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Author(s):  
Mohanish Bawane

Abstract: MERN stack is one of the well known web stack that has acquired significance over other stack. This is a direct result of its UI delivering and execution, Cost-Adequacy, Open Source and is not difficult to switch among customer and server. Its essential target is to improve the general exhibition of the application. This stack, as well as utilizing superior execution and tweaked advances, considers web applications and programming to be grown rapidly. MERN stack is an assortment of strong and amazing innovations used to foster adaptable expert web applications, containing front-end, back-end, and data set parts. It is an innovation stack that is an easy to understand full-stack JavaScript structure for building dynamic sites and applications. This is the explanation it is the most favored stage by new businesses. This paper will depict MERN Stack involving 4 advancements to be specific: Mongo DB, Express, Respond and Node.js. Every one of these 4 incredible advancements gives a start to finish system for the designers to work in and every one of these advances have a major influence in the improvement of web applications. Index Terms: MERN STACK, Mongo DB, Express JS, React JS, Node JS platform


2022 ◽  
Author(s):  
Tang Li ◽  
Yanbin Yin

Background: Large scale metagenome assembly and binning to generate metagenome-assembled genomes (MAGs) has become possible in the past five years. As a result, millions of MAGs have been produced and increasingly included in pan-genomics workflow. However, pan-genome analyses of MAGs may suffer from the known issues with MAGs: fragmentation, incompleteness, and contamination, due to mis-assembly and mis-binning. Here, we conducted a critical assessment of including MAGs in pan-genome analysis, by comparing pan-genome analysis results of complete bacterial genomes and simulated MAGs. Results: We found that incompleteness led to more significant core gene loss than fragmentation. Contamination had little effect on core genome size but had major influence on accessory genomes. The core gene loss remained when using different pan-genome analysis tools and when using a mixture of MAGs and complete genomes. Importantly, the core gene loss was partially alleviated by lowering the core gene threshold and using gene prediction algorithms that consider fragmented genes, but to a less degree when incompleteness was higher than 5%. The core gene loss also led to incorrect pan-genome functional predictions and inaccurate phylogenetic trees. Conclusions: We conclude that lowering core gene threshold and predicting genes in metagenome mode (as Anvio does with Prodigal) are necessary in pan-genome analysis of MAGs to alleviate the accuracy loss. Better quality control of MAGs and development of new pan-genome analysis tools specifically designed for MAGs are needed in future studies.


Materials ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 594
Author(s):  
Nicoleta Cobîrzan ◽  
Radu Muntean ◽  
Gyorgy Thalmaier ◽  
Raluca-Andreea Felseghi

Masonry units made of clay or Autoclaved Aerated Concrete (AAC) are widely used in constructions from Romania and other countries. Masonry units with superior mechanical and thermal characteristics can improve the energy efficiency of buildings, especially when they are used as the main solutions for building envelope construction. Their production in recent years has increased vertiginously to meet the increased demand. Manufactured with diversified geometries, different mechanical and/or thermal characteristics have a high volume in the mass of the building and a major influence in their carbon footprint. Starting from the current context regarding the target imposed by the long-term strategy of built environment decarbonization, the aim of the paper is to analyze the potential of reusing mining waste in the production of masonry units. Mining waste represents the highest share of waste generated at national level and may represent a valuable resource for the construction industry, facilitating the creation of new jobs and support for economic development. This review presents the interest in integrating mining wastes in masonry unit production and the technical characteristics of the masonry units in which they have been used as raw materials in different percentages. Critical assessment framework using SWOT analysis highlights the key sustainability aspects (technical, environmental, social, economic) providing a comprehensive and systematic analysis of the advantages and disadvantages regarding the integration of mining waste as secondary raw materials into masonry units production.


Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 339
Author(s):  
Janina Remy ◽  
Benedikt Linder ◽  
Ulrike Weirauch ◽  
Bryan W. Day ◽  
Brett W. Stringer ◽  
...  

Glioblastoma (GBM) is a devastating disease and the most common primary brain malignancy of adults with a median survival barely exceeding one year. Recent findings suggest that the antipsychotic drug pimozide triggers an autophagy-dependent, lysosomal type of cell death in GBM cells with possible implications for GBM therapy. One oncoprotein that is often overactivated in these tumors and associated with a particularly dismal prognosis is Signal Transducer and Activator of Transcription 3 (STAT3). Here, we used isogenic human and murine GBM knockout cell lines, advanced fluorescence microscopy, transcriptomic analysis and FACS-based assessment of cell viability to show that STAT3 has an underappreciated, context-dependent role in drug-induced cell death. Specifically, we demonstrate that depletion of STAT3 significantly enhances cell survival after treatment with Pimozide, suggesting that STAT3 confers a particular vulnerability to GBM. Furthermore, we show that active STAT3 has no major influence on the early steps of the autophagy pathway, but exacerbates drug-induced lysosomal membrane permeabilization (LMP) and release of cathepsins into the cytosol. Collectively, our findings support the concept of exploiting the pro-death functions of autophagy and LMP for GBM therapy and to further determine whether STAT3 can be employed as a treatment predictor for highly apoptosis-resistant, but autophagy-proficient cancers.


2022 ◽  
pp. 1-13
Author(s):  
Stephen Polgar ◽  
Melissa Buultjens ◽  
Tissa Wijeratne ◽  
David I. Finkelstein ◽  
Sheeza Mohamed ◽  
...  

In the field of stem cell technologies, exciting advances are taking place leading to translational research to develop cell-based therapies which may replace dopamine releasing neurons lost in patients with Parkinson’s disease (PD). A major influence on trial design has been the assumption that the use of sham operated comparator groups is required in the implementation of randomised double-blind trials to evaluate the placebo response and effects associated with the surgical implantation of cells. The aim of the present review is to identify the improvements in motor functioning and striatal dopamine release in patients with PD who have undergone sham surgery. Of the nine published trials, there was at the designated endpoints, a pooled average improvement of 4.3 units, with 95% confidence interval of 3.1 to 5.6 on the motor subscale of the Unified Parkinson’s Disease Scale in the ‘OFF’ state. This effect size indicates a moderate degree of improvement in the motor functioning of the patients in the sham surgical arms of the trials. Four of the nine trials reported the results of 18 F-fluorodopa PET scans, indicating no improvements of dopaminergic nigrostriatal neurones following sham surgery. Therefore, while the initial randomised trials relying on the use of sham operated controls were justified on methodological grounds, we suggest that the analysis of the evidence generated by the completed and published trials indicates that placebo controlled trials are not necessary to advance and evaluate the safety and efficacy of emerging regenerative therapies for PD.


2022 ◽  
Author(s):  
Freylan Mena ◽  
Seiling Vargas ◽  
Meyer Guevara-Mora ◽  
J. Mauro Vargas-Hernández ◽  
Clemens Ruepert

Abstract The estuarine ecosystem of Laguna Madre de Dios (LMD), in the Caribbean coast of Costa Rica, is exposed to contamination with pesticide residues coming from the upstream agricultural areas. Biomarkers can provide a better indication of the fitness of biota in real mixture exposure scenarios than traditional lethal dose toxicity measurements. Here, we measured biomarkers of biotransformation, oxidative stress and neurotoxicity on Astyanax aeneus, an abundant fish species in LMD. Glutathione S-transferase activity (GST), catalase activity (CAT), lipid peroxidation (LPO), and cholinesterase activity (ChE) were measured in fish collected during seven sampling campaigns, carried out between 2016 and 2018. Pesticide residues were analysed in surface water samples collected every time fish were sampled. Residues of 25 pesticides, including fungicides, insecticides and herbicides, were detected. The biomarkers measured in A. aeneus varied along the sampling moments, however, biotransformation and oxidative stress signals showed coupled responses throughout the assessment. Furthermore, significant correlations were established between three biomarkers (GST, LPO and CAT) and individual pesticides, as well as between GST and LPO with groups of pesticides with shared biocide action. Among pesticides, insecticide residues had a major influence on the responses observed in fish. This work shows that the frequent exposure to environmentally relevant concentrations of pesticides can be related to physiological responses in fish that affect their health. This early warning information should be considered to improve the protection of estuarine ecosystems in the tropics.


2022 ◽  
Vol 12 (2) ◽  
pp. 566
Author(s):  
Rihab Brahmi ◽  
Imen Belhadj ◽  
Moncef Hammadi ◽  
Nizar Aifaoui ◽  
Jean-Yves Choley

A mechanical product is the result of collaboration between different domains. In this paper we focus on the collaborative work that brings together the system engineer and the designer in the realization process of a mechanical system. A design solution, conceived in the CAD environment, is considered valid if all the specification requirements, defined in the MBSE (Model Based System Engineering) domain, are met. Thus, the preliminary study of these requirements has a major influence on the choice and validation of the design solution. In this paper a methodology for handling the requirements has been detailed. These requirements are classified into two main categories. The first one deals with the product performance and the second addresses the process performance in order to generate the best assembly sequence. Depending on the response of the designed solution to these requirements, it becomes easy to decide not only whether the design solution can be validated or not but also to choose the most optimal assembly sequence that ensures the best operation quality. A validation example of a speed reducer is used to demonstrate the added value of the proposed approach.


Author(s):  
Vanessa Las Heras ◽  
Silvia Melgar ◽  
John MacSharry ◽  
Cormac G.M. Gahan

Diet exerts a major influence upon host immune function and the gastrointestinal microbiota. Although components of the human diet (including carbohydrates, fats, and proteins) are essential sources of nutrition for the host, they also influence immune function directly through interaction with innate and cell-mediated immune regulatory mechanisms. Regulation of the microbiota community structure also provides a mechanism by which food components influence host immune regulatory processes. Here, we consider the complex interplay between components of the modern (Western) diet, the microbiota, and host immunity in the context of obesity and metabolic disease, inflammatory bowel disease, and infection. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 13 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.


2022 ◽  
Vol 5 (1) ◽  
pp. 116-123
Author(s):  
Yola Tri Handika ◽  
Sarjon Defit ◽  
Gunadi Widi Nurcahyo

Hoax news (hocus to trick) has a very big influence in disseminating information, especially in the world of social media. News has an important impact on social and political conditions, and news can move the economy of a country. For this reason, it is necessary to have an analysis to classify hoax news and not hoaxes, and have high accuracy in classifying the news. In this study, two methods were used as a comparison in achieving high accuracy, namely the Naïve Bayes method which is famous for having high accuracy in classification with little data, and the C.45 method which can minimize noise in the data. The data used are 300 articles with 10 topics which contain hoax and non-hoax news. The data is obtained from the internet through social media, such as Twitter, Instagram and Facebook. Testing using the Naïve Bayes method has a higher accuracy than the C.45 method. The amount of data used has a major influence on the test results, if more data enters the training stage, then this study will have higher accuracy. However, the results of this test can be recommended to increase accuracy in the construction of a hoax news detection system.


2022 ◽  
Author(s):  
Barbara Luzia Santos de Oliveira Faro ◽  
Priscila Sanjuan de Medeiros-Sarmento ◽  
Norma Ely Santos Beltrão ◽  
Paulo Weslem Portal Gomes ◽  
Ana Cláudia Caldeira Tavares-Martins

Abstract Mangroves in the Amazon are influenced by several environmental conditions that determine the composition and structural development of the arboreal flora, which results in different distribution patterns. In this study, we sought to answer two questions: (1) what is the composition and structure of the mangroves near the mouth of the Amazon River in Marajó Island? (2) Are the fringe and inland mangroves more similar or dissimilar in terms of floristic composition? For this, we delimited a fringe zone and an inland zone about 1 km apart from each other. In each zone, we distributed five 400-m2 plots. The individuals were grouped into diameter and height classes and structural and phytosociological parameters were calculated. Ten species were recorded in the mangroves, of which seven are typical of white-water (várzea) and black-water (igapó) flooded forest ecosystems. We believed the adjacent ecosystems and the hydrological network are inducing the establishment of such species. The composition and structure of mangroves did not differ statistically between zones, and the degree of similarity may be a result of similar environmental factors in these zones such as low relief and high frequency of macrotides. We conclude that the vegetation of the studied mangroves has a major influence of the fluvial-marine system of the great rivers of the Amazon associated with a diversity of ecosystems that, together, generate greater floristic richness when compared to mangroves in other regions.


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