Abstract
Purpose: High-flow nasal cannula oxygen therapy (HFNC) has been increasingly reported over the past decades. Therefore, this study aimed to analyze the evolution of HFNC research and qualitatively and quantitatively evaluate publications. Methods: Publications between 2000 and 2019 were retrieved from the Web of Science Core Collection on August 17, 2020, according to a search strategy. Different kinds of software, CiteSpace and VOSviewer, and an online bibliometric analysis platform were used to identify top authors, journals, institutions, countries, keywords, co-cited articles, and trends. Results: Finally, 835 publications were identified, and the annual number of publications showed an increasing trend. Of these, 273 journals published articles related to HFNC. The United States and the University of Melbourne were the leading country and institution for publications, respectively. Co-cited reference analysis revealed top landmark articles. High-flow nasal cannula, bronchiolitis, hypercapnia, newborn, and immunosuppression are some of the high-frequency keywords in the co-occurrence cluster and co-cited reference cluster analyses, indicating that the clinical application of oxygen therapy remains a hot spot. Burst detection analysis of top keywords showed that randomized controlled trial, viral bronchiolitis, and immunocompromised patient were the new research foci.Conclusions: Bronchopulmonary dysplasia, infant, premature infant, respiratory distress syndrome, critical care patient, preoxygenation, extubation failure, and acute lung injury are the research foci of HFNC over the past 20 years and have emerged as a basis for transformation from infancy to adulthood and from a single disease to diverse diseases.
Clinical Progress Note: High Flow Nasal Cannula Therapy
for Bronchiolitis Outside the ICU in Infants
