Adenovirus-specific T-cell Subsets in Human Peripheral Blood and After IFN-γ Immunomagnetic Selection

2016 ◽  
Vol 39 (1) ◽  
pp. 27-35 ◽  
Author(s):  
Chongsheng Qian ◽  
Yingying Wang ◽  
Huili Cai ◽  
Caroline Laroye ◽  
Marcelo De Carvalho Bittencourt ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Ifn Γ ◽  
Immunomagnetic Selection

Assessment of a positive selection technique using an avidin column to isolate human peripheral blood T cell subsets

1994 ◽  
Vol 175 (2) ◽  
pp. 247-257 ◽  
Author(s):  
Laurie S. Davis ◽  
Melissa J. McIlraith ◽  
Trang Paecheo ◽  
Brent Becker ◽  
Leah M. Adix ◽  
...  
Keyword(s):  
T Cell ◽  
Positive Selection ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Selection Technique

scholarly journals Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood

2016 ◽  
Vol 113 (41) ◽  
pp. E6192-E6198 ◽  
Author(s):  
Laura F. Su ◽  
Daniel del Alcazar ◽  
Erietta Stelekati ◽  
E. John Wherry ◽  
Mark M. Davis
Keyword(s):  
T Cells ◽  
T Cell ◽  
Peripheral Blood ◽  
Ex Vivo ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Major Influence ◽  
Cell Phenotype ◽  
Antigen Specificity ◽  
Cell Repertoire

The T-cell receptor (TCR) is required for maturation and function of regulatory T cells (Tregs), but the ligand specificities of Tregs outside the context of transgenic TCRs are largely unknown. Using peptide–MHC tetramers, we isolated rare specific Foxp3+ cells directly ex vivo from adult peripheral blood and defined their frequency and phenotype. We find that a proportion of circulating Tregs recognize foreign antigens and the frequency of these cells are similar to that of self-reactive Tregs in the absence of cognate infection. In contrast, the frequencies of Tregs that recognize some common microbial antigens are significantly reduced in the blood of most adults. Exposure to peripheral antigens likely has a major influence on the balance between Tregs and conventional T-cell subsets because a larger proportion of flu-specific T cells has a regulatory cell phenotype in the cord blood. Consistent with this finding, we show that lymphocytic choriomeningitis virus infection can directly modulate the ratio of virus-specific effectors and Tregs in mice. The resulting change in the balance within an antigen-specific T-cell population further correlates with the magnitude of effector response and the chronicity of infection. Taken together, our data highlight the importance of antigen specificity in the functional dynamics of the T-cell repertoire. Each specific population of CD4+ T cells in human peripheral blood contains a subset of Tregs at birth, but the balance between regulatory and effector subsets changes in response to peripheral antigen exposure and this could impact the robustness of antipathogen immunity.

Different IL‐5 and IFN‐γ Production from Peripheral Blood T‐Cell Subsets in Atopic and Nonatopic Asthmatic Children

2004 ◽  
Vol 41 (8) ◽  
pp. 869-876 ◽  
Author(s):  
Ja‐Hyung Kim ◽  
Bong‐Seong Kim ◽  
So‐Yeon Lee ◽  
Ji‐Hye Seo ◽  
Jeong‐Yeon Shim ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
T Cell Subsets ◽  
Asthmatic Children ◽  
Ifn Γ

Age-dependent changes in human peripheral blood B cells and T-cell subsets: Correlation with mitogen responsiveness

1980 ◽  
Vol 15 (2) ◽  
pp. 162-174 ◽  
Author(s):  
Melody A. Cobleigh ◽  
Donald P. Braun ◽  
Jules E. Harris
Keyword(s):  
T Cell ◽  
B Cells ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Age Dependent ◽  
Mitogen Responsiveness

Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells

2018 ◽  
Vol 373 (2) ◽  
pp. 459-476 ◽  
Author(s):  
Paula Laranjeira ◽  
Marta Duque ◽  
Martin Vojtek ◽  
Maria J. Inácio ◽  
Isabel Silva ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Amniotic Membrane ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Myeloid Dendritic Cells ◽  
Monocyte Subpopulations ◽  
Membrane Extract

Differential age-change in the numbers of CD4+CD45RA+ DC4+CD29+ T cell subsets in human peripheral blood

1992 ◽  
Vol 63 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Masanori Utsuyama ◽  
Katsuiku Hirokawa ◽  
Chieri Kurashima ◽  
Makiko Fukayama ◽  
Takashi Inamatsu ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
T Cell Subsets ◽  
Age Change
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