PD45-09 OPTIMIZATION OF KIDNEY DECELLULARIZATION METHODS UTILIZING A QUANTITATIVE VASCULAR CASTING TECHNIQUE FOR LONG-TERM IMPLANTATION

This research aimed to developintrapocket,biodegradablechips ofpoly(d,l-lactide-co-glycolide) (PLGA) loaded with Metronidazole (MZ) and levofloxacin (LF),for sustained release local drug delivery in periodontal pocket to treat periodontitis. Metronidazole and levofloxacin are widely employed for the treatment of periodontitis,but high oral dose and resistance development after long-term oral administration limit their use, hence local delivery is a good approach. The chips were prepared by solvent casting technique using diethyl phthalate as plasticizer. Their physical characteristics, such as drug content,surface pH, swelling index, and folding endurance, exhibited results within limit. Further, FTIR and DSCstudies revealed stability of chips and compatibility between drugs and excipients.In vitro release in McIlvainebuffer pH 7.8 was of sustained nature assisted by the burst effect. Design-Expert® (11.0.4) software was used to study the effect of polymer & plasticizer on release of drugs Polymer concentrationsnegatively affected drug release and positively affected T90 (time for releasing 90% of the drug) due toaltered matrix density. In contrast, the plasticizer concentration increases membrane permeability andhence increased drug release, lowering T90. Forvarious response variables,polynomial mathematical models were generated usingmultiple regression analysis, and found to be statistically significant (????<0.05).The antibacterial efficacy of films was tested on Pseudomonas spp. Bacteroides spp., indicatinggood antibacterial activity. Optimized formulations were further used for preparing optimized biodegradable, Metronidazole-Levofloxacin sustained release chip. Conclusively, the films of MZ and LF were successful tools for the management ofperiodontitis.

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The Use of Laser-welded Titanium Framework Technology: A Case Report for the Totally Edentulous Patient

Journal of Oral Implantology ◽

10.1563/779.1 ◽

2005 ◽

Vol 31 (6) ◽

pp. 294-300 ◽

Cited By ~ 4

Author(s):

Brian J. Jackson

Keyword(s):

Edentulous Patient ◽

Endosseous Implants ◽

Casting Technique ◽

Dental Practitioners ◽

Framework Technology ◽

Widespread Acceptance ◽

Fabrication Procedure ◽

Implant Dentistry ◽

Long Term Studies

Abstract Laser-welded technology has become a viable alternative to the conventional lost wax-casting technique in the field of implant dentistry. Studies have demonstrated the predictable nature of laser-welded titanium frameworks for endosseous implants in the partial and totally edentulous patient. A standardized impression and fabrication procedure is required for an accurate and predictable superstructure. More long-term studies are needed for more widespread acceptance and usage by dental practitioners.

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Construction and functional assessment of zein thin film incorporating spindle-like ZnO crystals

RSC Advances ◽

10.1039/c6ra25290g ◽

2017 ◽

Vol 7 (4) ◽

pp. 2180-2185 ◽

Cited By ~ 9

Author(s):

Ying Cao ◽

Ting-Ting Chen ◽

Wei Wang ◽

Meng Chen ◽

Hua-Jie Wang

Keyword(s):

Thin Film ◽

Functional Assessment ◽

Antibacterial Activities ◽

Solution Casting ◽

Casting Technique ◽

Solution Casting Technique

Zein thin film incorporating spindle-like ZnO crystals could be prepared by a solution-casting technique. The active films exhibited well stability and long-term antibacterial activities, which were related with the loaded ZnO crystals.

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Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine Dihydrochloride/Poly(lactic-co-glycolic acid)

BioMed Research International ◽

10.1155/2015/836939 ◽

2015 ◽

Vol 2015 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Zhiqiang Xu ◽

Yingzhen Lai ◽

Dong Wu ◽

Wenxiu Huang ◽

Sijia Huang ◽

...

Keyword(s):

Glycolic Acid ◽

Drug Carrier ◽

Titania Nanotubes ◽

Electrochemical Anodization ◽

Sustained Drug Release ◽

Casting Technique ◽

Antibacterial Ability ◽

Octenidine Dihydrochloride ◽

Marrow Mesenchymal Stem Cells

Titanium (Ti) implants with long-term antibacterial ability and good biocompatibility are highly desirable materials that can be used to prevent implant-associated infections. In this study, titania nanotubes (TNTs) were synthesized on Ti surfaces through electrochemical anodization. Octenidine dihydrochloride (OCT)/poly(lactic-co-glycolic acid) (PLGA) was infiltrated into TNTs using a simple solvent-casting technique. OCT/PLGA-TNTs demonstrated sustained drug release and maintained the characteristic hollow structures of TNTs. TNTs (200 nm in diameter) alone exhibited slight antibacterial effect and good osteogenic activity but also evidently impaired adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs). OCT/PLGA-TNTs (100 nm in diameter) supported BMSC adhesion and proliferation and showed good osteogenesis-inducing ability. OCT/PLGA-TNTs also exhibited good long-term antibacterial ability within the observation period of 7 d. The synthesized drug carrier with relatively long-term antibacterial ability and enhanced excellent biocompatibility demonstrated significant potential in bone implant applications.

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A long-term study of early fluid therapy in severely burned adults. 3. Simultaneous comparison of saline solution alone or combined with plasma

JAMA ◽

10.1001/jama.195.4.268 ◽

1966 ◽

Vol 195 (4) ◽

pp. 268-274 ◽

Cited By ~ 4

Author(s):

M. Bocanegra

Keyword(s):

Fluid Therapy ◽

Saline Solution ◽

Term Study ◽

Long Term Study ◽

Simultaneous Comparison ◽

Early Fluid

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Therapy and prevention for mental health: What if mental diseases are mostly not brain disorders?

Behavioral and Brain Sciences ◽

10.1017/s0140525x1800105x ◽

2019 ◽

Vol 42 ◽

Cited By ~ 2

Author(s):

John P. A. Ioannidis

Keyword(s):

Mental Health ◽

Mental Disease ◽

Brain Disorders ◽

Social Stressors ◽

Labor Education ◽

Mental Diseases ◽

Long Term Follow Up ◽

Political Decisions

AbstractNeurobiology-based interventions for mental diseases and searches for useful biomarkers of treatment response have largely failed. Clinical trials should assess interventions related to environmental and social stressors, with long-term follow-up; social rather than biological endpoints; personalized outcomes; and suitable cluster, adaptive, and n-of-1 designs. Labor, education, financial, and other social/political decisions should be evaluated for their impacts on mental disease.

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Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

Behavioral and Brain Sciences ◽

10.1017/s0140525x15000928 ◽

2016 ◽

Vol 39 ◽

Author(s):

Mary C. Potter

Keyword(s):

Working Memory ◽

Rapid Serial Visual Presentation ◽

Language Comprehension ◽

Short Term Memory ◽

Visual Presentation ◽

Long Term Memory ◽

Short Term ◽

Term Memory ◽

Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

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Brief summary of Kleť photographic search programme for minor planets

International Astronomical Union Colloquium ◽

10.1017/s0252921100031419 ◽

1999 ◽

Vol 173 ◽

pp. 189-192

Author(s):

J. Tichá ◽

M. Tichý ◽

Z. Moravec

Keyword(s):

Ccd Camera ◽

Minor Planet ◽

Minor Planets ◽

Main Belt

AbstractA long-term photographic search programme for minor planets was begun at the Kleť Observatory at the end of seventies using a 0.63-m Maksutov telescope, but with insufficient respect for long-arc follow-up astrometry. More than two thousand provisional designations were given to new Kleť discoveries. Since 1993 targeted follow-up astrometry of Kleť candidates has been performed with a 0.57-m reflector equipped with a CCD camera, and reliable orbits for many previous Kleť discoveries have been determined. The photographic programme results in more than 350 numbered minor planets credited to Kleť, one of the world's most prolific discovery sites. Nearly 50 per cent of them were numbered as a consequence of CCD follow-up observations since 1994.This brief summary describes the results of this Kleť photographic minor planet survey between 1977 and 1996. The majority of the Kleť photographic discoveries are main belt asteroids, but two Amor type asteroids and one Trojan have been found.

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