MULTIMODAL IMAGING OF EARLY STAGE 1 TYPE 3 NEOVASCULARIZATION WITH SIMULTANEOUS EYE-TRACKED SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY AND HIGH-SPEED REAL-TIME ANGIOGRAPHY

A 76-year-old male presented with a small hyperreflective density in the outer nuclear layer with subtle retinal pigment epithelium (RPE) elevation and few intraretinal cysts on spectral-domain optical coherence tomography (SD-OCT). Optical coherence tomography angiography (OCTA) confirmed the presence of a tuft-shaped intraretinal neovascular lesion. SD-OCT performed 2 months before showed a smaller RPE elevation at the same location without intraretinal fluid. A 79-year-old male presented with a small hyperreflective density in the outer retina surrounded by scant intraretinal fluid on SD-OCT and a bright vessel on OCTA, suggesting early-stage type 3 neovascularization. SD-OCT performed 2 months before showed a smaller hyperreflectivity at the same location, without intraretinal fluid. An 84-year-old female presented with hyperreflective foci in the outer retina overlying a serous pigment epithelium detachment (PED) with focal RPE disruption on SD-OCT. SD-OCT performed 2 months before showed the same hyperreflective lesion associated with a shallower PED. No neovascular lesions were found on OCTA after six injections of bevacizumab. To conclude, careful evaluation of SD-OCT allows for early detection of type 3 neovascularization at a pre-exudative stage. OCTA may be useful in confirming the presence of intraretinal neovascular lesion and monitoring response to anti-vascular endothelial growth factor agents.

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AN UPDATED STAGING SYSTEM OF TYPE 3 NEOVASCULARIZATION USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

Retina ◽

10.1097/iae.0000000000001268 ◽

2016 ◽

Vol 36 ◽

pp. S40-S49 ◽

Cited By ~ 38

Author(s):

Daniel Su ◽

Shawn Lin ◽

Nopasak Phasukkijwatana ◽

Xuejing Chen ◽

Anna Tan ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Staging System ◽

Spectral Domain ◽

Optical Coherence ◽

Type 3 Neovascularization ◽

Type 3

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Graphics processing unit aided highly stable real-time spectral-domain optical coherence tomography at 1375 nm based on dual-coupled-line subtraction

Laser Physics Letters ◽

10.1088/1612-2011/10/4/045604 ◽

2013 ◽

Vol 10 (4) ◽

pp. 045604 ◽

Cited By ~ 8

Author(s):

Ji-hyun Kim ◽

Jae-Ho Han ◽

Jichai Jeong

Keyword(s):

Optical Coherence Tomography ◽

Real Time ◽

Graphics Processing Unit ◽

Spectral Domain ◽

Processing Unit ◽

Optical Coherence ◽

Coupled Line ◽

Graphics Processing

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The role of quantitative deep capillary plexus in the pathogenesis of type 3 macular neovascularization: an optical coherence tomography angiography study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-021-05330-w ◽

2021 ◽

Author(s):

Marina Concilio ◽

Federica Fossataro ◽

Daniela Montorio ◽

Mariapaola Giordano ◽

Gilda Cennamo

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Early Stage ◽

Study Groups ◽

Control Group ◽

Main Role ◽

Optical Coherence ◽

Capillary Plexus ◽

Type 3

Abstract Purpose To quantitatively investigate the role of deep capillary plexus (DCP) in patients affected by type 3 macular neovascularization (MNV), compared to patients with reticular pseudodrusen (RPD) eyes and healthy controls, using optical coherence tomography angiography (OCTA). Methods In this prospective observational study, a total of seventy-eight eyes of 78 patients were included. Group 1 consisted of 40 eyes of 40 patients with stage 1 of type 3 MNV (22 males, 18 females, mean age 73.7, SD ± 6.60) and group 2 included 38 eyes of 38 patients with RPD (17 males, 21 females, mean age 73.2, SD ± 4.55). The control group included 40 eyes of 40 healthy subjects (20 males, 20 females, mean age 71.4, SD ± 6.36 years). We evaluated the retinal vessel density (VD) of superficial capillary plexus (SCP) and deep capillary plexus (DCP) using OCTA. Results Patients with diagnosis of type 3 MNV showed statistically lower values of VD in DCP with respect to controls and to RPD group (p < 0.001), while there were no statistical differences between RPD and control group in macular region. No significant differences in VD of SCP were detected among the three study groups. Conclusion OCTA provides a reproducible, non-invasive detailed quantitative analysis of retinal vascular features and changing in early-stage type 3 MNV patients, which allowed to shed the light on the main role of DCP ischemia in the development of type 3 MNV.

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