The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior

2007 ◽  
Vol 18 (5-6) ◽  
pp. 391-418 ◽  
Author(s):  
Heath D. Schmidt ◽  
Ronald S. Duman
Keyword(s):  
Animal Models ◽  
Neurotrophic Factors ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Antidepressant Treatments

scholarly journals Role of adult hippocampal neurogenesis in the antidepressant actions of lactate

2021 ◽  
Author(s):  
Anthony Carrard ◽  
Frédéric Cassé ◽  
Charline Carron ◽  
Sophie Burlet-Godinot ◽  
Nicolas Toni ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Animal Models ◽  
Memory Consolidation ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Signaling Molecule ◽  
Energy Substrate ◽  
Antidepressant Effects ◽  
Adult Hippocampus

AbstractIn addition to its role as a neuronal energy substrate and signaling molecule involved in synaptic plasticity and memory consolidation, recent evidence shows that lactate produces antidepressant effects in animal models. However, the mechanisms underpinning lactate’s antidepressant actions remain largely unknown. In this study, we report that lactate reverses the effects of corticosterone on depressive-like behavior, as well as on the inhibition of both the survival and proliferation of new neurons in the adult hippocampus. Furthermore, the inhibition of adult hippocampal neurogenesis prevents the antidepressant-like effects of lactate. Pyruvate, the oxidized form of lactate, did not mimic the effects of lactate on adult hippocampal neurogenesis and depression-like behavior. Finally, our data suggest that conversion of lactate to pyruvate with the concomitant production of NADH is necessary for the neurogenic and antidepressant effects of lactate.

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

2021 ◽  
Vol 28 ◽  
Author(s):  
Lucas Alexandre Santos Marzano ◽  
Fabyolla Lúcia Macedo de Castro ◽  
Caroline Amaral Machado ◽  
João Luís Vieira Monteiro de Barros ◽  
Thiago Macedo e Cordeiro ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Studies ◽  
Molecular Mechanisms ◽  
Hippocampal Neurogenesis ◽  
Cognitive Outcomes ◽  
Adult Hippocampal Neurogenesis ◽  
The Brain

: Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

scholarly journals Role of Neuronal Ras Activity in Adult Hippocampal Neurogenesis and Cognition

2011 ◽  
Vol 5 ◽  
Author(s):  
Martina Manns ◽  
Oliver Leske ◽  
Sebastian Gottfried ◽  
Zoë Bichler ◽  
Pauline Lafenêtre ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

2020 ◽  
Vol 8 ◽  
Author(s):  
Sebastian B. Arredondo ◽  
Daniela Valenzuela-Bezanilla ◽  
Muriel D. Mardones ◽  
Lorena Varela-Nallar
Keyword(s):  
Wnt Signaling ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Health And Disease

scholarly journals Role of adult hippocampal neurogenesis in persistent pain

Pain ◽  
2016 ◽  
Vol 157 (2) ◽  
pp. 418-428 ◽  
Author(s):  
A. Vania Apkarian ◽  
Amelia A. Mutso ◽  
Maria V. Centeno ◽  
Lixin Kan ◽  
Melody Wu ◽  
...  
Keyword(s):  
Persistent Pain ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Neuron ◽  
2017 ◽  
Vol 93 (3) ◽  
pp. 560-573.e6 ◽  
Author(s):  
Ruth Beckervordersandforth ◽  
Birgit Ebert ◽  
Iris Schäffner ◽  
Jonathan Moss ◽  
Christian Fiebig ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Mitochondrial Metabolism ◽  
Adult Hippocampal Neurogenesis
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