FDG uptake time was 55 (45-75) min. All sites employed CT contrast agents (variation from 1 %-95% of the patients). All sites reported SUV-max. C) Frequency of QC tests varied significantly and QC phantom measurements revealed significant differences in RCs. Conclusion: Significant variations in FDG-PET/CT protocol parameters among all Austrian PET/CT users were observed. subsequently, efforts need to be put in place to further standardize imaging protocols. At a minimum clinical PET/CT operations should ensure compliance with existing guidelines. Further, standardized QC procedures must be followed to improve quantitative accuracy across PET/CT centres.

Incidence of non-metastatic extrathoracic lesions detected by whole-body FDG PET-CT imaging in patients with non-small-cell lung cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7186-7186
Author(s):  
D. Lardinois ◽  
H. C. Steinert ◽  
M. Tutic ◽  
G. Görres ◽  
R. Stahel ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Small Cell ◽  
Whole Body ◽  
Small Cell Lung ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals An unusual case of pituitary pathology and the utility of whole body 18F-FDG PET-CT imaging in identifying extraneural biopsy targets

2015 ◽  
Author(s):  
Jenna Deakin ◽  
Michelle Siu ◽  
Harriet Cunningham ◽  
Nikhil Patel ◽  
Thomas Osborne ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Unusual Case ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Multi-modality imaging of uveal melanomas using combined PET/CT, high-resolution PET and MR imaging

2008 ◽  
Vol 47 (02) ◽  
pp. 73-79 ◽  
Author(s):  
U. Pietrzyk ◽  
C. Knoess ◽  
S. Vollmar ◽  
K. Wienhard ◽  
L. Kracht ◽  
...  
Keyword(s):  
High Resolution ◽  
Fdg Pet ◽  
Ct Images ◽  
Ct Imaging ◽  
Whole Body ◽  
Dynamic Mode ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Tumour Activity ◽  
Uveal Melanomas

SummaryWe investigated the efficacy of combined FDG-PET/CT imaging for the diagnosis of small-size uveal melanomas and the feasibility of combining separate, high-resolution (HR) FDG-PET with MRI for its improved localization and detection. Patients, methods: 3 patients with small-size uveal melanomas (0.2–1.5 ml) were imaged on a combined whole-body PET/CT, a HR brain-PET, and a 1.5 T MRI. Static, contrast-enhanced FDG-PET/CT imaging was performed of head and torso with CT contrast enhancement. HR PET imaging was performed in dynamic mode 0–180 min post-injection of FDG. MRI imaging was performed using a high-resolution small-loop-coil placed over the eye in question with T2–3D-TSE and T1–3D-SE with 18 ml Gd-contrast. Patients had their eyes shaded during the scans. Lesion visibility on high-resolution FDGPET images was graded for confidence: 1: none, 2: suggestive, 3: clear. Mean tumour activity was calculated for summed image frames that resulted in confidence grades 2 and 3. Whole-body FDG-PET/CT images were reviewed for lesions. PET-MRI and PET/ CT-MRI images of the head were co-registered for potentially improved lesion delineation. Results: Whole-body FDG-PET/CT images of 3/3 patients were positive for uveal melanomas and negative for disseminated disease. HR FDG-PET was positive already in the early time frames. One patient exhibited rising tumour activity with increasing uptake time on FDG-PET. MRI images of the eye were co-registered successfully to FDG-PET/CT using a manual alignment approach. Conclusions: Small-size uveal melanomas can be detected with whole-body FDG-PET/CT. This feasibility study suggests the exploration of HR FDG-PET in order to provide additional diagnostic information on patients with uveal melanomas. First results support extended uptake times and high-sensitivity PET for improved tumour visibility. MRI/PET co-registration is feasible and provides correlated functional and anatomical information that may support alternative therapy regimens.

scholarly journals Concurrent FDG Avid Nasopharyngeal Lesion and Generalized Lymphadenopathy on PET-CT Imaging Is Indicative of Lymphoma in Patients with HIV Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Yiyan Liu
Keyword(s):  
Hiv Infection ◽  
Fdg Pet ◽  
Clinical Information ◽  
Diagnostic Value ◽  
Ct Imaging ◽  
Positron Emission ◽  
Increased Risk ◽  
Pet Ct ◽  
Generalized Lymphadenopathy ◽  
Fdg Pet Ct

Patients with HIV infection often have generalized lymphadenopathy and/or other lymphoid proliferation and are at significantly increased risk for lymphoma. This study retrospectively evaluated the diagnostic value of concurrent nasopharyngeal lesion and lymphadenopathy on positron emission tomography-computed tomography (PET-CT) with fluorine-18 fluorodeoxyglucose (FDG PET-CT) imaging. The eligible cases were from patients with HIV infection and lymphadenopathy and referred for FDG PET-CT to evaluate lymphoma or other malignancies prior to pathological investigation. FDG PET-CT images and interpretation reports were correlated with clinical information and pathological diagnoses. Among 22 eligible patients, FDG avid nasopharyngeal lesions were incidentally noted in 7 on PET-CT imaging, and all had lymphomas diagnosed with subsequent biopsies (6 diffuse large B-cell lymphomas and 1 Hodgkin’s lymphoma). In the remaining 15 patients with adenopathy but no visible nasopharyngeal lesion or uptake on PET-CT imaging, 9 had biopsies and lymphomas were diagnosed in 4. The patients with FDG avid retroperitoneal or intra-abdominal lymphadenopathy had a greater possibility of lymphoma, compared to those with adenopathy localized only in the upper torso. Coexistent FDG avid nasopharyngeal lesion and generalized lymphadenoapthy on PET-CT imaging are indicative of a malignant lymphoma rather than benign lymphproliferative disease or nasopharyngeal carcinoma.

scholarly journals Pre-Ablation rhTSH-Stimulated F-18 FDG PET/CT Changes Patient Management in Increased-Risk Thyroid Cancer

2020 ◽  
Vol 52 (03) ◽  
pp. 158-167 ◽  
Author(s):  
Gundula Rendl ◽  
Lukas Rettenbacher ◽  
Gregor Schweighofer-Zwink ◽  
Lukas Hehenwarter ◽  
Christian Pirich
Keyword(s):  
Thyroid Cancer ◽  
High Risk ◽  
Fdg Pet ◽  
Patient Management ◽  
Treatment Plan ◽  
Ct Imaging ◽  
Whole Body ◽  
Increased Risk ◽  
Pet Ct ◽  
Fdg Pet Ct

AbstractThe aim of the study was to evaluate the clinical impact of pre-ablation rhTSH-stimulated fluorine-18 fluorodeoxyglucose (F-18 FDG) PET/CT in addition to post-therapeutic whole body radioiodine scanning in patients with intermediate to high risk differentiated thyroid carcinoma (DTC). This was a retrospective single center study including 73 patients with thyroid cancer (44 females, mean age 43.2±16.2 years, 62% papillary, 31% follicular, 7% poorly differentiated). All patients underwent ablative radioiodine treatment (mean activity: 3661±673 MBq I-131) using rhTSH after thyroidectomy and lymph node (LN) dissection (01/2013–10/2016) and TSH-stimulated F-18 FDG PET/CT (4 MBq/kg body weight, low dose CT). Post-treatment I-131 whole body scan (I-131 WBS) was obtained 9 days afterwards in planar technique and in case of equivocal or abnormal findings using SPECT/CT. Thirty-one patients (42%) showed F-18 FDG avid lesions, 14 patients showed more FDG than iodine positive lesions and 5 patients more iodine positive lesions in I-131 WBS, respectively. Fifty-three patients showed identical F-18 FDG PET/CT and I-131 WBS. The initial treatment plan was changed from follow-up to therapy (surgery, systemic therapy using tyrosine-kinase inhibition) in 11 patients (15%) on the basis of F-18 FDG PET/CT imaging. Six of these 11 patients had papillary thyroid cancer. Three patients with histologically proven LN metastases had stimulated thyroglobulin-levels<2.0 ng/ml. Our study demonstrated a clinical benefit of pre-ablation rhTSH-stimulated F-18 FDG PET/CT imaging in about 20% of patients with intermediate to high risk DTC, leading to change in patient management in 15%.

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