Fetal sex determines the impact of maternal PROGINS progesterone receptor polymorphism on maternal physiology during pregnancy

2009 ◽  
Vol 19 (9) ◽  
pp. 710-718 ◽  
Author(s):  
Berthold Hocher ◽  
You-Peng Chen ◽  
Ludwig Schlemm ◽  
Aline Burdack ◽  
Jian Li ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Fetal Sex ◽  
The Impact ◽  
Receptor Polymorphism

scholarly journals Fetal Sex and Maternal Risk of Gestational Diabetes Mellitus: The Impact of Having a Boy

Diabetes Care ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 844-851 ◽  
Author(s):  
Ravi Retnakaran ◽  
Caroline K. Kramer ◽  
Chang Ye ◽  
Simone Kew ◽  
Anthony J. Hanley ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fetal Sex ◽  
Maternal Risk ◽  
The Impact

Progesterone receptor polymorphism is associated with pelvic organ prolapse risk

2009 ◽  
Vol 88 (7) ◽  
pp. 835-838 ◽  
Author(s):  
Huey-Yi Chen ◽  
Ya-Wen Chung ◽  
Wei-Yong Lin ◽  
Wen-Chi Chen ◽  
Fuu-Jen Tsai ◽  
...  
Keyword(s):  
Pelvic Organ Prolapse ◽  
Progesterone Receptor ◽  
Pelvic Organ ◽  
Receptor Polymorphism

scholarly journals The impact of female fetal sex on preeclampsia and the maternal immune milieu

2018 ◽  
Vol 12 ◽  
pp. 53-57 ◽  
Author(s):  
Brandie D. Taylor ◽  
Roberta B. Ness ◽  
Mark A. Klebanoff ◽  
Gong Tang ◽  
James M. Roberts ◽  
...  
Keyword(s):  
Fetal Sex ◽  
The Impact

scholarly journals Rapid Impact of Progesterone on the Neuronal Growth Cone

Endocrinology ◽  
2013 ◽  
Vol 154 (10) ◽  
pp. 3784-3795 ◽  
Author(s):  
Laura Olbrich ◽  
Lisa Wessel ◽  
Ajeesh Balakrishnan-Renuka ◽  
Marion Böing ◽  
Beate Brand-Saberi ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Growth Cone ◽  
Progesterone Receptors ◽  
Laser Scanning Microscopy ◽  
Axonal Outgrowth ◽  
Neuronal Growth ◽  
Drg Neurons ◽  
Progesterone Treatment ◽  
Neuronal Growth Cone ◽  
The Impact

In the last two decades, sensory neurons and Schwann cells in the dorsal root ganglia (DRG) were shown to express the rate-limiting enzyme of the steroid synthesis, cytochrome P450 side-chain cleavage enzyme (P450scc), as well as the key enzyme of progesterone synthesis, 3β-hydroxysteroid dehydrogenase (3β-HSD). Thus, it was well justified to consider that DRG neurons similarly are able to synthesize progesterone de novo from cholesterol. Because direct progesterone effects on axonal outgrowth in peripheral neurons have not been investigated up to now, the present study provides the first insights into the impact of exogenous progesterone on axonal outgrowth in DRG neurons. Our studies including microinjection and laser scanning microscopy demonstrate morphological changes especially in the neuronal growth cones after progesterone treatment. Furthermore, we were able to detect a distinctly enhanced motility only a few minutes after the start of progesterone treatment using time-lapse imaging. Investigation of the cytoskeletal distribution in the neuronal growth cone before, during, and after progesterone incubation revealed a rapid reorganization of actin filaments. To get a closer idea of the underlying receptor mechanisms, we further studied the expression of progesterone receptors in DRG neurons using RT-PCR and immunohistochemistry. Thus, we could demonstrate for the first time that classical progesterone receptor (PR) A and B and the recently described progesterone receptor membrane component 1 (PGRMC1) are expressed in DRG neurons. Antagonism of the classical progesterone receptors by mifepristone revealed that the observed progesterone effects are transmitted through PR-A and PR-B.

The impact of fetal sex on prematurity in dichorial-diamniotic twin pregnancies after assisted reproduction

2008 ◽  
Vol 90 ◽  
pp. S209
Author(s):  
K. Klein ◽  
M. Stammler-Safar ◽  
E. Krampl ◽  
N. Gleicher ◽  
D. Barad ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Fetal Sex ◽  
The Impact ◽  
Twin Pregnancies

Biomarker Changes During Neoadjuvant Anastrozole, Tamoxifen, or the Combination: Influence of Hormonal Status and HER-2 in Breast Cancer—A Study from the IMPACT Trialists

2005 ◽  
Vol 23 (11) ◽  
pp. 2477-2492 ◽  
Author(s):  
Mitch Dowsett ◽  
Steve R. Ebbs ◽  
J. Michael Dixon ◽  
Anthony Skene ◽  
Clive Griffith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Treated Group ◽  
Growth Factor Signaling ◽  
Tumor Biopsy ◽  
Tamoxifen Group ◽  
Her 2 ◽  
The Difference ◽  
Induced Changes ◽  
The Impact

Purpose To investigate the relationships between biomarker changes in breast cancer during neoadjuvant (preoperative) endocrine therapy. Patients and Methods The IMPACT trial compared the preoperative use of tamoxifen with anastrozole alone or in combination in postmenopausal women (n = 330) with primary breast cancer. Biomarkers were measured in tumor biopsy specimens taken at baseline, and after 2 and 12 weeks of treatment. Results A decrease in the proliferation marker Ki67 occurred in the majority of patients: 52 (93%) of 56, 46 (85%) of 54, and 37 (84%) of 44 patients in the anastrozole, tamoxifen, and combination groups, respectively. There was a significantly greater suppression of Ki67 in the anastrozole-treated group than in the tamoxifen- or combination-treated groups, which is parallel to the greater efficacy seen for anastrozole over these two treatments in the Arimidex, Tamoxifen, Alone or in Combination adjuvant trial. A positive relationship was noted between estrogen-receptor level and Ki67 suppression in all patients. Ki67 was reduced to a greater extent in progesterone receptor-positive tumors compared with progesterone receptor-negative tumors. HER-2-negative tumors tended to show a greater reduction in Ki67 compared with HER-2-positive tumors, but the difference was only significant in the tamoxifen group after 2 weeks, and in the anastrozole group after 12 weeks. Conclusion These results confirm the value of Ki67 as a molecular marker, and provide information regarding the relationships between treatment-induced changes in Ki67 and other important biomarkers. Studies such as this should help integrate agents targeted at growth factor signaling with endocrine agents in breast cancer.

scholarly journals The impact of androgen receptor polymorphism and parental ethnicity on semen quality in young men from Latvia

2008 ◽  
Vol 31 (5) ◽  
pp. 477-482 ◽  
Author(s):  
J. Erenpreiss ◽  
I. Tsarev ◽  
A. Giwercman ◽  
Y. Giwercman
Keyword(s):  
Androgen Receptor ◽  
Semen Quality ◽  
Young Men ◽  
The Impact ◽  
Receptor Polymorphism

Impact of discordance in estrogen receptor, progesterone receptor, and Ki-67 after neoadjuvant chemotherapy in breast cancer on survival.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e12079-e12079
Author(s):  
Yu-Qin Ding ◽  
Xiaowen Ding ◽  
Kaijing Ding ◽  
Wen-Ming Cao ◽  
Dehong Zou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Neoadjuvant Chemotherapy ◽  
Progesterone Receptor ◽  
Statistical Significance ◽  
Ki 67 ◽  
Risk Of Death ◽  
Patient Prognosis ◽  
The Impact ◽  
Negative Conversion

e12079 Background: The expression status of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 antigen (Ki-67) divides breast cancer into different subtypes. Changes in these biomarkers during treatment alter the overall treatment decision and affect prognosis. To date, few studies have investigated the effects of changes in these biomarkers throughout neoadjuvant chemotherapy (NAC) on patient prognosis. Methods: A total of 482 patients who received NAC were enrolled. The expression of ER, PR and Ki-67 between pre- and posttherapy specimens was studied by immunohistochemical methods. Physical and imaging examinations based on the Response Evaluation Criteria in Solid Tumors guidelines version 1.1 were utilized to assess the treatment response. The impact of these biomarkers status changes on survival was then tested for statistical significance using a Cox proportional hazards regression model for univariate and multivariate analyses. Results: The rate of discordance for ER, PR and Ki-67 was 10.37%, 17.01% and 77.39%, respectively, in which the PR positive-to-negative conversion was the most common change. A statistically significant differential overall survival (OS) related to biomarkers status throughout NAC (P<.01) was noted. The risk of death in patients with a PR positive-to-negative conversion was 6.58 times greater than that of stable PR expression (P=.002). The risk of disease recurrence in patients with increased Ki-67 expression was 1.91 times greater than that of stable Ki-67 expression (P=.02). Furthermore, we validated both of them as independent predictors of poor prognosis. Conclusions: We concluded that inconsistent expression of biomarkers can significantly affect patient prognosis. We suggest that biomarkers investigations during NAC may potentially improve patient management and survival. Survival result that compared with concordance and discondance in ER, PR and Ki-67. (N=482).*P<.05. [Table: see text]

Sign in / Sign up

Export Citation Format

Share Document