Sacubitril/valsartan in the treatment of right ventricular dysfunction in patients with heart failure with reduced ejection fraction

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ying Yang ◽  
Chao Shen ◽  
Jiangting Lu ◽  
Guosheng Fu ◽  
Cui Xiong
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

scholarly journals Right ventricular dysfunction predict limited exercise capacity in heart failure with reduced ejection fraction

2013 ◽  
Vol 8 (5-6) ◽  
pp. 190-190
Author(s):  
Pranvera Ibrahimi ◽  
Gani Bajraktari ◽  
Afrim Poniku ◽  
Violeta Hysenaj ◽  
Artan Ahmeti ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Exercise Capacity ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Reduced Ejection Fraction

scholarly journals Right ventricular dysfunction in left-sided heart failure with preserved versus reduced ejection fraction

2017 ◽  
Vol 19 (12) ◽  
pp. 1664-1671 ◽  
Author(s):  
Lena Bosch ◽  
Carolyn S.P. Lam ◽  
Lingli Gong ◽  
Siew Pang Chan ◽  
David Sim ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Reduced Ejection Fraction

scholarly journals Forgotten No More—The Role of Right Ventricular Dysfunction in Heart Failure with Reduced Ejection Fraction: An Echocardiographic Perspective

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 548
Author(s):  
Aura Vijiiac ◽  
Sebastian Onciul ◽  
Claudia Guzu ◽  
Alina Scarlatescu ◽  
Ioana Petre ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Functional Assessment ◽  
Ventricular Dysfunction ◽  
Right Ventricular Dysfunction ◽  
Reduced Ejection Fraction ◽  
The Right

During the last decade, studies have raised awareness of the crucial role that the right ventricle plays in various clinical settings, including diseases primarily linked to the left ventricle. The assessment of right ventricular performance with conventional echocardiography is challenging. Novel echocardiographic techniques improve the functional assessment of the right ventricle and they show good correlation with the gold standard represented by cardiac magnetic resonance. This review summarizes the traditional and innovative echocardiographic techniques used in the functional assessment of the right ventricle, focusing on the role of right ventricular dysfunction in heart failure with reduced ejection fraction and providing a perspective on recent evidence from literature.

scholarly journals Effects of Sacubitril/Valsartan on the Right Ventricular Arterial Coupling in Patients with Heart Failure with Reduced Ejection Fraction

2020 ◽  
Vol 9 (10) ◽  
pp. 3159
Author(s):  
Daniele Masarone ◽  
Vittoria Errigo ◽  
Enrico Melillo ◽  
Fabio Valente ◽  
Rita Gravino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Pulmonary Artery ◽  
Right Ventricle ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Reduced Ejection Fraction ◽  
Patients With Heart Failure

Background: right ventricle-pulmonary artery (RV-PA) coupling assessed by measuring the tricuspid anular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio has been recently proposed as an early marker of right ventricular dysfunction in patients with heart failure with a reduced ejection fraction (HFrEF). Methods: As the effects of sacubitril/valsartan therapy on RV-PA coupling remain unknown, this study aimed to analyse the effect of this drug on TAPSE/PASP in patients with HFrEF. We retrospectively analysed all outpatients with HFrEF referred to our unit between October 2016 and July 2018. Results: At the 1-year follow-up, sacubitril/valsartan therapy was associated with a significant improvement in TAPSE (18.26 ± 3.7 vs. 19.6 ± 4.2 mm, p < 0.01), PASP (38.3 ± 15.7 vs. 33.7 ± 13.6, p < 0.05), and RV-PA coupling (0.57 ± 0.25 vs. 0.68 ± 0.30 p < 0.01). These improvements persisted at the 2-year follow-up. In the multivariable analysis, the improvement in the RV-PA coupling was independent of the left ventricular remodelling. Conclusions: in patients with HFrEF, sacubitril/valsartan improved the RV-PA coupling; however, further trials are necessary to evaluate the role of sacubitril/valsartan in the treatment of right ventricle (RV) dysfunction either associated or not associated with left ventricular dysfunction.

Right Heart Phenotype in Heart Failure With Preserved Ejection Fraction

2021 ◽  
Author(s):  
Marco Guazzi ◽  
Robert Naeije
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Right Ventricular ◽  
Ventricular Dysfunction ◽  
Imaging Techniques ◽  
Treatment Options ◽  
Right Ventricular Dysfunction ◽  
Preserved Ejection Fraction ◽  
Right Heart ◽  
The Right

The health burden of heart failure with preserved ejection fraction is increasingly recognized. Despite improvements in diagnostic algorithms and established knowledge on the clinical trajectory, effective treatment options for heart failure with preserved ejection fraction remain limited, mainly because of the high mechanistic heterogeneity. Diagnostic scores, big data, and phenomapping categorization are proposed as key steps needed for progress. In the meantime, advancements in imaging techniques combined to high-fidelity pressure signaling analysis have uncovered right ventricular dysfunction as a mediator of heart failure with preserved ejection fraction progression and as major independent determinant of poor outcome. This review summarizes the current understanding of the pathophysiology of right ventricular dysfunction in heart failure with preserved ejection fraction covering the different right heart phenotypes and offering perspectives on new treatments targeting the right ventricle in its function and geometry.

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