scholarly journals Antibacterial Effects and Biocompatibility of Titania Nanotubes with Octenidine Dihydrochloride/Poly(lactic-co-glycolic acid)

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Zhiqiang Xu ◽  
Yingzhen Lai ◽  
Dong Wu ◽  
Wenxiu Huang ◽  
Sijia Huang ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Drug Carrier ◽  
Titania Nanotubes ◽  
Electrochemical Anodization ◽  
Sustained Drug Release ◽  
Casting Technique ◽  
Antibacterial Ability ◽  
Octenidine Dihydrochloride ◽  
Marrow Mesenchymal Stem Cells

Titanium (Ti) implants with long-term antibacterial ability and good biocompatibility are highly desirable materials that can be used to prevent implant-associated infections. In this study, titania nanotubes (TNTs) were synthesized on Ti surfaces through electrochemical anodization. Octenidine dihydrochloride (OCT)/poly(lactic-co-glycolic acid) (PLGA) was infiltrated into TNTs using a simple solvent-casting technique. OCT/PLGA-TNTs demonstrated sustained drug release and maintained the characteristic hollow structures of TNTs. TNTs (200 nm in diameter) alone exhibited slight antibacterial effect and good osteogenic activity but also evidently impaired adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs). OCT/PLGA-TNTs (100 nm in diameter) supported BMSC adhesion and proliferation and showed good osteogenesis-inducing ability. OCT/PLGA-TNTs also exhibited good long-term antibacterial ability within the observation period of 7 d. The synthesized drug carrier with relatively long-term antibacterial ability and enhanced excellent biocompatibility demonstrated significant potential in bone implant applications.

Polydopamine-induced nanocomposite Ag/CaP coatings on the surface of titania nanotubes for antibacterial and osteointegration functions

2015 ◽  
Vol 3 (45) ◽  
pp. 8796-8805 ◽  
Author(s):  
Ming Li ◽  
Qian Liu ◽  
Zhaojun Jia ◽  
Xuchen Xu ◽  
Yuying Shi ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Composite Coating ◽  
Titania Nanotubes ◽  
Nano Silver ◽  
Antibacterial Ability ◽  
Biological Performance

A mussel-inspired novel nano silver/calcium phosphate (CaP) composite coating was prepared on anodized Ti, with its surface maintaining preferable biological performance and possessing long-term antibacterial ability.

scholarly journals Increased Mesenchymal Stem Cell Response and DecreasedStaphylococcus aureusAdhesion on Titania Nanotubes without Pharmaceuticals

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Zhiqiang Xu ◽  
Yingzhen Lai ◽  
Dong Wu ◽  
Wenxiu Huang ◽  
Sijia Huang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Response ◽  
Bacterial Adhesion ◽  
Orthopedic Implants ◽  
Titania Nanotubes ◽  
Electrochemical Anodization ◽  
Success Rates ◽  
Marrow Mesenchymal Stem Cells ◽  
Cell Adhesion And Proliferation

Titanium (Ti) implants with enhanced biocompatibility and antibacterial property are highly desirable and characterized by improved success rates. In this study, titania nanotubes (TNTs) with various tube diameters were fabricated on Ti surfaces through electrochemical anodization at 10, 30, and 60 V (denoted as NT10, NT30, and NT60, resp.). Ti was also investigated and used as a control. NT10 with a diameter of 30 nm could promote the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs) without noticeable differentiation. NT30 with a diameter of 100 nm could support the adhesion and proliferation of BMSCs and induce osteogenesis. NT60 with a diameter of 200 nm demonstrated the best ability to promote cell spreading and osteogenic differentiation; however, it clearly impaired cell adhesion and proliferation. As the tube diameter increased, bacterial adhesion on the TNTs decreased and reached the lowest value on NT60. Therefore, NT30 without pharmaceuticals could be used to increase mesenchymal stem cell response and decreaseStaphylococcus aureusadhesion and thus should be further studied for improving the efficacy of Ti-based orthopedic implants.

Nanostructured Lipid Carriers (NLCs) for drug delivery: Role of Liquid lipid (oil)

2020 ◽  
Vol 17 ◽  
Author(s):  
Anisha D’Souza ◽  
Ranjita Shegokar
Keyword(s):  
Drug Delivery ◽  
Essential Oils ◽  
Drug Carrier ◽  
Drug Loading ◽  
Performance Criteria ◽  
Long Term Stability ◽  
Natural Oils ◽  
Optimal Drug

: In recent years, SLNs and NLCs are among the popular drug delivery systems studied for delivery of lipophilic drugs. Both systems have demonstrated several beneficial properties as an ideal drug-carrier, optimal drug-loading and good long-term stability. NLCs are getting popular due to their stability advantages and possibility to load various oil components either as an active or as a matrix. This review screens types of oils used till date in combination with solid lipid to form NLCs. These oils are broadly classified in two categories: Natural oils and Essential oils. NLCs offer range advantages in drug delivery due to the formation of imperfect matrix owing to the presence of oil. The type and percentage of oil used determines optimal drug loading and stability. Literature shows that variety of oils is used in NLCs mainly as matrix, which is from natural origin, triglycerides class. On the other hand, essential oils not only serve as a matrix but as an active. In short, oil is the key ingredient in formation of NLCs, hence needs to be selected wisely as per the performance criteria expected.

Stereocomplexation Assisted Assembly of Poly(γ-glutamic Acid)-graft-polylactide Nano-micelles and Their Efficacy as Anticancer Drug Carrier

2018 ◽  
Vol 18 (2) ◽  
pp. 302-311
Author(s):  
Shulin Dai ◽  
Yucheng Feng ◽  
Shuyi Li ◽  
Yuxiao Chen ◽  
Meiqing Liu ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Drug Carriers ◽  
Cancer Drug ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
Anti Cancer ◽  
Physical Interactions

Background: Micelles as drug carriers are characterized by their inherent instability due to the weak physical interactions that facilitate the self-assembly of amphiphilic block copolymers. As one of the strong physical interactions, the stereocomplexation between the equal molar of enantiomeric polylactides, i.e., the poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA), may be harnessed to obtain micelles with enhanced stability and drug loading capacity and consequent sustained release. </P><P> Aims/Methods: In this paper, stereocomplexed micelles gama-PGA-g-PLA micelles) were fabricated from the stereocomplexation between poly(gama-glutamic acid)-graft-PLLA gama-PGA-g-PLA) and poly(gamaglutamic acid)-graft-PDLA gama-PGA-g-PLA). These stereocomplexed micelles exhibited a lower CMC than the corresponding enantiomeric micelles. Result: Furthermore, they showed higher drug loading content and drug loading efficiency in addition to more sustained drug release profile in vitro. In vivo imaging confirmed that the DiR-encapsulated stereocomplexed gama-PGA-g-PLA micelles can deliver anti-cancer drug to tumors with enhanced tissue penetration. Overall, gama-PGA-g-PLA micelles exhibited greater anti-cancer effects as compared with the free drug and the stereocomplexation may be a promising strategy for fabrication of anti-cancer drug carriers with significantly enhanced efficacy.

scholarly journals Extracellular Vesicles: “Stealth Transport Aircrafts” for Drugs

2020 ◽  
Author(s):  
Chunying Liu ◽  
Xuejing Lin ◽  
Changqing Su
Keyword(s):  
Extracellular Vesicles ◽  
Drug Carrier ◽  
Drug Loading ◽  
Source Material ◽  
Material Transport ◽  
Disease Treatment ◽  
Small Molecule Drugs ◽  
Viral Particles ◽  
The Stability

Extracellular vesicles (EVs) can deliver many types of drugs with their natural source material transport properties, inherent long-term blood circulation capabilities and excellent biocompatibility, and have great potential in the field of drug carrier. Modification of the content and surface of EVs according to the purpose of treatment has become a research focus to improve the drug load and the targeting of EVs. EVs can maximize the stability of the drugs, prevent immune clearance and achieve accurate delivery. Therefore, EVs can be described as \" stealth transport aircrafts \" for drugs. This chapter will respectively introduce the application of natural EVs as cell substitutes in cell therapy and engineered EVs as carriers of nucleic acids, proteins, small molecule drugs and therapeutic viral particles in disease treatment. It will also explain the drug loading and modification strategies of EVs, the source and characteristics of EVs. In addition, the commercialization progress of EVs drugs will be mentioned here, and the problems in their applications will be discussed in conjunction with the application of EVs in the treatment of COVID-19.

Fabrication and characterization of highly-ordered titania nanotubes via electrochemical anodization

2008 ◽  
Vol 62 (17-18) ◽  
pp. 2688-2691 ◽  
Author(s):  
Ruixia Ge ◽  
Wuyou Fu ◽  
Haibin Yang ◽  
Yanyan Zhang ◽  
Wenyan Zhao ◽  
...  
Keyword(s):  
Titania Nanotubes ◽  
Electrochemical Anodization ◽  
Fabrication And Characterization

Engineering microenvironment of biodegradable polyester systems for drug stability and release control

2021 ◽  
Author(s):  
Nisar Ul Khaliq ◽  
Dhawal Chobisa ◽  
Coralie A Richard ◽  
Monica R Swinney ◽  
Yoon Yeo
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Release Kinetics ◽  
Drug Stability ◽  
Poly Lactic Acid ◽  
Polymeric Systems ◽  
Us Fda ◽  
History Of Use ◽  
Release Control

Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.

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