A SRSF1 self-binding mechanism restrains Mir505-3p from inhibiting proliferation of neural tumor cell lines

✓ Although the presence of lymphoreticular cells within tumors has been recognized for over 100 years, it is only within the last decade that the concept has arisen that standard histological examination techniques may lead to an underestimation of the true extent of tumor infiltration by lymphoreticular cells, and particularly by macrophages. The macrophage content of certain systemic tumors has been correlated with their immunogenicity and growth characteristics. Since the central nervous system is to some extent an “immunologically privileged site” and contains within it specialized reticuloendothelial cells called microglia, the authors determined the macrophage content of three rodent brain-tumor cell lines, and attempted to correlate this macrophage content with their immunogenicity and growth characteristics. Their findings indicate a direct correlation between the immunogenicity and macrophage content of these three neural tumor cell lines.

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Migratory potential of transplantable neural tumor cell lines

Acta Neuropathologica ◽

10.1007/s004010051036 ◽

1999 ◽

Vol 97 (6) ◽

pp. 607-612 ◽

Cited By ~ 1

Author(s):

T. A. Bayer ◽

Michael Thier ◽

Elke Roeb ◽

Bettina Breuer ◽

Sascha Weggen ◽

...

Keyword(s):

Tumor Cell ◽

Cell Lines ◽

Tumor Cell Lines ◽

Neural Tumor

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Expression of HIF-1a and VEGF in human pituitary tumors and rodent pituitary tumor cell lines under hypoxia-mimicking condition

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0028-1096352 ◽

2008 ◽

Vol 116 (09) ◽

Author(s):

B Shan ◽

C Onofri ◽

M Theodoropoulou ◽

E Arzt ◽

GK Stalla ◽

...

Keyword(s):

Tumor Cell ◽

Cell Lines ◽

Pituitary Tumor ◽

Pituitary Tumors ◽

Tumor Cell Lines ◽

Human Pituitary ◽

Pituitary Tumor Cell

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Interaction of Human Tumor Cells with Human Platelets and the Coagulation System

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665296 ◽

1983 ◽

Vol 50 (03) ◽

pp. 726-730 ◽

Cited By ~ 11

Author(s):

Hamid Al-Mondhiry ◽

Virginia McGarvey ◽

Kim Leitzel

Keyword(s):

Tumor Cell ◽

Tumor Cells ◽

Cell Lines ◽

Human Tumor ◽

Human Platelets ◽

Factor Vii ◽

Coagulation System ◽

Breast Adenocarcinoma ◽

Activate Factor ◽

Tumor Cell Lines

SummaryThis paper reports studies on the interaction between human platelets, the plasma coagulation system, and two human tumor cell lines grown in tissue culture: Melanoma and breast adenocarcinoma. The interaction was monitored through the use of 125I- labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Each tumor cell line activates both the platelets and the coagulation system simultaneously resulting in the generation of thrombin or thrombin-like activity. The melanoma cells activate the coagulation system through “the extrinsic pathway” with a tissue factor-like effect on factor VII, but the breast tumor seems to activate factor X directly. Both tumor cell lines activate platelets to “make available” a platelet- derived procoagulant material necessary for the conversion of prothrombin to thrombin. The tumor-derived procoagulant activity and the platelet aggregating potential of cells do not seem to be inter-related, and they are not specific to malignant cells.

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