Vagal Tone and Proinflammatory Cytokines Predict Feeding Intolerance and Necrotizing Enterocolitis Risk

2021 ◽  
Vol 21 (6) ◽  
pp. 452-461
Author(s):  
Alissa L. Meister ◽  
Fumiyuki C. Gardner ◽  
Kirsteen N. Browning ◽  
R. Alberto Travagli ◽  
Charles Palmer ◽  
...  
Keyword(s):  
Necrotizing Enterocolitis ◽  
Proinflammatory Cytokines ◽  
Vagal Tone ◽  
Feeding Intolerance

Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis

2007 ◽  
Vol 42 (3) ◽  
pp. 454-461 ◽  
Author(s):  
Renu Sharma ◽  
Joseph J. Tepas ◽  
Mark L. Hudak ◽  
Daniel L. Mollitt ◽  
Peter S. Wludyka ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Necrotizing Enterocolitis ◽  
Proinflammatory Cytokines ◽  
Multiple Organ ◽  
Gut Barrier

scholarly journals Bacterial contamination of nasogastric feeding tube and development of neonatal sepsis in premature newborns: a prospective observational research at a tertiary care center in Gujarat, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1462
Author(s):  
Rekha Thaddanee ◽  
Shamim Morbiwala ◽  
Hasmukh Chauhan ◽  
Jigar Gusani ◽  
Parima Dalal
Keyword(s):  
Necrotizing Enterocolitis ◽  
Neonatal Sepsis ◽  
Microbial Growth ◽  
Tertiary Care ◽  
Feeding Tube ◽  
Feeding Intolerance ◽  
Nasogastric Feeding ◽  
Premature Newborns ◽  
Nasogastric Feeding Tube ◽  
Group I

Background: The objective of the present study is to observe the effect of frequency of changing nasogastric feeding tube (NG-FT) on microbial growth in relation to development of neonatal sepsis in premature newborns. The study is prospective observational study in its nature. Neonatal intensive care unit (NICU) of a tertiary care teaching hospital of western Gujarat, India, from December 2016 to November 2017.Methods: Eighty-five preterm newborns admitted to NICU for feeding support were randomly divided into three groups depending on frequency of changing nasogastric feeding tubes (Group I, II and III with NG-FT changed every 12, 24 and 48 hourly respectively). In Groups I, II and III, the first NG-FT cultures were sent at the end of 12, 24, 48 hours of NG-FT insertion respectively. The second and third NG-FT cultures were sent after 7 and 14 days respectively. Microbial growth pattern was observed and correlated with development of necrotizing enterocolitis (NEC), neonatal sepsis and mortality.Results: Microbial growth on first NG-FT culture significantly increased when frequency of changing nasogastric feeding tube was reduced from every 12 to 24 or 48 hours {p = 0.0432 (Group I vs II) and 0.0001 (Group I vs III)}. Microbial growth increased on second (24.1%, 87% and 85% in groups I, II and III respectively) and third NG-FT culture (44% in group I and 100% in groups II and III); this was significantly high in group II and III as compared to group I (p = 0.0001). Common organisms isolated were Klebsiella pneumonia (63.28%), Pseudomonas aeruginosa (32%) and Escherichia coli (21%). No significant difference was noted in incidences of feeding intolerance, necrotizing enterocolitis (NEC), neonatal sepsis and mortality among the three groups.Conclusions: Organism growth in nasogastric feeding tube culture increases significantly when frequency of changing NG-FT is beyond 12 hours. However, there is no increase in episodes of feeding intolerance, necrotizing enterocolitis (NEC), neonatal sepsis and mortality.

scholarly journals Circulating Interleukin-8 in Neonatal Feeding Intolerance and Necrotizing Enterocolitis

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 114A-114A
Author(s):  
Aideen Moore ◽  
Talat Ahmed ◽  
Alixe Howlett ◽  
Arne Ohlsson ◽  
Patrick St Louis
Keyword(s):  
Necrotizing Enterocolitis ◽  
Interleukin 8 ◽  
Feeding Intolerance

scholarly journals Dysbiosis and Prematurity: Is There a Role for Probiotics?

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1273 ◽  
Author(s):  
Maria Elisabetta Baldassarre ◽  
Antonio Di Mauro ◽  
Manuela Capozza ◽  
Valentina Rizzo ◽  
Federico Schettini ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Preterm Birth ◽  
Preterm Infant ◽  
Necrotizing Enterocolitis ◽  
Feeding Intolerance ◽  
Probiotic Supplementation ◽  
Meta Analyses

Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

scholarly journals Is preterm donor milk better than preterm formula for very-low-birth-weight infants?

2021 ◽  
Author(s):  
Lingyu Fang ◽  
Meili Zhang ◽  
Lianqiang Wu ◽  
Ruiquan Wang ◽  
Bangbang Lin ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Very Low Birth Weight ◽  
Feeding Intolerance ◽  
Low Birth Weight Infants ◽  
Severe Morbidity ◽  
Preterm Formula ◽  
Feeding Tolerance

Background: Preterm human milk has advantages over preterm formula (PF), but it may compromise some functions after pasteurization. Objective: To explore the effects of preterm donor milk (DM) on growth, feeding tolerance, and severe morbidity in very-low-birth-weight infants. Method: This was a single-center, prospective cohort study that included 304 preterm infants weighing <1,500 g or of gestational age <32 weeks. If the mother’s own milk was insufficient, the parents decided to use PF (n = 155) or DM (n = 149). The two groups were uniformly managed according to the standard NICU protocol. Growth parameters, feeding tolerance, and severe morbidity such as necrotizing enterocolitis, were compared between the two groups. Results: The daily weight gain and weekly head growth in the DM group were not different from those in the PF group (P > 0.05). Feeding intolerance in the DM group was significantly lower than that in PF group (P < 0.05), and parenteral nutrition time and hospitalization time were also shorter than that in the PF group (P < 0.05). Moreover, the incidence of necrotizing enterocolitis and sepsis was also significantly lower in the DM group (P < 0.05). Conclusion: The study indicated that preterm DM does not affect the growth of very-low-birth-weight infants. Further, it significantly reduces feeding intolerance, helps achieve full enteral feeding early, and has protective effects against necrotizing enterocolitis and sepsis. Thus, compared with formula, preterm DM can lower the rate of infection in preterm infants and is worthy of promotion.

scholarly journals Diminished vagal tone is a predictive biomarker of necrotizing enterocolitis-risk in preterm infants

2014 ◽  
Vol 26 (6) ◽  
pp. 832-840 ◽  
Author(s):  
K. K. Doheny ◽  
C. Palmer ◽  
K. N. Browning ◽  
P. Jairath ◽  
D. Liao ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Vagal Tone ◽  
Predictive Biomarker

scholarly journals Gastric Residuals, Feeding Intolerance, and Necrotizing Enterocolitis in Preterm Infants

2015 ◽  
Vol 56 (2) ◽  
pp. 136-137
Author(s):  
Bai-Horng Su ◽  
Hsiang-Yu Lin ◽  
Fu-Kuei Huang ◽  
Ming-Luen Tsai
Keyword(s):  
Preterm Infants ◽  
Necrotizing Enterocolitis ◽  
Feeding Intolerance
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