Role of Adult Hippocampal Neurogenesis in Cognition in Physiology and Disease: Pharmacological Targets and Biomarkers

2015 ◽  
pp. 99-155 ◽  
Author(s):  
Veronica Costa ◽  
Sebastian Lugert ◽  
Ravi Jagasia
Keyword(s):  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Pharmacological Targets

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

2021 ◽  
Vol 28 ◽  
Author(s):  
Lucas Alexandre Santos Marzano ◽  
Fabyolla Lúcia Macedo de Castro ◽  
Caroline Amaral Machado ◽  
João Luís Vieira Monteiro de Barros ◽  
Thiago Macedo e Cordeiro ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Studies ◽  
Molecular Mechanisms ◽  
Hippocampal Neurogenesis ◽  
Cognitive Outcomes ◽  
Adult Hippocampal Neurogenesis ◽  
The Brain

: Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

scholarly journals Role of Neuronal Ras Activity in Adult Hippocampal Neurogenesis and Cognition

2011 ◽  
Vol 5 ◽  
Author(s):  
Martina Manns ◽  
Oliver Leske ◽  
Sebastian Gottfried ◽  
Zoë Bichler ◽  
Pauline Lafenêtre ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

2020 ◽  
Vol 8 ◽  
Author(s):  
Sebastian B. Arredondo ◽  
Daniela Valenzuela-Bezanilla ◽  
Muriel D. Mardones ◽  
Lorena Varela-Nallar
Keyword(s):  
Wnt Signaling ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Health And Disease

scholarly journals Role of adult hippocampal neurogenesis in persistent pain

Pain ◽  
2016 ◽  
Vol 157 (2) ◽  
pp. 418-428 ◽  
Author(s):  
A. Vania Apkarian ◽  
Amelia A. Mutso ◽  
Maria V. Centeno ◽  
Lixin Kan ◽  
Melody Wu ◽  
...  
Keyword(s):  
Persistent Pain ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Neuron ◽  
2017 ◽  
Vol 93 (3) ◽  
pp. 560-573.e6 ◽  
Author(s):  
Ruth Beckervordersandforth ◽  
Birgit Ebert ◽  
Iris Schäffner ◽  
Jonathan Moss ◽  
Christian Fiebig ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Mitochondrial Metabolism ◽  
Adult Hippocampal Neurogenesis

scholarly journals Reproduction-Associated Hormones and Adult Hippocampal Neurogenesis

2021 ◽  
Vol 2021 ◽  
pp. 1-20
Author(s):  
Lily Wan ◽  
Rou-Jie Huang ◽  
Zhao-Hui Luo ◽  
Jiao-e Gong ◽  
Aihua Pan ◽  
...  
Keyword(s):  
Functional Significance ◽  
Potential Role ◽  
Brain Plasticity ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Pregnancy And Postpartum

The levels of reproduction-associated hormones in females, such as estrogen, progesterone, prolactin, and oxytocin, change dramatically during pregnancy and postpartum. Reproduction-associated hormones can affect adult hippocampal neurogenesis (AHN), thereby regulating mothers' behavior after delivery. In this review, we first briefly introduce the overall functional significance of AHN and the methods commonly used to explore this front. Then, we attempt to reconcile the changes of reproduction-associated hormones during pregnancy. We further update the findings on how reproduction-related hormones influence adult hippocampal neurogenesis. This review is aimed at emphasizing a potential role of AHN in reproduction-related brain plasticity and its neurobiological relevance to motherhood behavior.

Sign in / Sign up

Export Citation Format

Share Document