scholarly journals The Role of Adult Hippocampal Neurogenesis in Learning and Memory Function

2016 ◽  
Vol 22 (4) ◽  
pp. 149-155 ◽  
Author(s):  
Zülal Kaptan ◽  
Gülay Üzüm
Keyword(s):  
Learning And Memory ◽  
Memory Function ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Tau Pathology and Adult Hippocampal Neurogenesis: What Tau Mouse Models Tell us?

2021 ◽  
Vol 12 ◽  
Author(s):  
Sarah Houben ◽  
Mégane Homa ◽  
Zehra Yilmaz ◽  
Karelle Leroy ◽  
Jean-Pierre Brion ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Mouse Models ◽  
Physiological Role ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Tau Proteins ◽  
Tau Pathology ◽  
Brain Areas ◽  
The Relationship

Adult hippocampal neurogenesis (AHN) has been widely confirmed in mammalian brains. A growing body of evidence points to the fact that AHN sustains hippocampal-dependent functions such as learning and memory. Impaired AHN has been reported in post-mortem human brain hippocampus of Alzheimer's disease (AD) and is considered to contribute to defects in learning and memory. Neurofibrillary tangles (NFTs) and amyloid plaques are the two key neuropathological hallmarks of AD. NFTs are composed of abnormal tau proteins accumulating in many brain areas during the progression of the disease, including in the hippocampus. The physiological role of tau and impact of tau pathology on AHN is still poorly understood. Modifications in AHN have also been reported in some tau transgenic and tau-deleted mouse models. We present here a brief review of advances in the relationship between development of tau pathology and AHN in AD and what insights have been gained from studies in tau mouse models.

Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

2021 ◽  
Vol 28 ◽  
Author(s):  
Lucas Alexandre Santos Marzano ◽  
Fabyolla Lúcia Macedo de Castro ◽  
Caroline Amaral Machado ◽  
João Luís Vieira Monteiro de Barros ◽  
Thiago Macedo e Cordeiro ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Clinical Studies ◽  
Molecular Mechanisms ◽  
Hippocampal Neurogenesis ◽  
Cognitive Outcomes ◽  
Adult Hippocampal Neurogenesis ◽  
The Brain

: Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

scholarly journals Role of Neuronal Ras Activity in Adult Hippocampal Neurogenesis and Cognition

2011 ◽  
Vol 5 ◽  
Author(s):  
Martina Manns ◽  
Oliver Leske ◽  
Sebastian Gottfried ◽  
Zoë Bichler ◽  
Pauline Lafenêtre ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Deltamethrin Exposure Inhibits Adult Hippocampal Neurogenesis and Causes Deficits in Learning and Memory in Mice

2020 ◽  
Vol 178 (2) ◽  
pp. 347-357
Author(s):  
Muhammad M Hossain ◽  
Abdelmadjid Belkadi ◽  
Sara Al-Haddad ◽  
Jason R Richardson
Keyword(s):  
Object Recognition ◽  
Learning And Memory ◽  
Water Maze ◽  
Cellular Proliferation ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Novel Object Recognition ◽  
Short Term ◽  
Novel Object ◽  
Short Term Exposure

Abstract Deficits in learning and memory are often associated with disruption of hippocampal neurogenesis, which is regulated by numerous processes, including precursor cell proliferation, survival, migration, and differentiation to mature neurons. Recent studies demonstrate that adult born neurons in the dentate gyrus (DG) in the hippocampus can functionally integrate into the existing neuronal circuitry and contribute to hippocampal-dependent learning and memory. Here, we demonstrate that relatively short-term deltamethrin exposure (3 mg/kg every 3 days for 1 month) inhibits adult hippocampal neurogenesis and causes deficits in learning and memory in mice. Hippocampal-dependent cognitive functions were evaluated using 2 independent hippocampal-dependent behavioral tests, the novel object recognition task and Morris water maze. We found that deltamethrin-treated mice exhibited profound deficits in novel object recognition and learning and memory in water maze. Deltamethrin exposure significantly decreased bromodeoxyuridine (BrdU)-positive cells (39%) and Ki67+ cells (47%) in the DG of the hippocampus, indicating decreased cellular proliferation. In addition, deltamethrin-treated mice exhibited a 44% decrease in nestin-expressing neural progenitor cells and a 38% reduction in the expression of doublecortin (DCX), an early neuronal differentiation marker. Furthermore, deltamethrin-exposed mice exhibited a 25% reduction in total number of granule cells in the DG. These findings indicate that relatively short-term exposure to deltamethrin causes significant deficits in hippocampal neurogenesis that is associated with impaired learning and memory.

scholarly journals Role of Wnt Signaling in Adult Hippocampal Neurogenesis in Health and Disease

2020 ◽  
Vol 8 ◽  
Author(s):  
Sebastian B. Arredondo ◽  
Daniela Valenzuela-Bezanilla ◽  
Muriel D. Mardones ◽  
Lorena Varela-Nallar
Keyword(s):  
Wnt Signaling ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Health And Disease

scholarly journals Role of adult hippocampal neurogenesis in persistent pain

Pain ◽  
2016 ◽  
Vol 157 (2) ◽  
pp. 418-428 ◽  
Author(s):  
A. Vania Apkarian ◽  
Amelia A. Mutso ◽  
Maria V. Centeno ◽  
Lixin Kan ◽  
Melody Wu ◽  
...  
Keyword(s):  
Persistent Pain ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

Neuron ◽  
2017 ◽  
Vol 93 (3) ◽  
pp. 560-573.e6 ◽  
Author(s):  
Ruth Beckervordersandforth ◽  
Birgit Ebert ◽  
Iris Schäffner ◽  
Jonathan Moss ◽  
Christian Fiebig ◽  
...  
Keyword(s):  
Hippocampal Neurogenesis ◽  
Mitochondrial Metabolism ◽  
Adult Hippocampal Neurogenesis
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