scholarly journals Successful treatment with imatinib after nilotinib and ipilimumab in a c-kit-mutated advanced melanoma patient

2017 ◽  
Vol 27 (4) ◽  
pp. 396-398 ◽  
Author(s):  
Carla Murer ◽  
Pascale Kränzlin-Stieger ◽  
Lars E. French ◽  
Reinhard Dummer ◽  
Simone M. Goldinger
Keyword(s):  
Successful Treatment ◽  
Melanoma Patient ◽  
Advanced Melanoma ◽  
Advanced Melanoma Patient

Severe rhabdomyolysis developing in an advanced melanoma patient treated by pembrolizumab followed by dabrafenib trametinib combined therapy

2019 ◽  
Vol 46 (7) ◽  
Author(s):  
Moyuka Irimada ◽  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Akira Tsukada ◽  
Toshiya Takahashi ◽  
...  
Keyword(s):  
Melanoma Patient ◽  
Combined Therapy ◽  
Advanced Melanoma ◽  
Advanced Melanoma Patient

scholarly journals Successful Treatment of Nivolumab-Resistant Multiple In-Transit Melanomas with Ipilimumab and Topical Imiquimod

2018 ◽  
Vol 11 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Yota Sato ◽  
Kayo Tanita ◽  
Sadanori Furudate ◽  
...  
Keyword(s):  
Successful Treatment ◽  
Antibody Therapy ◽  
Supportive Therapy ◽  
Advanced Melanoma ◽  
The Other ◽  
Antitumor Effects ◽  
Topical Imiquimod ◽  
Resistant Patient ◽  
Melanoma Patients ◽  
In Transit

Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. In this report, we describe a case of multiple in-transit melanomas developing in a nivolumab-resistant patient successfully treated with ipilimumab in combination with imiquimod. Our present case suggested a possible therapy for nivolumab-resistant multiple in-transit melanomas using ipilimumab in combination with topical imiquimod.

scholarly journals Sarcoidosis-like disease mimicking metastases during adjuvant ipilimumab therapy in advanced melanoma patient: CT scan and MRI help in managing difficult clinical decision

2020 ◽  
Vol 6 (2) ◽  
pp. 20190065
Author(s):  
Enrico Matteo Garanzini ◽  
Davide Scaramuzza ◽  
Gaia Spadarella ◽  
Lorenza Di Guardo ◽  
Alfonso Marchianò
Keyword(s):  
Blood Test ◽  
Clinical Decision ◽  
Advanced Melanoma ◽  
Complete Regression ◽  
Immunomodulatory Drugs ◽  
Left Forearm ◽  
Adjuvant Setting ◽  
Radiological Features ◽  
Advanced Melanoma Patient

The onset of an autoimmune, sarcoidosis-like reaction during or after treatment with immunomodulatory drugs as Ipilimumab is an atypical but renowned eventuality. Awareness of this scenario and its radiological features helps the Radiologist to avoid misdiagnosis of disease progression. In this case report, we present a patient operated for advanced cutaneous melanoma of the left forearm who developed hilar adenopathies with lung and splenic nodules during therapy with Ipilimumab in adjuvant setting. These findings were at first referred to as disease recurrences. Based on discrepancies between imaging, clinic and blood test findings we decided to put the patient on strict follow-up which showed a spontaneous complete regression on the visceral lesions few months after Ipilimumab withheld.

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