scholarly journals 61 Hypoxia-Inducible Factor 1 (HIF-1) Transcription is a “Signalling Driver” for Allergic Inflammation, Host Innate Immune Defence and Leukaemia Progression

2012 ◽  
Vol 5 ◽  
pp. S20-S21
Author(s):  
Vadim Sumbayev ◽  
Inna Yasinska ◽  
Bernhard Gibbs
Keyword(s):  
Hypoxia Inducible Factor ◽  
Allergic Inflammation ◽  
Innate Immune ◽  
Immune Defence ◽  
Hypoxia Inducible Factor 1 ◽  
Innate Immune Defence

scholarly journals A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps

2012 ◽  
Vol 446 (1) ◽  
pp. 159-163 ◽  
Author(s):  
Katja Branitzki-Heinemann ◽  
Cheryl Y. Okumura ◽  
Lena Völlger ◽  
Yuko Kawakami ◽  
Toshiaki Kawakami ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Mast Cell ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Regulator ◽  
Innate Immune ◽  
Immune Defence ◽  
Extracellular Traps ◽  
Innate Immune Defence ◽  
Critical Components ◽  
First Time

MCs (mast cells) are critical components of the host innate immune defence against bacterial pathogens, providing a variety of intra- and extra-cellular antimicrobial functions. In the present study we show, for the first time, that the transcriptional regulator HIF-1α (hypoxia-inducible factor-1α) mediates the extracellular antimicrobial activity of human and murine MCs by increasing the formation of MCETs (MC extracellular traps).

Innate immune defence in the human gastrointestinal tract

2005 ◽  
Vol 42 (8) ◽  
pp. 903-912 ◽  
Author(s):  
Rachel Dommett ◽  
Matthias Zilbauer ◽  
John T. George ◽  
Mona Bajaj-Elliott
Keyword(s):  
Gastrointestinal Tract ◽  
Innate Immune ◽  
Immune Defence ◽  
Human Gastrointestinal Tract ◽  
Innate Immune Defence

Trained immunity: A smart way to enhance innate immune defence

2015 ◽  
Vol 68 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Jos W.M. van der Meer ◽  
Leo A.B. Joosten ◽  
Niels Riksen ◽  
Mihai G. Netea
Keyword(s):  
Innate Immune ◽  
Immune Defence ◽  
Trained Immunity ◽  
Innate Immune Defence

A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptides

2014 ◽  
Vol 103 (10) ◽  
pp. 1000-1008 ◽  
Author(s):  
Ylva Kai-Larsen ◽  
Gudmundur H. Gudmundsson ◽  
Birgitta Agerberth
Keyword(s):  
Antimicrobial Peptides ◽  
Innate Immune ◽  
Immune Defence ◽  
Human Foetus ◽  
Innate Immune Defence

scholarly journals HIF-1, the Warburg Effect, and Macrophage/Microglia Polarization Potential Role in COVID-19 Pathogenesis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Elisabetta Ferraro ◽  
Maria Germanò ◽  
Rocco Mollace ◽  
Vincenzo Mollace ◽  
Natalia Malara
Keyword(s):  
Potential Role ◽  
Immune Reaction ◽  
Hypoxia Inducible Factor ◽  
Innate Immune ◽  
Metabolic Reprogramming ◽  
Clinical Knowledge ◽  
Respiratory Dysfunction ◽  
Hypoxia Inducible Factor 1 ◽  
Microglia Polarization ◽  
The Warburg Effect

Despite the international scientific community’s commitment to improve clinical knowledge about coronavirus disease 2019 (COVID-19), knowledge regarding molecular details remains limited. In this review, we discuss hypoxia’s potential role in the pathogenesis of the maladaptive immune reaction against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The state of infection, with serious respiratory dysfunction, causes tissues to become hypoxic due to a discrepancy between cellular O2 uptake and consumption similar to that seen within tumor tissue during the progression of numerous solid cancers. In this context, the heterogeneous clinical behavior and the multiorgan deterioration of COVID-19 are discussed as a function of the upregulated expression of the hypoxia-inducible factor-1 (HIF-1) and of the metabolic reprogramming associated with HIF-1 and with a proinflammatory innate immune response activation, independent of the increase in the viral load of SARS-CoV-2. Possible pharmacological strategies targeting O2 aimed to improve prognosis are suggested.

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