Comparison of serum levels of inflammatory markers and allelic variant of interleukin-6 in patients with acute coronary syndrome and stable angina pectoris

2008 ◽  
Vol 19 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Oznur Ozdemir ◽  
Fuat Gundogdu ◽  
Sule Karakelleoglu ◽  
Serdar Sevimli ◽  
Ibrahim Pirim ◽  
...  
2013 ◽  
Vol 36 (4) ◽  
pp. 234 ◽  
Author(s):  
Cong-Lin Liu ◽  
De-Liang Shen ◽  
Kui Zhu ◽  
Jun-Nan Tang ◽  
Qi-Min Hai ◽  
...  

Purpose: The purpose of this study was to investigate the levels of interleukin-33 (IL-33) and interleukin-6 (IL-6) in patients with acute coronary syndrome or stable angina. Methods: Serum IL-33 and IL-6 were measured with Enzyme Linked Immuosorbent Assay (ELISA) in patients with acute coronary syndrome (ACS, n = 40), and stable angina pectoris (SAP, n = 43). IL-33 and IL-6 were also determined in 30 healthy subjects (control group). Results: The serum level of IL-33 in the ACS group (78.60 ± 44.84 ng/L) was lower than in the SAP (102.58 ± 37.21 ng/L, P < 0.01) or control groups (130.24 ± 10.17 ng/L, P < 0.01). The serum level of IL-6 in the ACS group (39.90 ± 12.64 ng/L) was higher than in the SAP (18.68 ± 11.89 ng/L, P < 0.05) or control groups (6.28 ± 17.72 ng/L, P < 0.05). There were no differences in serum levels of IL-33 and IL-6 among the single-, double- and triple-vessel lesion groups. IL-33 and IL-6 levels were negatively correlated with each other in the ACS (r = -0.871, P < 0.01) and SAP groups (r = -0.788, P < 0.01). Conclusion: The serum level of IL-33 was lower in patients with ACS or SAP and was negatively correlated with the serum level of IL-6. Thus, IL-33 and IL-6 may be used as biomarkers for evaluating inflammatory response and severity of coronary heart disease in patients with ACS or SAP.


2011 ◽  
Vol 75 (2) ◽  
pp. 383-390 ◽  
Author(s):  
Hirohiko Ando ◽  
Tetsuya Amano ◽  
Tatsuaki Matsubara ◽  
Tadayuki Uetani ◽  
Michio Nanki ◽  
...  

2010 ◽  
Vol 55 (3) ◽  
pp. 345-353 ◽  
Author(s):  
Hidenori Yagi ◽  
Kimiaki Komukai ◽  
Koichi Hashimoto ◽  
Makoto Kawai ◽  
Takayuki Ogawa ◽  
...  

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