Differential Expression of Bcl-2 Family Proteins Determines the Sensitivity of Human Follicular Lymphoma Cells to Dexamethasone-mediated and Anti-BCR-mediated Apoptosis

2016 ◽  
Vol 39 (1) ◽  
pp. 8-14 ◽  
Author(s):  
Jemal Adem ◽  
Antti Ropponen ◽  
Jonna Eeva ◽  
Mine Eray ◽  
Ulla Nuutinen ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Differential Expression ◽  
Lymphoma Cells

Flow cytometry using the monoclonal antibody CD10-Pe/Cy5 is a useful tool to identify follicular lymphoma cells

2001 ◽  
Vol 66 (2) ◽  
pp. 100-106 ◽  
Author(s):  
M. Bellido ◽  
E. Rubiol ◽  
J. Ubeda ◽  
O. Lopez ◽  
C. Estivill ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Flow Cytometry ◽  
Follicular Lymphoma ◽  
Lymphoma Cells

scholarly journals Genome-Wide DNA Methylation Maps in Follicular Lymphoma Cells Determined by Methylation-Enriched Bisulfite Sequencing

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e13020 ◽  
Author(s):  
Jeong-Hyeon Choi ◽  
Yajun Li ◽  
Juyuan Guo ◽  
Lirong Pei ◽  
Tibor A. Rauch ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Follicular Lymphoma ◽  
Bisulfite Sequencing ◽  
Lymphoma Cells ◽  
Genome Wide

Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma

Blood ◽  
2004 ◽  
Vol 103 (2) ◽  
pp. 695-697 ◽  
Author(s):  
Wei-Li Zhao ◽  
Marjan Ertault Daneshpouy ◽  
Nicolas Mounier ◽  
Josette Brière ◽  
Christophe Leboeuf ◽  
...  
Keyword(s):  
Gene Expression ◽  
Follicular Lymphoma ◽  
Apoptotic Cell ◽  
International Prognostic Index ◽  
Prognostic Significance ◽  
Prognostic Index ◽  
Pcr Analysis ◽  
Survival Times ◽  
Lymphoma Cells ◽  
Cell Counts

Abstract bcl-xL, a member of the Bcl-2 family, exerts an antiapoptotic effect on lymphocytes. To assess its clinical significance in patients with follicular lymphoma, realtime quantitative reverse transcription–polymerase chain reaction (RT-PCR) analysis of bcl-xL gene expression was investigated in whole lymph node sections and laser-microdissected lymphoma cells of 27 patients. Compared with 10 patients with reactive follicular hyperplasia, the bcl-xL gene was overexpressed in patients with follicular lymphoma at a higher level in microdissected lymphoma cells. The bcl-xL gene level correlated with the number of apoptotic lymphoma cells labeled by terminal deoxytransferase-catalyzed DNA nick-end labeling (TUNEL) assays (r = -0.7736). Clinically, a high bcl-xL level was significantly associated with multiple sites of extranodal involvement (P = .0020), elevated lactate dehydrogenase level (P = .0478), and an International Prognostic Index indicating high risk (P = .0235). Moreover, bcl-xL gene overexpression was linked to short overall survival times (P = .0129). The value of bcl-xL gene expression as a prognostic marker in follicular lymphoma should thus be considered.

T-cell derived cytokines co-stimulate proliferation of CD40-activated germinal centre as well as follicular lymphoma cells

1997 ◽  
Vol 15 (4) ◽  
pp. 197-207 ◽  
Author(s):  
Doris Schmitter ◽  
Michael Koss ◽  
Eva Niederer ◽  
Rolf Arno Stahel ◽  
Gabriella Pichert
Keyword(s):  
T Cell ◽  
Follicular Lymphoma ◽  
Germinal Centre ◽  
Lymphoma Cells

scholarly journals Resistance of Follicular Lymphoma Cells to Chemotherapy Is More Than Just Bcl-2

2003 ◽  
Vol 2 (5) ◽  
pp. 541-543 ◽  
Author(s):  
Peter Hersey ◽  
Xu Dong Zhang
Keyword(s):  
Follicular Lymphoma ◽  
Lymphoma Cells

Rituximab-induced early and late signaling have opposite effects on dexamethasone-induced apoptosis in human follicular lymphoma cells

2015 ◽  
Vol 56 (8) ◽  
pp. 2448-2457 ◽  
Author(s):  
Jemal Adem ◽  
Antti Ropponen ◽  
Jonna Eeva ◽  
Mine Eray ◽  
Jukka Pelkonen ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Lymphoma Cells ◽  
Induced Apoptosis

Weekly x 4 Induction Therapy with the Anti-CD20 Antibody Rituximab: Effect on Circulating t(14;18)+ Follicular Lymphoma Cells

2001 ◽  
Vol 1 (4) ◽  
pp. 293-297 ◽  
Author(s):  
Gabriella Pichert ◽  
Shu-Fang Hsu Schmitz ◽  
Urs Hess ◽  
Thomas Cerny ◽  
Sergio Bruno Cogliatti ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Induction Therapy ◽  
Lymphoma Cells ◽  
Cd20 Antibody ◽  
Anti Cd20

Apoptotic Induction in Transformed Follicular Lymphoma Cells by Bcl-2 Downregulation

1998 ◽  
Vol 30 (3-4) ◽  
pp. 367-380 ◽  
Author(s):  
Mar Tormo ◽  
Ana Maria Tari ◽  
Timothy J. McDonnell ◽  
Fernando Cabanillas ◽  
Javier Garcia-Conde ◽  
...  
Keyword(s):  
Follicular Lymphoma ◽  
Lymphoma Cells ◽  
Transformed Follicular Lymphoma ◽  
Apoptotic Induction
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