High Frequency of Bone Marrow Depression During Congenital Toxoplasmosis Therapy in a Cohort of Children Identified by Neonatal Screening in Minas Gerais, Brazil

SummaryThe clinical course and the haematologic events in a patient suffering from metastatic thyroid cancer after administration of 806 mCi of 131I are described. A serious bone marrow depression developed and was treated successfully. The haematological changes during the early and late phases of the radiation injury were studied in detail and compared with those after external irradiation. The haematological events after internal irradiation with 131I are characterised by initial neutrophilic leukocytosis, protracted lymphopenia, slowly developing anaemia reaching lowest values about 3 months after administration, erythroid hyperplasia in the bone marrow after recovery from bone marrow depression and prominent cytological features of the bone marrow, especially pronounced erythropoietic polyploidy.

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Low magnitude high frequency vibrations expedite the osteogenesis of bone marrow stem cells on paper based 3D scaffolds

Biomedical Engineering Letters ◽

10.1007/s13534-020-00161-w ◽

2020 ◽

Vol 10 (3) ◽

pp. 431-441 ◽

Cited By ~ 2

Author(s):

Ozge Karadas ◽

Gulistan Mese ◽

Engin Ozcivici

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

High Frequency ◽

Bone Marrow Stem Cells ◽

3D Scaffolds ◽

High Frequency Vibrations ◽

Low Magnitude

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Adverse Socioeconomic Conditions and Oocyst-Related Factors Are Associated with Congenital Toxoplasmosis in a Population-Based Study in Minas Gerais, Brazil

PLoS ONE ◽

10.1371/journal.pone.0088588 ◽

2014 ◽

Vol 9 (2) ◽

pp. e88588 ◽

Cited By ~ 13

Author(s):

Ericka Viana Machado Carellos ◽

Gláucia Manzan Queiroz de Andrade ◽

Daniel Vitor Vasconcelos-Santos ◽

José Nélio Januário ◽

Roberta Maia Castro Romanelli ◽

...

Keyword(s):

Congenital Toxoplasmosis ◽

Population Based ◽

Minas Gerais ◽

Socioeconomic Conditions ◽

Related Factors ◽

Population Based Study

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Allopurinol and cytotoxic drugs. Interaction in relation to bone marrow depression. Boston Collaborative Drug Surveillance Program

JAMA ◽

10.1001/jama.227.9.1036 ◽

1974 ◽

Vol 227 (9) ◽

pp. 1036-1040 ◽

Cited By ~ 6

Keyword(s):

Bone Marrow ◽

Cytotoxic Drugs ◽

Surveillance Program ◽

Drug Surveillance ◽

Bone Marrow Depression ◽

Drugs Interaction

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Acute monoblastic leukemia: a clinical and biologic study of 74 cases

Blood ◽

10.1182/blood.v55.1.71.71 ◽

1980 ◽

Vol 55 (1) ◽

pp. 71-76 ◽

Cited By ~ 96

Author(s):

G Tobelem ◽

C Jacquillat ◽

C Chastang ◽

MF Auclerc ◽

T Lechevallier ◽

...

Keyword(s):

Bone Marrow ◽

High Frequency ◽

Poor Prognosis ◽

Remission Rate ◽

Blast Cell ◽

Saint Louis ◽

Coagulation Abnormalities ◽

Acute Monoblastic Leukemia ◽

Fab Classification ◽

Urine Levels

Abstract Seventy-four cases of pure acute monoblastic leukemia (AMol) have been retrospectively studied. All patients were treated at Hospital Saint- Louis between 1970 and 1978. Diagnosis was based on morphological and cytochemical features according to the FAB classification. This type of leukemia occurred at any age and in both sexes, with a high frequency of extramedullary involvements. Hyperleukocytosis was very frequent and was significantly correlated with increased blood and urine levels of lysozyme, with renal failure and hypokalemia, and with coagulation abnormalities. AMol still has a poor prognosis, despite a best remission rate (75%) obtained with rubidazone, since the duration of complete remission was short. Central nervous irradiation prolonged remission and prevented meningeal relapses, while 6 meningeal relapses occurred in the patients not irradiated. The high frequency of the extramedullary relapses, including gum and skin, emphasized the question of persistant blast cell sanctuaries after achievement of bone marrow remissions. A more intensive induction with several drugs active against monoblasts could be more efficient and prolong the duration of complete remissions.

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