The Association Between Anal Function and Neural Degeneration After Preoperative Chemoradiotherapy Followed by Intersphincteric Resection

Operating on low rectal cancer by performing an intersphincteric resection (ISR) with coloanal anastomosis has been adopted as an alternative to abdominoperineal excision (APE) following Schiessel et al. report in 1994, as it preserves the sphincter and avoids the need for a permanent stoma. We undertook a review of the recent literature specifically focusing on long-term oncologic and functional outcomes of ISR to evaluate whether this operation is a valid alternative to an APE. In conclusion, younger patients with T1 or T2 rectal cancers who require no preoperative therapy are ideal candidates for ISR, given that preoperative chemoradiotherapy may cause long-term severe anal dysfunction after ISR.

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The Impact of Anastomotic Leakage on Anal Function Following Intersphincteric Resection

World Journal of Surgery ◽

10.1007/s00268-017-3960-4 ◽

2017 ◽

Vol 41 (8) ◽

pp. 2168-2177 ◽

Cited By ~ 11

Author(s):

Mitsuru Yokota ◽

Masaaki Ito ◽

Yuji Nishizawa ◽

Akihiro Kobayashi ◽

Norio Saito

Keyword(s):

Anastomotic Leakage ◽

Intersphincteric Resection ◽

Anal Function ◽

The Impact

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Anal function-preserving subtotal intersphincteric resection/partial external sphincteric resection with hybrid 2-port hand-assisted laparoscopic surgery (Mukai's operation) for very low stage I rectal cancer: A case report

Oncology Letters ◽

10.3892/ol.2011.327 ◽

2011 ◽

Cited By ~ 2

Author(s):

Masaya Mukai

Keyword(s):

Rectal Cancer ◽

Case Report ◽

Laparoscopic Surgery ◽

Intersphincteric Resection ◽

Stage I ◽

Anal Function

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Analysis of Clinical Factors Associated with Anal Function after Intersphincteric Resection for Very Low Rectal Cancer

Diseases of the Colon & Rectum ◽

10.1007/dcr.0b013e31819739a0 ◽

2009 ◽

Vol 52 (1) ◽

pp. 64-70 ◽

Cited By ~ 84

Author(s):

Masaaki Ito ◽

Norio Saito ◽

Masanori Sugito ◽

Akihiro Kobayashi ◽

Yusuke Nishizawa ◽

...

Keyword(s):

Rectal Cancer ◽

Intersphincteric Resection ◽

Low Rectal Cancer ◽

Clinical Factors ◽

Anal Function ◽

Factors Associated ◽

Very Low Rectal Cancer

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Clinical efficacy of intersphincteric resection for low rectal cancer compared with abdominoperineal resection: a single-center retrospective study

10.21203/rs.3.rs-26040/v1 ◽

2020 ◽

Author(s):

Baifu Peng ◽

Zixin Wu ◽

Zijian He ◽

Guanwei Li ◽

Jie Cao ◽

...

Keyword(s):

Rectal Cancer ◽

Abdominoperineal Resection ◽

Clinical Efficacy ◽

Intersphincteric Resection ◽

Low Rectal Cancer ◽

Anal Function ◽

Soft Diet ◽

Lars Score ◽

Feasible Alternative ◽

Hospital Stays

Abstract Purpose In recent years, intersphincteric resection (ISR) has been increasingly used to replace abdominoperineal resection (APR) for low rectal cancer. This study was to compare the clinical efficacy of ISR and APR. Methods Between 2012 and 2018, 74 consecutive patients with low rectal cancer underwent ISR and APR in our medical centre. The outcomes were retrospectively studied and compared. Results A total of 43 patients underwent ISR and 31 underwent APR were included in the study. No significant differences were found between two groups in gender, age, BMI and ASA score. ISR group showed shorter operative time (P = 0.02) and less blood loss (P = 0.001). Hospital stays, time to soft diet, and postoperative thirty-day complications were not significantly different between the two groups. As for the long-term outcomes, the survival and recurrence rate were similar between two groups. Moreover, LARS score and Wexner score showed the anal function after ISR was generally satisfactory. Conclusion This study suggested that ISR may provide a feasible alternative to APR, with superior short-term outcomes, similar oncological outcomes and satisfactory postoperative anal function.

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