MP05-07 THE PROFILE STUDY—TARGETED SCREENING USING GERMLINE GENETICS IN MEN WITH A FAMILY HISTORY OF PROSTATE CANCER: THE ROLE OF MULTIPARAMETRIC MRI

Abstract Can divide-and-rule colonial policy be responsible for contemporary ethnic tension? This paper empirically investigates the role of a divisive and extractive colonial policy on Hutu-Tutsi discord in Rwanda and Burundi. It shows that Hutu with a family history of subjugation to forced labour by Tutsi chiefs are less trusting of Tutsi today and less willing to partner with Tutsi for a cooperative task. This may have implications for agriculture insurance agreements since Hutu are more agrarian and Tutsi are more pastoral. Indeed, Hutu with a forced labour family history make fewer inter-household insurance agreements and are more likely to experience default.

Download Full-text

CHEK2∗1100delC Mutation and Risk of Prostate Cancer

Prostate Cancer ◽

10.1155/2014/294575 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 24

Author(s):

Victoria Hale ◽

Maren Weischer ◽

Jong Y. Park

Keyword(s):

Prostate Cancer ◽

Current Knowledge ◽

Prostate Cancer Screening ◽

Critical Role ◽

Prostate Cancer Risk ◽

Conclusive Evidence ◽

Increased Risk ◽

History Of ◽

Cancer Studies

Although the causes of prostate cancer are largely unknown, previous studies support the role of genetic factors in the development of prostate cancer.CHEK2plays a critical role in DNA replication by responding to double-stranded breaks. In this review, we provide an overview of the current knowledge of the role of a genetic variant, 1100delC, ofCHEK2on prostate cancer risk and discuss the implication for potential translation of this knowledge into clinical practice. Currently, twelve articles that discussedCHEK2∗1100delC and its association with prostate cancer were identified. Of the twelve prostate cancer studies, five studies had independent data to draw conclusive evidence from. The pooled results of OR and 95% CI were 1.98 (1.23–3.18) for unselected cases and 3.39 (1.78–6.47) for familial cases, indicating thatCHEK2∗1100delC mutation is associated with increased risk of prostate cancer. Screening for CHEK2∗1100delC should be considered in men with a familial history of prostate cancer.

Download Full-text

T2044 Family History of Pancreas, Breast, Colon, Bladder, and Prostate Cancer in Patients with Pancreas Cancer Supports a Syndromic Predisposition

Gastroenterology ◽

10.1016/s0016-5085(08)62834-6 ◽

2008 ◽

Vol 134 (4) ◽

pp. A-607

Author(s):

Aimee L. Lucas ◽

Aliye Z. Bill ◽

Caroline Hwang ◽

Elizabeth Verna ◽

Nicole Goetz ◽

...

Keyword(s):

Prostate Cancer ◽

Family History ◽

Pancreas Cancer ◽

History Of

Download Full-text

The role of family history of diabetes as a predictor of insulin activity in a sample of diverse, normal weight children

Endocrine and Metabolic Science ◽

10.1016/j.endmts.2021.100090 ◽

2021 ◽

Vol 3 ◽

pp. 100090

Author(s):

Jessica J. Denton ◽

Jose R. Fernandez

Keyword(s):

Family History ◽

Normal Weight ◽

Family History Of Diabetes ◽

History Of ◽

Insulin Activity

Download Full-text

Sex Differences in Inmates: Anger, Sensitivity to Provocation and Family History of Imprisonment

International Journal of Offender Therapy and Comparative Criminology ◽

10.1177/0306624x211049189 ◽

2021 ◽

pp. 0306624X2110491

Author(s):

Marta Bodecka-Zych ◽

Anna Zajenkowska ◽

Mary Bower Russa

Keyword(s):

Family History ◽

Comparison Group ◽

Female Inmates ◽

Male And Female ◽

Female Prisoners ◽

Increased Risk ◽

Incarcerated Populations ◽

History Of ◽

Male Prisoners

Little research has explored the role of aggression, anger, and family history of incarceration as they relate to female offenders. The current study aimed to address this gap in the literature by investigating these possible risk factors for incarceration among both men and women. The survey involved 123 (61 female and 62 male) prisoners convicted for violent crimes and a comparison group of 118 (60 female and 58 male) adults from the community. We found that women (convicted and non-convicted) were more sensitive to provocation than men, while community adults showed higher levels of trait anger than prisoners. Detainees were more likely than community adults to have a relative in prison. Although male and female inmates were equally likely to have a relative in prison, they differed in their relation to the imprisoned relative. Male and female prisoners showed increased risk for incarceration of same sex, first degree relatives (father and brothers for men, and mothers for women). These results may contribute to improved understanding of incarcerated populations. As such, this represents a critical first step in creating recovery programs that are more gender appropriate.

Download Full-text