Research Trends on High-Flow Nasal Cannula Oxygen Therapy: A Bibliometric Analysis from 2000 to 2019

Abstract Purpose: High-flow nasal cannula oxygen therapy (HFNC) has been increasingly reported over the past decades. Therefore, this study aimed to analyze the evolution of HFNC research and qualitatively and quantitatively evaluate publications. Methods: Publications between 2000 and 2019 were retrieved from the Web of Science Core Collection on August 17, 2020, according to a search strategy. Different kinds of software, CiteSpace and VOSviewer, and an online bibliometric analysis platform were used to identify top authors, journals, institutions, countries, keywords, co-cited articles, and trends. Results: Finally, 835 publications were identified, and the annual number of publications showed an increasing trend. Of these, 273 journals published articles related to HFNC. The United States and the University of Melbourne were the leading country and institution for publications, respectively. Co-cited reference analysis revealed top landmark articles. High-flow nasal cannula, bronchiolitis, hypercapnia, newborn, and immunosuppression are some of the high-frequency keywords in the co-occurrence cluster and co-cited reference cluster analyses, indicating that the clinical application of oxygen therapy remains a hot spot. Burst detection analysis of top keywords showed that randomized controlled trial, viral bronchiolitis, and immunocompromised patient were the new research foci.Conclusions: Bronchopulmonary dysplasia, infant, premature infant, respiratory distress syndrome, critical care patient, preoxygenation, extubation failure, and acute lung injury are the research foci of HFNC over the past 20 years and have emerged as a basis for transformation from infancy to adulthood and from a single disease to diverse diseases.

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S68 The Hi-flo Study: A Prospective Open Randomised Controlled Trial Of High Flow Nasal Cannula Oxygen Therapy Against Standard Care In Bronchiolitis

Thorax ◽

10.1136/thoraxjnl-2014-206260.74 ◽

2014 ◽

Vol 69 (Suppl 2) ◽

pp. A38-A38

Author(s):

C. Hathorn ◽

G. Ernst ◽

S. Hasan ◽

D. Wong ◽

M. Seear

Keyword(s):

Randomised Controlled Trial ◽

Standard Care ◽

Oxygen Therapy ◽

Controlled Trial ◽

High Flow ◽

Nasal Cannula ◽

High Flow Nasal Cannula ◽

Randomised Controlled

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Comparative evaluation of high-flow nasal cannula and conventional oxygen therapy in paediatric cardiac surgical patients: a randomized controlled trial

Interactive Cardiovascular and Thoracic Surgery ◽

10.1093/icvts/ivu171 ◽

2014 ◽

Vol 19 (3) ◽

pp. 456-461 ◽

Cited By ~ 30

Author(s):

Giuseppina Testa ◽

Francesca Iodice ◽

Zaccaria Ricci ◽

Vincenzo Vitale ◽

Francesca De Razza ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Comparative Evaluation ◽

Oxygen Therapy ◽

Controlled Trial ◽

High Flow ◽

Nasal Cannula ◽

Surgical Patients ◽

High Flow Nasal Cannula ◽

Randomized Controlled

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Benefits of High-Flow Nasal Cannula Therapy for Acute Pulmonary Edema in Patients with Heart Failure in the Emergency Department: A Prospective Multi-Center Randomized Controlled Trial

Journal of Clinical Medicine ◽

10.3390/jcm9061937 ◽

2020 ◽

Vol 9 (6) ◽

pp. 1937 ◽

Cited By ~ 1

Author(s):

Dong Ryul Ko ◽

Jinho Beom ◽

Hye Sun Lee ◽

Je Sung You ◽

Hyun Soo Chung ◽

...

Keyword(s):

Heart Failure ◽

Emergency Department ◽

Pulmonary Edema ◽

Oxygen Therapy ◽

Controlled Trial ◽

High Flow ◽

Nasal Cannula ◽

High Flow Nasal Cannula ◽

Arterial Blood Gas ◽

Arterial Blood

Heart failure patients with pulmonary edema presenting to the emergency department (ED) require an effective approach to deliver sufficient oxygen and reduce the rate of intubation and mechanical ventilation in the ED; conventional oxygen therapy has proven ineffective in delivering enough oxygen to the tissues. We aimed to identify whether high-flow nasal cannula (HFNC) therapy over time improved the respiratory rate (RR), lactate clearance, and certain arterial blood gas (ABG) parameters, in comparison with conventional oxygen therapy, in patients with cardiogenic pulmonary edema. This prospective, multi-institutional, and interventional study (clinical trial, reference KCT0004578) conducted between 2016 and 2019 included adult patients diagnosed with heart failure within the previous year and pulmonary edema confirmed at admission. Patients were randomly assigned to the conventional or HFNC group and treated with the goal of maintaining oxygen saturation (SpO2) ≥ 93. We obtained RR, SpO2, lactate levels, and ABG parameters at baseline and 30 and 60 min after randomization. All parameters showed greater improvement with HFNC therapy than with conventional therapy. Significant changes in ABG parameters were achieved within 30 min. HFNC therapy could therefore be considered as initial oxygen therapy. Physicians may consider advanced ventilation if there is no significant improvement in ABG parameters within 30 min of HFNC therapy.

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Modified high-flow nasal cannula oxygen therapy versus conventional oxygen therapy in patients undergoing bronchoscopy: a randomized clinical trial

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01744-8 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Rui Wang ◽

Hai-Chao Li ◽

Xu-Yan Li ◽

Xiao Tang ◽

Hui-Wen Chu ◽

...

Keyword(s):

Clinical Trial ◽

Oxygen Therapy ◽

Therapy Group ◽

Controlled Trial ◽

Arterial Oxygen Saturation ◽

High Flow ◽

Nasal Cannula ◽

Arterial Oxygen ◽

High Flow Nasal Cannula ◽

Single Moment

Abstract Background Hypoxemia frequently occurs during bronchoscopy. High-flow nasal cannula (HFNC) oxygen therapy may be a feasible alternative to prevent the deterioration of gas exchange during bronchoscopy. With the convenience of clinical use in mind, we modified an HFNC using a single cannula. This clinical trial was designed to test the hypothesis that a modified HFNC would decrease the proportion of patients with a single moment of peripheral arterial oxygen saturation (SpO2) < 90% during bronchoscopy. Methods In this single-center, prospective randomized controlled trial, hospitalized patients in the respiratory department in need of diagnostic bronchoscopy were randomly assigned to a modified HFNC oxygen therapy group or a conventional oxygen therapy (COT) group. The primary outcome was the proportion of patients with a single moment of SpO2 < 90% during bronchoscopy. Results Eight hundred and twelve patients were randomized to the modified HFNC (n = 406) or COT (n = 406) group. Twenty-four patients were unable to cooperate or comply with bronchoscopy. Thus, 788 patients were included in the analysis. The proportion of patients with a single moment of SpO2 < 90% during bronchoscopy in the modified HFNC group was significantly lower than that in the COT group (12.5% vs. 28.8%, p < 0.001). There were no significant differences in the fraction of inspired oxygen between the two groups. The lowest SpO2 during bronchoscopy and 5 min after bronchoscopy in the modified HFNC group was significantly higher than that in the COT group. Multivariate analysis showed that a baseline forced vital capacity (FVC) < 2.7 L (OR, 0.276; 95% CI, 0.083–0.919, p = 0.036) and a volume of fluid instilled > 60 ml (OR, 1.034; 95% CI, 1.002–1.067, p = 0.036) were independent risk factors for hypoxemia during bronchoscopy in the modified HFNC group. Conclusions A modified HFNC could decrease the proportion of patients with a single moment of SpO2 < 90% during bronchoscopy. A lower baseline FVC and large-volume bronchoalveolar lavage may predict desaturation during bronchoscopy when using a modified HFNC. Trial registration ClinicalTrials. Gov: NCT02606188. Registered 17 November 2015.

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