“Nobody left behind”: the role of data registries in assisted reproductive technology

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

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The Role of Leukemia Inhibitory Factor / LIF Receptor in Endometrial Implantation in Patient With Assisted Reproductive Technology

International Journal of Pharmaceutical Research ◽

10.31838/ijpr/2020.sp1.245 ◽

2020 ◽

Vol 12 (sp1) ◽

Keyword(s):

Assisted Reproductive Technology ◽

Leukemia Inhibitory Factor ◽

Reproductive Technology ◽

Inhibitory Factor

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The Potential Applications of Peroxisome Proliferator-Activated ReceptorδLigands in Assisted Reproductive Technology

PPAR Research ◽

10.1155/2008/794814 ◽

2008 ◽

Vol 2008 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Jaou-Chen Huang

Keyword(s):

Assisted Reproductive Technology ◽

Reproductive Function ◽

Reproductive Technology ◽

Embryonic Cell ◽

Preimplantation Embryos ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Potential Applications ◽

And Function

Peroxisome proliferator-activated receptorδ(PPARδ, also known as PPARβ) has ubiquitous distribution and extensive biological functions. The reproductive function of PPARδwas first revealed in the uterus at the implantation site. Since then, PPARδand its ligand have been discovered in all reproductive tissues, including the gametes and the preimplantation embryos. PPARδin preimplantation embryos is normally activated by oviduct-derived PPARδligand. PPARδactivation is associated with an increase in embryonic cell proliferation and a decrease in programmed cell death (apoptosis). On the other hand, the role of PPARδand its ligand in gamete formation and function is less well understood. This review will summarize the reproductive functions of PPARδand project its potential applications in assisted reproductive technology.

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Role of autoantibodies in infertility, miscarriage, and assisted reproductive technology outcomes

Reproductive and Developmental Medicine ◽

10.4103/2096-2924.322829 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0

Author(s):

Ming-Qing Li ◽

Hui-Hui Shen ◽

Zhen-Zhen Lai ◽

Hui-Li Yang ◽

Jia-Wei Shi

Keyword(s):

Assisted Reproductive Technology ◽

Reproductive Technology

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The role of various factors affecting the endometrium in enhancing the effectiveness of assisted reproductive technology programs

Akusherstvo i ginekologiia ◽

10.18565/aig.2021.1.28-34 ◽

2021 ◽

Vol 1_2021 ◽

pp. 28-34

Author(s):

Gokhberg Ya.A. Gokhberg ◽

Makarova N.P. Makarova ◽

Babayan A.A. Babayan ◽

Kalinina E.A. Kalinina ◽

Keyword(s):

Assisted Reproductive Technology ◽

Reproductive Technology ◽

Factors Affecting ◽

Technology Programs

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The Role of Acupuncture in Assisted Reproductive Technology

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2012/543924 ◽

2012 ◽

Vol 2012 ◽

pp. 1-15 ◽

Cited By ~ 13

Author(s):

Cui Hong Zheng ◽

Ming Min Zhang ◽

Guang Ying Huang ◽

Wei Wang

Keyword(s):

Assisted Reproductive Technology ◽

Meta Analysis ◽

Live Birth Rate ◽

Sham Acupuncture ◽

Reproductive Technology ◽

Laser Acupuncture ◽

Vitro Fertilization ◽

Positive Effects

The aim of this paper was to provide reliable evidence by performing a systematic review and meta-analysis for evaluating the role of acupuncture in assisted reproductive technology. All randomized controlled trials that evaluated the effects of acupuncture, including manual, electrical, and laser acupuncture (LA) techniques, on the clinical pregnancy rate (CPR) and live birth rate (LBR) of in vitro fertilization (IVF) or artificial insemination were included. The controlled groups consisted of no acupuncture and sham acupuncture groups. The sham acupuncture included sham acupuncture at acupoints, sham acupuncture at non- or inappropriate points, sham LA, and adhesive tapes. Twenty-three trials (a total of 5598 participants) were included in this paper. The pooled CPR from all acupuncture groups was significantly higher than that from all controlled groups, whereas the LBR was not significantly different between the two groups. However, the results were quite distinct when the type of control and/or different acupuncture times were examined in a sensitivity analysis. The results mainly indicate that acupuncture, especially around the time of the controlled ovarian hyperstimulation, improves pregnancy outcomes in women undergoing IVF. More positive effects from acupuncture in IVF can be expected if a more individualized acupuncture programs are used.

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