Association of Lifetime History of Traumatic Brain Injury With Prescription Opioid Use and Misuse Among Adults

Abstract Objective Examine factors associated with history of arrests and felony incarceration among Veterans and Service Members (V/SM) with combat exposure. Method Participants were V/SM who completed a baseline assessment for the multicenter Chronic Effects of Neurotrauma Consortium study (N = 1555). Most were male (87%), white (72%), with a mean age of 40 years (SD = 9.71). The majority (83%) reported a history of ≥1 mild traumatic brain injury (mTBI), with thirty-five present of those experiencing 3+ mTBIs. Results Three groups were composed based on self-reported level of involvement with the criminal justice system: 1.) No history of arrests or incarcerations (65%), 2.) A lifetime history of arrest but no felony incarceration (32%), and 3.) A lifetime history of felony incarceration (3%). Chi-square and Kruskal-Wallis H tests revealed statistically significant differences between the groups in demographic factors including the incarcerated group having younger age, greater percentage of men, lower education, and greater percentage of never being married, followed by the arrest group and then the no arrest group (all p < 0.05). The incarcerated group also had the highest level of posttraumatic stress disorder (PTSD) symptoms, lowest social support, and greatest percentage of hazardous alcohol consumption, followed by the arrest and then the no arrest groups (all p < 0.05). No differences were found between groups for mTBI history or neuropsychological testing results. Conclusions Correlates of legal involvement among V/SM span demographic and psychological dimensions. Some correlates are modifiable, including social support, PTSD symptoms, and alcohol consumption. Addressing these modifiable risk factors is critical to lower the risk of future criminal justice involvement.

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5 Lifetime history of traumatic brain injury and current disability among ohio adults

10.1136/injuryprev-2017-042560.5 ◽

2017 ◽

Author(s):

Honggang Yi ◽

John Corrigan ◽

Bhavna Singichetti ◽

Jennifer Bogner ◽

Kara Manchester ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Lifetime History ◽

History Of

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Prevalence of Lifetime History of Traumatic Brain Injury among Older Male Veterans Compared with Civilians: A Nationally Representative Study

Journal of Neurotrauma ◽

10.1089/neu.2020.7062 ◽

2020 ◽

Vol 37 (24) ◽

pp. 2680-2685

Author(s):

Erica S. Kornblith ◽

Kristine Yaffe ◽

Kenneth M. Langa ◽

Raquel C. Gardner

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Lifetime History ◽

Representative Study ◽

Male Veterans ◽

History Of ◽

Nationally Representative

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Current health status and history of traumatic brain injury among Ohio adults

Injury Prevention ◽

10.1136/injuryprev-2018-043056 ◽

2019 ◽

Vol 26 (2) ◽

pp. 129-137 ◽

Cited By ~ 2

Author(s):

Kara Manchester ◽

John D. Corrigan ◽

Bhavna Singichetti ◽

Lihong Huang ◽

Jennifer Bogner ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Poor Health ◽

Health Conditions ◽

Prior History ◽

Public Health Burden ◽

Lifetime History ◽

Adverse Health ◽

History Of ◽

The Relationship

IntroductionLifetime history of traumatic brain injury (TBI) with loss of consciousness (LOC) is prevalent in 21% of adult, non-institutionalised residents of Ohio. Prior history has been associated with lower incomes, inability to work and disability. The current study sought to evaluate the relationship between lifetime history and adverse health conditions.MethodsData came from the 2014 Ohio Behavioral Risk Factors Surveillance System, which included a state-specific module eliciting lifetime history of TBI.ResultsNon-institutionalised adults living in Ohio who have had at least one TBI with LOC were more likely to report fair or poor health, more days of poor health, more days when poor health limited activities, being diagnosed with a chronic condition and having less than 7 hours of sleep per night. The relationship with increasing number of TBIs was monotonic, with the likelihood of adverse health increasing as the number increased. A similar relationship was observed for increasing severity of the worst lifetime TBI. Experiencing a first TBI before age 15 was associated with poorer health but was not statistically different than incurring a first after age 15.ConclusionsAdults who have experienced TBI with LOC in their lifetime are two to three times more likely to experience adverse health conditions when compared with same age-matched, sex-matched and race-matched adults without such history. These findings support re-examining the public health burden of TBI in light of lifetime exposure and not just the consequences of an index injury.

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Opioid Drug Utilization and Cost Outcomes Associated With the Use of Buprenorphine-Naloxone in Patients With a History of Prescription Opioid Use

Journal of Managed Care Pharmacy ◽

10.18553/jmcp.2008.14.2.186 ◽

2008 ◽

Vol 14 (2) ◽

pp. 186-194 ◽

Cited By ~ 6

Author(s):

Aman Deep Kaur ◽

Angela McQueen ◽

Saira Jan

Keyword(s):

Drug Utilization ◽

Prescription Opioid ◽

Opioid Use ◽

History Of ◽

Prescription Opioid Use ◽

Cost Outcomes

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Lifetime history of traumatic brain injury among persons with substance use disorders

Brain Injury ◽

10.3109/02699052.2011.648705 ◽

2012 ◽

Vol 26 (2) ◽

pp. 139-150 ◽

Cited By ~ 54

Author(s):

John D. Corrigan ◽

Jennifer Bogner ◽

Christopher Holloman

Keyword(s):

Traumatic Brain Injury ◽

Substance Use ◽

Brain Injury ◽

Substance Use Disorders ◽

Lifetime History ◽

History Of

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O3-11-04: ASSOCIATIONS BETWEEN LIFETIME HISTORY OF TRAUMATIC BRAIN INJURY AND DEMENTIA-RELATED NEUROPATHOLOGICAL FINDINGS AT AUTOPSY: THE ADULT CHANGES IN THOUGHT STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2014.04.332 ◽

2014 ◽

Vol 10 ◽

pp. P231-P232

Author(s):

Christopher Dirk Keene ◽

Laura E. Gibbons ◽

Joshua Sonnen ◽

Kristen Dams-O'Connor ◽

Rod Walker ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Lifetime History ◽

History Of

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Cerebrospinal Fluid MicroRNA Changes in Cognitively Normal Veterans With a History of Deployment-Associated Mild Traumatic Brain Injury

Frontiers in Neuroscience ◽

10.3389/fnins.2021.720778 ◽

2021 ◽

Vol 15 ◽

Author(s):

Theresa A. Lusardi ◽

Ursula S. Sandau ◽

Nikita A. Sakhanenko ◽

Sarah Catherine B. Baker ◽

Jack T. Wiedrick ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Cerebrospinal Fluid ◽

Brain Injury ◽

Significant Differential Expression ◽

Cognitively Normal ◽

Lifetime History ◽

Increased Risk ◽

History Of ◽

Community Controls ◽

Group Comparisons

A history of traumatic brain injury (TBI) increases the odds of developing Alzheimer’s disease (AD). The long latent period between injury and dementia makes it difficult to study molecular changes initiated by TBI that may increase the risk of developing AD. MicroRNA (miRNA) levels are altered in TBI at acute times post-injury (<4 weeks), and in AD. We hypothesized that miRNA levels in cerebrospinal fluid (CSF) following TBI in veterans may be indicative of increased risk for developing AD. Our population of interest is cognitively normal veterans with a history of one or more mild TBI (mTBI) at a chronic time following TBI. We measured miRNA levels in CSF from three groups of participants: (1) community controls with no lifetime history of TBI (ComC); (2) deployed Iraq/Afghanistan veterans with no lifetime history of TBI (DepC), and (3) deployed Iraq/Afghanistan veterans with a history of repetitive blast mTBI (DepTBI). CSF samples were collected at the baseline visit in a longitudinal, multimodal assessment of Gulf War veterans, and represent a heterogenous group of male veterans and community controls. The average time since the last blast mTBI experienced was 4.7 ± 2.2 years [1.5 – 11.5]. Statistical analysis of TaqManTM miRNA array data revealed 18 miRNAs with significant differential expression in the group comparisons: 10 between DepTBI and ComC, 7 between DepC and ComC, and 8 between DepTBI and DepC. We also identified 8 miRNAs with significant differential detection in the group comparisons: 5 in DepTBI vs. ComC, 3 in DepC vs. ComC, and 2 in DepTBI vs. DepC. When we applied our previously developed multivariable dependence analysis, we found 13 miRNAs (6 of which are altered in levels or detection) that show dependencies with participant phenotypes, e.g., ApoE. Target prediction and pathway analysis with miRNAs differentially expressed in DepTBI vs. either DepC or ComC identified canonical pathways highly relevant to TBI including senescence and ephrin receptor signaling, respectively. This study shows that both TBI and deployment result in persistent changes in CSF miRNA levels that are relevant to known miRNA-mediated AD pathology, and which may reflect early events in AD.

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