A Soft-Tissue Approach to Midfacial Hypoplasia Associated With Treacher Collins Syndrome

2006 ◽  
Vol 56 (5) ◽  
pp. 522-525 ◽  
Author(s):  
Pierre Saadeh ◽  
Patrick L. Reavey ◽  
John W. Siebert
Keyword(s):  
Soft Tissue ◽  
Treacher Collins Syndrome ◽  
Midfacial Hypoplasia

Cosmetic Considerations of Maxillofacial Dysmorphism

1991 ◽  
Vol 8 (4) ◽  
pp. 223-234
Author(s):  
Charles E. Graper
Keyword(s):  
Soft Tissue ◽  
Cosmetic Surgery ◽  
Aesthetic Surgery ◽  
Diagnosis And Treatment ◽  
Facial Dysmorphism ◽  
Cephalometric Analysis ◽  
Midfacial Hypoplasia

Facial dysmorphogenesis results in cosmetic deformities. Although these deformities may not be initially obvious, they must be carefully identified so that aesthetic surgery may camouflage or restructure them. Cephalometric analysis is used as an aid in the diagnosis of facial dysmorphism. Two cases are presented which discuss midfacial hypoplasia and mandibular deficiency and their surgical resolution with osteoplasty, rhinoplasty, and soft tissue procedures. Principles of diagnosis and treatment applicable to facial cosmetic surgery are illustrated.

scholarly journals New Trends In Treacher Collins Syndrome: Bony Reconstruction And Regenerative Therapy

2021 ◽  
pp. 22
Author(s):  
◽  
Keyword(s):  
Soft Tissue ◽  
De Novo ◽  
Treatment Strategies ◽  
Fat Grafting ◽  
Treacher Collins Syndrome ◽  
Comparative Genomic ◽  
Soft Tissue Reconstruction ◽  
De Novo Mutations ◽  
Differentiation Potential ◽  
Characteristic Appearance

Aim:Treacher Collins syndrome is a rare congenital disorder of craniofacial development with a highly variable pheonotype. This syndrome occurs with an incidence of 1:50,000, and more than 60% of the cases have no previous family history and arise as the result of de novo mutations. The disorder displays an intricate underlying dysmorphology. Affected patients may suffer life-threatening airway complications and functional difficulties involving sight, hearing, speech, and feeding. Deformation of facial structures produces a characteristic appearance that includes malar-zygomatic hypoplasia, periorbital soft tissue anomalies, maxillomandibular hypoplasia, and ear anomalies. Management requires a specialized craniofacial team, as comprehensive care starts at birth and may require life-long follow-up. Standard craniofacial procedures for bony and soft tissue reconstruction are used. This article outlines current treatment strategies and future concepts for surgical and regenerative management. Methods:The new field of regenerative medicine and therapy offers the promise to improve some of these treatments. In particular, Structural Fat Grafting (lipostructure) seems to be a good strategy to restore the normal volume and contour of the face, and to provide a source of adipose-derived stem cells (ADSCs) with a multilineage differentiation potential. In this work, we present the case of a young girl with Treacher Collins Syndrome who underwent serial sessions of fat grafting in addition to other surgical bony reconstructive techniques. ADSCs have been isolated from the patient’s lipoaspirate, and compared for their stemness properties with those of a healthy subject. Conclusion:Screening of the genome of the Treacher Collins patient using array-Comparative Genomic Hybridization (array-CGH) allowed us to identify some chromosomal imbalances that are probably associated with the syndrome.Correction of these imbalances and asymmetries by modulating ADSCs could be an innovative approach to improve and stabilize the results of the surgical treatment of Treacher Collin Syndrome.

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

Morphological Examination of a Herpes-type Virus Indigenous for Tree Shrews

1970 ◽  
Vol 28 ◽  
pp. 160-161
Author(s):  
J. P. Brunschwig ◽  
R. M. McCombs ◽  
R. Mirkovic ◽  
M. Benyesh-Melnick
Keyword(s):  
Electron Microscopy ◽  
Soft Tissue ◽  
Chick Embryo ◽  
Soft Tissue Sarcoma ◽  
Cell Cultures ◽  
Tree Shrew ◽  
Type Virus ◽  
Morphological Examination ◽  
Tree Shrews ◽  
Embryo Cells

A new virus, established as a member of the herpesvirus group by electron microscopy, was isolated from spontaneously degenerating cell cultures derived from the kidneys and lungs of two normal tree shrews. The virus was found to replicate best in cells derived from the homologous species. The cells used were a tree shrew cell line, T-23, which was derived from a spontaneous soft tissue sarcoma. The virus did not multiply or did so poorly for a limited number of passages in human, monkey, rodent, rabbit or chick embryo cells. In the T-23 cells, the virus behaved as members of the subgroup B of herpesvirus, in that the virus remained primarily cell associated.

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