EVALUATING CONTRAST SENSITIVITY IN AGE-RELATED MACULAR DEGENERATION USING A NOVEL COMPUTER-BASED TEST, THE SPAETH/RICHMAN CONTRAST SENSITIVITY TEST

This article provides an unsystematic literature review devoted to analyzing the currently existing methods of functional diagnostics for age-related macular degeneration.The essence, advantages and disadvantages, and literature data on the use of such methods asphotostresstest, electrooculography, dark adaptation study, contrast sensitivity function assessment, light and color sensitivity study,electroretinographyand critical flicker fusion frequencyare described.Based on the analysis of literature data, itis shownthat currently, there is a need to searchfor informative and accessible methods of functional diagnostics in age-related macular degeneration, especially for its early diagnosis. The analysis has shown that the existing methods are mainly aimed either at fixing secondary morphological changes in the layer of pigment epithelial cells, at identifying the pathology of the pigment epithelium in conjunction with determining the function of photoreceptor elements, or at a comprehensive assessment of the structures of several layers of the retina. Keywords:age-related macular degeneration; methods of functional diagnostics; photostress test; electrooculography; contrast sensitivity

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Computer-based detection of age-related macular degeneration and glaucoma using retinal images and clinical data

Medical Imaging 2019: Computer-Aided Diagnosis ◽

10.1117/12.2513009 ◽

2019 ◽

Author(s):

Vinayak Joshi ◽

Jeffrey Wigdahl ◽

Jeremy Benson ◽

Sheila Nemeth ◽

Peter Soliz

Keyword(s):

Macular Degeneration ◽

Clinical Data ◽

Age Related Macular Degeneration ◽

Retinal Images ◽

Age Related ◽

Computer Based

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Multifocal intraocular lenses and retinal diseases

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-020-04603-0 ◽

2020 ◽

Vol 258 (4) ◽

pp. 805-813 ◽

Cited By ~ 1

Author(s):

Andrzej Grzybowski ◽

Piotr Kanclerz ◽

Raimo Tuuminen

Keyword(s):

Diabetic Retinopathy ◽

Macular Degeneration ◽

Contrast Sensitivity ◽

Intraocular Lenses ◽

Age Related Macular Degeneration ◽

Visual Field Defects ◽

Retinal Diseases ◽

Epiretinal Membranes ◽

Multifocal Intraocular Lenses ◽

Age Related

Abstract Purpose Multifocal intraocular lenses (MIOLs) are often discouraged in patients with or at risk of retinal disorders (including diabetic retinopathy, age-related macular degeneration, and epiretinal membranes), as MIOLs are believed to reduce contrast sensitivity (CS). Concerns with MIOLs have also been raised in individuals with visual field defects, fixation instability or eccentric preferred retinal locations. The aim of this study is to review the influence of MIOL on quality of vision in patients with retinal diseases. Methods We reviewed the PubMed and Web of Science databases to identify relevant studies using the following keywords: multifocal intraocular lens, cataract surgery, cataract extraction, lens exchange, diabetic retinopathy, age-related macular degeneration, and contrast sensitivity. Results Studies evaluating CS in MIOLs present conflicting results: MIOLs either did not influence CS or resulted in worse performance under low-illuminance conditions and higher spatial frequencies when compared to monofocal IOLs. Nevertheless, MIOLs preserved CS levels within the age-matched normal range. Two studies reported that patients with concurrent retinal diseases receiving a MIOL, both unilaterally and bilaterally, reported a significant improvement in visual-related outcomes. Individuals with a monofocal IOL in one eye and a MIOL in the fellow eye reported greater subjective satisfaction with the MIOL. Conclusion We were unable to find evidence suggesting that patients with retinal diseases should be advised against MIOLs. Nevertheless, more research is needed to address the aforementioned concerns and to optimize the use of MIOLs in eyes with retinal disease.

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Contrast Sensitivity in Age-Related Macular Degeneration

Archives of Ophthalmology ◽

10.1001/archopht.1988.01060130061028 ◽

1988 ◽

Vol 106 (1) ◽

pp. 55-57 ◽

Cited By ~ 70

Author(s):

R. C. Kleiner ◽

C. Enger ◽

M. F. Alexander ◽

S. L. Fine

Keyword(s):

Macular Degeneration ◽

Contrast Sensitivity ◽

Age Related Macular Degeneration ◽

Age Related

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Colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration

European Journal of Ophthalmology ◽

10.1177/1120672119866386 ◽

2019 ◽

Vol 30 (6) ◽

pp. 1487-1494

Author(s):

Antonio Calcagni ◽

Olivia Howells ◽

Frank Eperjesi ◽

Hannah Bartlett ◽

Alastair KO Denniston ◽

...

Keyword(s):

High Risk ◽

Macular Degeneration ◽

Contrast Sensitivity ◽

Age Related Macular Degeneration ◽

Reference Database ◽

Colour Contrast ◽

Age Related ◽

Quality Of Vision ◽

Prospective Longitudinal

Purpose: To generate the first published reference database of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration and to explore this important feature in quality of vision. Background: Quality of vision depends on many factors. Changes in chromatic contrast sensitivity remain largely unexplored in eyes at high risk of neovascular age-related macular degeneration; they may however not only be relevant for quality of life but also an early indicator of the onset of the disease, so it is important to have a means to evaluate any variation in colour contrast sensitivity, especially in view of the likely increase in neovascular age-related macular degeneration as the population ages. Methods: This prospective longitudinal study evaluated colour contrast sensitivity along the protan and tritan colour axes in 145 eyes at high risk of neovascular age-related macular degeneration. Results: Colour contrast sensitivity showed statistically significant correlations with age and visual acuity, but not gender nor laterality (i.e. whether the right or left eye was being tested). There was significant variability among individuals, especially for the tritan axis, with some subjects well within normal limits for age and others with very poor colour contrast sensitivity. Conclusion: This study has generated the first published colour contrast sensitivity reference database for eyes at high risk of neovascular age-related macular degeneration. It has also shown a high inter-individual variability of colour contrast sensitivity in eyes at high risk of neovascular age-related macular degeneration, but the significance of this is unclear. Further work is required to establish if eyes with high colour contrast sensitivity thresholds (i.e. poor colour vision) have a higher risk of developing neovascular age-related macular degeneration over time, and this is the subject of ongoing work.

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