A Pilot Study for a Prospective, Randomized, Double-Blind Trial of the Influence of Anesthetic Depth on Long-Term Outcome

2014 ◽  
Vol 58 (5) ◽  
pp. 237-238
Author(s):  
Timothy G. Short ◽  
Kate Leslie ◽  
Douglas Campbell ◽  
Matthew T. V. Chan ◽  
Tomas Corcoran ◽  
...  
Keyword(s):  
Pilot Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Anesthetic Depth ◽  
Blind Trial

A Pilot Study for a Prospective, Randomized, Double-Blind Trial of the Influence of Anesthetic Depth on Long-Term Outcome

2014 ◽  
Vol 118 (5) ◽  
pp. 981-986 ◽  
Author(s):  
Timothy G. Short ◽  
Kate Leslie ◽  
Douglas Campbell ◽  
Matthew T. V. Chan ◽  
Tomas Corcoran ◽  
...  
Keyword(s):  
Pilot Study ◽  
Double Blind Trial ◽  
Double Blind ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Anesthetic Depth ◽  
Blind Trial

scholarly journals Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 994
Author(s):  
Hanne Lademann ◽  
Karl Abshagen ◽  
Anna Janning ◽  
Jan Däbritz ◽  
Dirk Olbertz
Keyword(s):  
Pilot Study ◽  
Preterm Infants ◽  
Perinatal Asphyxia ◽  
Psychomotor Development ◽  
Long Term Outcomes ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Developmental Index ◽  
Mental Developmental Index

Therapeutic hypothermia (THT) is the recommended treatment for neuroprotection in (near) term newborns that experience perinatal asphyxia with hypoxic-ischemic encephalopathy. The benefit of THT in preterm newborns is unknown. This pilot study aims to investigate long-term outcomes of late preterm asphyctic infants with and without THT compared to term infants. The single-center, retrospective analysis examined medical charts of infants with perinatal asphyxia born between 2008 and 2015. Long-term outcome was assessed using the Bayley Scales of Infant Development 2 at the age of (corrected) 24 months. Term (n = 31) and preterm (n = 8) infants with THT showed no differences regarding their long-term outcomes of psychomotor development (Psychomotor Developmental Index 101 ± 16 vs. 105 ± 11, p = 0.570), whereas preterm infants had a better mental outcome (Mental Developmental Index 105 ± 13 vs. 93 ± 18, p = 0.048). Preterm infants with and without (n = 69) THT showed a similar mental and psychomotor development (Mental Developmental Index 105 ± 13 vs. 96 ± 20, p = 0.527; Psychomotor Developmental Index 105 ± 11 vs. 105 ± 15, p = 0.927). The study highlights the importance of studying THT in asphyctic preterm infants. However, this study shows limitations and should not be used as a basis for decision-making in the clinical context. Results of a multicenter trial of THT for preterm infants (ID No.: CN-01540535) have to be awaited.

Early Aneurysm Surgery and Preventive Therapy with Intravenously Administered Nimodipine: A Multicenter, Double-Blind, Dose-Comparison Study

Neurosurgery ◽  
1990 ◽  
Vol 26 (3) ◽  
pp. 458-464 ◽  
Author(s):  
Joachim M. Gilsbach ◽  
Hans J. Reulen ◽  
Bengt Ljunggren ◽  
Lennart Brandt ◽  
Hans v. Holst ◽  
...  
Keyword(s):  
Preventive Therapy ◽  
Neurological Dysfunction ◽  
Comparison Study ◽  
Double Blind ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Dose Comparison ◽  
Significant Difference ◽  
Low Incidence

Abstract A European, multicenter. prospective, randomized. double-blind, dose-comparison study on preventive therapy with intravenously administered nimodipine was performed to evaluate the efficacy and tolerability of two different doses: 2 and 3 mg/h. Two hundred four patients fulfilled the criteria for enrollment in the study; surgery within 72 hours after the last subarachnoid hemorrhage, and age between 16 and 72 years. All patients who had Hunt and Hess grades of I to III were operated upon: patients who had poor Hunt and Hess grades (IV-V) were operated on according to the surgeon's choice. This treatment regimen was associated with a low incidence of delayed neurological dysfunction with no significant difference between the two dosage groups: three patients (1.5%) remained severely disabled and two (1%) moderately disabled due to vasospasm with or without additional complications. Among the patients with Hunt and Hess grades of IV or V. the long-term outcome was favorable (good-fair) for 40% and unfavorable for 60%. Among the patients with grades of I to III, the long-term outcome was favorable for 89% and unfavorable for 11%.

Long-Term Outcome of Panic States During Double-Blind Treatment and After Withdrawal of Alprazolam and Placebo

1992 ◽  
Vol 4 (4) ◽  
pp. 251-258 ◽  
Author(s):  
Stephen Dager ◽  
Peter Roy-Byrne ◽  
Helen Hendrickson ◽  
Deborah Cowley ◽  
David Avery ◽  
...  
Keyword(s):  
Double Blind ◽  
Term Outcome ◽  
Long Term Outcome

Normalization By Suloctidil Of Decreased Platelet Survival In Patients With Heart Prosthetic Valves In Randomized Controlled Double Blind Trial

1981 ◽  
Author(s):  
N Ciavarella ◽  
S Antoneecchit ◽  
N D’Elia ◽  
P Ranieri ◽  
A Manzini
Keyword(s):  
Double Blind Trial ◽  
Anticoagulant Treatment ◽  
Double Blind ◽  
Blind Trial ◽  
Randomized Controlled ◽  
Prosthetic Valves ◽  
Platelet Survival

Platelets play an important role in thromboembo lie episodes in the life of patients with heart prosthetic valves. Decreased platelet survival and increased B-Tromboglobulin and Platelet F4 in the blood are constant features of such condition.45 patients on long term anticoagulant treatment (thrombotest 5-10%),26 males(mean age 46) and 19 females(mean age 44), were studied. 22 normal sub jects served as controls.Platelets survival was studied with MDA production after 5oo mg Aspirin intake and was found signifi canly reduced in patients in comparison to contro Is(p.8.00±1.4 days;c.10.00±1.67 days; P<0.01).BTG and PF4 as measured by RIA were increased (BTG:p.97.8±59 NG/ML;c.29.18±22.40 NG/ML; P<0.01) (PF4:p.36.6±26.5 NG/ML;c.6.29±4.78 NG/ML; P<0.01) The patients were randomly allocated to one of the following groups( 15 subjects each): placebo, Suloctidil 600 mg:die, Suloctidil 1200 mg:die. Duration treatment was 30 days.The effect of Suloctidil was significantly different from that of placebo( P<0.005),as regards Platelet survival without difference between dosa ges of the drug;as concerns BTG and PF4 the chang es under placebo and drug were not different.

Long-Term Outcome of Tubridge Flow Diverter(S) in Treating Large Vertebral Artery Dissecting Aneurysms—A Pilot Study

2016 ◽  
Vol 27 (3) ◽  
pp. 345-350 ◽  
Author(s):  
Y.-B. Fang ◽  
W.-L. Wen ◽  
P.-F. Yang ◽  
Y. Zhou ◽  
Y.-N. Wu ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vertebral Artery ◽  
Flow Diverter ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Dissecting Aneurysms

A Double-Blind Trial of Long-Term Lithium Therapy in Mental Defectives

1974 ◽  
Vol 124 (578) ◽  
pp. 52-57 ◽  
Author(s):  
Graham J. Naylor ◽  
J. M. Donald ◽  
David Le Poidevin ◽  
Andrew H. Reid
Keyword(s):  
Therapeutic Effect ◽  
Affective Disorders ◽  
Lithium Therapy ◽  
Double Blind Trial ◽  
Double Blind ◽  
Blind Trial ◽  
Mental Defectives

The therapeutic effect of lithium in mania was first described by Cade (1949), but the possibility that lithium could have a prophylactic action in recurrent affective disorders was not suggested until some years later (Hartigan, 1963; Baastrup, 1964). The early studies of the prophylactic action of lithium were open trials, in which both investigator and patient knew that the patient was receiving the drug. More recently, controlled double-blind studies have confirmed these early reports (Melia, 1970; Coppenet al., 1971; Cundallet al., 19712).

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