Improved outcomes of cardiopulmonary resuscitation in rats with myocardial infarction treated with allogenic bone marrow mesenchymal stem cells*

2009 ◽  
Vol 37 (3) ◽  
pp. 833-839 ◽  
Author(s):  
Tong Wang ◽  
Wanchun Tang ◽  
Shijie Sun ◽  
Giuseppe Ristagno ◽  
Tingyan Xu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cardiopulmonary Resuscitation ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow ◽  
Improved Outcomes ◽  
Marrow Mesenchymal Stem Cells

Repair of Ear Cartilage Defects with Allogenic Bone Marrow Mesenchymal Stem Cells in Rabbits

2014 ◽  
Vol 70 (2) ◽  
pp. 1137-1143 ◽  
Author(s):  
You Cheng ◽  
Peng Cheng ◽  
Fei Xue ◽  
Kun-min Wu ◽  
Man-jie Jiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cartilage Defects ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow ◽  
Marrow Mesenchymal Stem Cells ◽  
Ear Cartilage

scholarly journals Bone Marrow Mesenchymal Stem Cells (BM-MSCs) Improve Heart Function in Swine Myocardial Infarction Model through Paracrine Effects

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Min Cai ◽  
Rui Shen ◽  
Lei Song ◽  
Minjie Lu ◽  
Jianguang Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Signal Transduction ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Glucose Metabolism ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Pet Ct ◽  
Marrow Mesenchymal Stem Cells

Abstract Stem cells are promising for the treatment of myocardial infarction (MI) and large animal models should be used to better understand the full spectrum of stem cell actions and preclinical evidences. In this study, bone marrow mesenchymal stem cells (BM-MSCs) were transplanted into swine heart ischemia model. To detect glucose metabolism in global left ventricular myocardium and regional myocardium, combined with assessment of cardiac function, positron emission tomography-computer tomography (PET-CT) and magnetic resonance imaging (MRI) were performed. To study the changes of glucose transporters and glucose metabolism-related enzymes and the signal transduction pathway, RT-PCR, Western-blot, and immunohistochemistry were carried out. Myocardium metabolic evaluation by PET-CT showed that mean signal intensity (MSI) increased in these segments at week 4 compared with that at week 1 after BM-MSCs transplantation. Moreover, MRI demonstrated significant function enhancement in BM-MSCs group. The gene expressions of glucose transporters (GLUT1, GLUT4), glucose metabolism-related enzymes phosphofructokinase (PFK), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)) and 70-kDa ribosomal protein S6 kinase (p70s6k) in BM-MSCs injected areas were up-regulated at week 4 after BM-MSCs transplantation and this was confirmed by Western-blot and immunohistochemistry. In conclusions, BM-MSCs transplantation could improve cardiac function in swine MI model by activation of mTOR signal transduction pathway.

scholarly journals Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke

2013 ◽  
Vol 4 (1) ◽  
pp. 11 ◽  
Author(s):  
María Gutiérrez-Fernández ◽  
Berta Rodríguez-Frutos ◽  
Jaime Ramos-Cejudo ◽  
M Teresa Vallejo-Cremades ◽  
Blanca Fuentes ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Ischemic Stroke ◽  
Functional Recovery ◽  
Intravenous Administration ◽  
Brain Repair ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow

Comparison of autogenic and allogenic bone marrow derived mesenchymal stem cells for repair of segmental bone defects in rabbits

2013 ◽  
Vol 94 (3) ◽  
pp. 743-752 ◽  
Author(s):  
Rahul Kumar Udehiya ◽  
Amarpal ◽  
H.P. Aithal ◽  
P. Kinjavdekar ◽  
A.M. Pawde ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Bone Defects ◽  
Allogenic Bone ◽  
Allogenic Bone Marrow ◽  
Segmental Bone ◽  
Segmental Bone Defects
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