Maternal exposure to daidzein alters behaviour and oestrogen receptor α expression in adult female offspring

2010 ◽  
Vol 21 (4) ◽  
pp. 283-291 ◽  
Author(s):  
Chengjun Yu ◽  
Fadao Tai ◽  
Ruiyong Wu ◽  
Zhenzhen Song ◽  
Xia Zhang ◽  
...  
Keyword(s):  
Adult Female ◽  
Oestrogen Receptor ◽  
Female Offspring ◽  
Maternal Exposure ◽  
Oestrogen Receptor Α

MATERNAL EXPOSURE TO DDE MAY INCREASE WEIGHT AND BODY-MASS IN ADULT FEMALE OFFSPRING

Epidemiology ◽  
2004 ◽  
Vol 15 (4) ◽  
pp. S117-S118 ◽  
Author(s):  
Wilfried Karmaus ◽  
Ihuoma Eneli
Keyword(s):  
Body Mass ◽  
Adult Female ◽  
Female Offspring ◽  
Maternal Exposure

Oestrogen receptor α promotes prostate cancer progression through dual actions in both epithelia and stroma

2015 ◽  
Author(s):  
Mitchell Lawrence ◽  
Ruth Pidsley ◽  
Stuart Ellem ◽  
Luc Furic ◽  
Shalima Nair ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Oestrogen Receptor ◽  
Prostate Cancer Progression ◽  
Oestrogen Receptor Α

scholarly journals Effects of exogenous adiponectin supplementation in early pregnant PCOS mice on the metabolic syndrome of adult female offspring

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Meng Zuo ◽  
Guotao Liao ◽  
Wenqian Zhang ◽  
Dan Xu ◽  
Juan Lu ◽  
...  
Keyword(s):  
Adult Female ◽  
Early Pregnancy ◽  
Testosterone Level ◽  
Metabolic Disorders ◽  
Serum Testosterone ◽  
Female Offspring ◽  
Metabolic Phenotype ◽  
Serum Testosterone Level ◽  
The Metabolic Syndrome ◽  
Pcos Group

Abstract Objective PCOS is a heterogeneous endocrine disorder with both reproductive and metabolic abnormalities. At present, PCOS has been confirmed to have a certain genetic background. Compared with healthy women, the vast majority of PCOS patients have hyperandrogenemia, and this excessive androgen exposure during pregnancy may affect the development of female fetuses. The aim of the current study was to investigate the effect of adiponectin intervention during early pregnancy of obese mice with PCOS on the metabolic phenotype of adult female offspring. Methods After the PCOS model was established, C57BL/6J mice were divided into maternal-control, maternal-PCOS, and maternal-PCOS + APN groups. DHEA-induced PCOS mice were supplemented with adiponectin (10 mg/kg/day) in the early pregnancy in order to eliminate adverse hormone exposure and then traced for endocrine indicators in their adult female offspring, which were observed for metabolism syndrome or endocrine disturbance and exhibited the main effects of APN. To further explore the underlying mechanism, the relative expressions of phosphorylated AMPK, PI3K, and Akt were detected in the ovaries of offspring mice. Results The serum testosterone level of the maternal-PCOS + APN group in early pregnancy was significantly lower than that of the maternal-PCOS group (p < 0.01). The serum testosterone level in the offspring-PCOS + APN group was significantly lower than in the offspring-PCOS group (p <0.05), the diestrus time characterized by massive granulocyte aggregation in the estrus cycle was significantly shorter than in the offspring-PCOS group (p<0.05), and the phenotypes of PCOS-like reproductive disorders and metabolic disorders, such as obesity, insulin resistance, impaired glucose tolerance, and hyperlipidemia, were also significantly improved in the offspring-PCOS + APN group (p < 0.05). Compared with the control group, the expression levels of phosphorylated AMPK, PI3K, and Akt in the offspring-PCOS group were significantly decreased (p < 0.05), while those in the offspring-PCOS + APN group were significantly increased (p < 0.05). Conclusions APN intervention in early pregnancy significantly reduced the adverse effects of maternal obesity and high androgen levels during pregnancy on female offspring and corrected the PCOS-like endocrine phenotype and metabolic disorders of adult female offspring. This effect may be caused by the activation of the AMPK/PI3K-Akt signaling pathway in PCOS offspring mice.

Oestrogen Receptor α in the Heart is Critical for Protection Against Systemic Obesity in Female Mice

2021 ◽  
Vol 30 ◽  
pp. S123
Author(s):  
Y. Tham ◽  
B. Bernardo ◽  
L. Woon ◽  
S. Yildiz ◽  
C. Tai ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Female Mice ◽  
Oestrogen Receptor Α

scholarly journals Sex Differences in Expression of Oestrogen Receptor α but not Androgen Receptor mRNAs in the Foetal Lamb Brain

2014 ◽  
Vol 26 (5) ◽  
pp. 321-328 ◽  
Author(s):  
R. C. Reddy ◽  
C. T. Estill ◽  
M. Meaker ◽  
F. Stormshak ◽  
C. E. Roselli
Keyword(s):  
Sex Differences ◽  
Androgen Receptor ◽  
Oestrogen Receptor ◽  
Oestrogen Receptor Α ◽  
Receptor Mrnas ◽  
Foetal Lamb

scholarly journals Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Stéphanie Cagnet ◽  
Dalya Ataca ◽  
George Sflomos ◽  
Patrick Aouad ◽  
Sonia Schuepbach-Mallepell ◽  
...  
Keyword(s):  
Cell Population ◽  
Oestrogen Receptor ◽  
Mammary Epithelium ◽  
Oestrogen Receptor Α
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