Platelet Reactivity in Patients on Aspirin and Clopidogrel Therapy Measured by a New Bedside Whole-Blood Assay

2019 ◽  
Vol 73 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Amin Polzin ◽  
Carolin Helten ◽  
Lisa Dannenberg ◽  
Philipp Mourikis ◽  
David Naguib ◽  
...  
Keyword(s):  
Whole Blood ◽  
Platelet Reactivity ◽  
Whole Blood Assay ◽  
Blood Assay ◽  
Clopidogrel Therapy

scholarly journals Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction

Blood ◽  
2015 ◽  
Vol 126 (10) ◽  
pp. e11-e18 ◽  
Author(s):  
Paul C. J Armstrong ◽  
Nicholas S. Kirkby ◽  
Melissa V. Chan ◽  
Michaela Finsterbusch ◽  
Nancy Hogg ◽  
...  
Keyword(s):  
High Throughput ◽  
Whole Blood ◽  
Platelet Reactivity ◽  
Research Application ◽  
Whole Blood Assay ◽  
Blood Assay ◽  
Fibrinogen Binding ◽  
Key Points ◽  
Low Volume ◽  
Whole Blood Aggregometry

Key PointsLow-volume, high-throughput whole blood aggregometry will facilitate future mouse platelet function research. Application of this approach identifies ICAM-1 as a novel mediator of platelet-monocyte interaction through fibrinogen binding.

Non-Thrombogenicity of Clean Glass Revealed by Native Whole Blood Assay in Bead Columns

1983 ◽  
Vol 50 (04) ◽  
pp. 814-820 ◽  
Author(s):  
J A Bergeron ◽  
J M DiNovo ◽  
A F Razzano ◽  
W J Dodds
Keyword(s):  
Whole Blood ◽  
Glass Bead ◽  
Factor Xii ◽  
Platelet Factor ◽  
Serotonin Content ◽  
Whole Blood Assay ◽  
Vascular Integrity ◽  
Blood Assay ◽  
Standard Contact ◽  
Recalcification Time

SummaryThe previously described native whole blood assay for materials in solution or suspension has been adapted to materials in a bead column configuration. These experiments showed that the glass itself accounts for little or none of the high blood-reactivity observed with conventional glass bead columns. Columns composed solely of soft glass that was “cleaned” by heat treatment (500-595° C 18 hr, electric oven) were benign toward flowing native whole blood for all variables measured (platelet count and platelet-free plasma [C14]-serotonin content, platelet factor 3 and factor XII activities, and recalcification time) with the standard contact protocol. In addition, the effluent successfully maintained perfusion of the isolated kidney, a measure of the ability of platelets to support vascular integrity. Prolonged (30 min) normothermic contact with titrated whole blood increased the subsequent reactivity of initially clean glass toward whole blood albeit to a level much less than that of conventional glass bead columns.

Whole Blood Assay: Thromboelastometry – Bleeding Management Algorithms

2021 ◽  
pp. 67-87
Author(s):  
Klaus Görlinger ◽  
James Iqbal ◽  
Daniel Dirkmann ◽  
Kenichi A. Tanaka
Keyword(s):  
Whole Blood ◽  
Whole Blood Assay ◽  
Bleeding Management ◽  
Blood Assay ◽  
Management Algorithms

scholarly journals Analysis of the dynamics of Staphylococcus aureus binding to white blood cells using whole blood assay and geno-to-pheno mapping

2020 ◽  
Vol 310 (3) ◽  
pp. 151411
Author(s):  
Daria Gaidar ◽  
Alice Jonas ◽  
Ruslan Akulenko ◽  
Ulla Ruffing ◽  
Mathias Herrmann ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Whole Blood ◽  
Blood Cells ◽  
White Blood Cells ◽  
Whole Blood Assay ◽  
Blood Assay

IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay

2019 ◽  
Vol 309 (5) ◽  
pp. 299-306 ◽  
Author(s):  
Ivana Palucci ◽  
Basem Battah ◽  
Alessandro Salustri ◽  
Flavio De Maio ◽  
Linda Petrone ◽  
...  
Keyword(s):  
Whole Blood ◽  
Ex Vivo ◽  
Whole Blood Assay ◽  
Blood Assay ◽  
Mycobacterial Growth
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