First Case Report of a Sporadic Adrenocortical Carcinoma With Gastric Metastasis and a Synchronous Gastrointestinal Stromal Tumor of the Stomach

Abstract Gastrointestinal stromal tumor is a rare neoplasm affecting gastrointestinal tract. Duodenal gastrointestinal stromal tumor originating from the fourth segment is considered an extremely rare disease. Surgical challenges arise when managing locally recurrent hemorrhagic duodenal gastrointestinal stromal tumor. A 58-year-old male presented with melena for the last 10 days. Thirty months previously, he had segmental resection of the fourth duodenal portion due to hemorrhagic gastrointestinal stromal tumor. No adjuvant imatinib therapy was administered (low risk for recurrence). The latest investigations showed actively bleeding tumor in the distal third portion of the duodenum, indicating a locally recurrent gastrointestinal stromal tumor. Uneventful emergent limited resection was performed. To the best of our knowledge, this is the first case report describing locally recurrent gastrointestinal stromal tumor in the distal duodenal portion. We will explain the therapeutic challenges and risk stratification and discuss gastrointestinal bleeding as a prognostic indicator for gastrointestinal stromal tumor recurrence.

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Coexistence of gastrointestinal stromal tumor and inflammatory myofibroblastic tumor of the stomach presenting as a collision tumor: first case report and literature review

Diagnostic Pathology ◽

10.1186/s13000-015-0413-y ◽

2015 ◽

Vol 10 (1) ◽

Cited By ~ 4

Author(s):

Hyeong Chan Shin ◽

Mi Jin Gu ◽

Se Won Kim ◽

Jae Woon Kim ◽

Joon Hyuk Choi

Keyword(s):

Case Report ◽

Literature Review ◽

Gastrointestinal Stromal Tumor ◽

Inflammatory Myofibroblastic Tumor ◽

Collision Tumor ◽

Stromal Tumor ◽

First Case

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Non-Exposed Endoscopic Wall-Inversion Surgery for Gastrointestinal Stromal Tumor of the Stomach: First Case Report in Korea

Clinical Endoscopy ◽

10.5946/ce.2016.002 ◽

2016 ◽

Vol 49 (5) ◽

pp. 475-478 ◽

Cited By ~ 3

Author(s):

Da Won Kim ◽

Joon Sung Kim ◽

Byung-Wook Kim ◽

Ji Yun Jung ◽

Gi Jun Kim ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Stromal Tumor ◽

Stromal Tumor ◽

First Case

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Extraintestinal gastrointestinal stromal tumor of undetermined origin: Is the mass resection a wrong approach? A case report and review of the literature

Archivio Italiano di Urologia e Andrologia ◽

10.4081/aiua.2015.2.177 ◽

2015 ◽

Vol 87 (2) ◽

pp. 177

Author(s):

Özgür Haki Yüksel ◽

Serkan Akan ◽

Çaglar Yildirim ◽

Ahmet Ürkmez ◽

Ayhan Verit

Keyword(s):

Case Report ◽

Gastrointestinal Stromal Tumor ◽

Radical Surgery ◽

Disease Recurrence ◽

Gastrointestinal System ◽

Stromal Tumor ◽

Review Of The Literature ◽

First Case ◽

Radiological Methods

Gastrointestinal stromal tumor (GIST) was first defined by Mazur et al. in 1983. GIST is evaluated among tumoral lesions that can be acquired or congenital. Those not associated with gastrointestinal system are termed as extragastrointestinal stromal tumor (EGIST). EGISTs can develop on intraperitoneal spaces as omentum, mesenterium and gallbladder and they can occur on retroperitoneum, extraperitoneal (prostate) and intrapelvic organs. Herein, we present a case with EGIST in a 65-year-old male patient located in intrapelvic and retroprostatic area which had no connection with gastrointestinal system as assessed by radiological methods and we discuss its treatment. We reviewed the literature and observed that ours is the first case report on a patient in which the mass was only extirpated rather than performing radical surgery. He is still at the 2. year of his follow-up period without any disease recurrence.

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Tumor Lysis Syndrome in Gastrointestinal Stromal Tumor Treated with the Oral Tyrosine Kinase Inhibitor Imatinib: A Case Report

Journal of Gastroenterology Research ◽

10.36959/621/589 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

Yuan Jeng-Nian ◽

Li Anna Fen-Yau ◽

Chen Chih-Yen

Keyword(s):

Case Report ◽

Tyrosine Kinase ◽

Gastrointestinal Stromal Tumor ◽

Tyrosine Kinase Inhibitor ◽

Kinase Inhibitor ◽

Tumor Lysis Syndrome ◽

Stromal Tumor ◽

Tumor Lysis

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ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation:a case report

Diagnostic Pathology ◽

10.1186/s13000-020-0926-x ◽

2020 ◽

Vol 15 (1) ◽

Cited By ~ 2

Author(s):

Jun Fan ◽

Ming Yang ◽

Bo Huang ◽

Zhenkao Wang ◽

Danju Luo ◽

...

Keyword(s):

Case Report ◽

Gastrointestinal Stromal Tumor ◽

Stromal Tumor

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Preoperatively diagnosed gastric collision tumor with mixed adenocarcinoma and gastrointestinal stromal tumor: a case report and literature review

Clinical Journal of Gastroenterology ◽

10.1007/s12328-021-01343-4 ◽

2021 ◽

Author(s):

Kunihiko Matsuno ◽

Yoshikazu Kanazawa ◽

Daisuke Kakinuma ◽

Nobutoshi Hagiwara ◽

Fumihiko Ando ◽

...

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Distal Gastrectomy ◽

Submucosal Tumor ◽

Smooth Muscle Actin ◽

Collision Tumor ◽

Stromal Tumor ◽

Lower Body ◽

Muscle Actin ◽

First Case ◽

S 100

AbstractReports of gastric collision tumors, comprising adenocarcinoma and gastrointestinal stromal tumor, are extremely rare. Here, we report the case of a 68-year-old male who was diagnosed with a lower-body, moderately differentiated, tubular-type adenocarcinoma and submucosal tumor and underwent an elective D2 distal gastrectomy. The tumor cells of the gastrointestinal stromal tumor were positive for H-caldesmon and CD117, weakly positive for smooth muscle actin and DOG-1, and negative for desmin, S-100 protein, CD31, and AE1/AE3. The tumor had grown into a mixed form of adenocarcinoma and gastrointestinal stromal tumor. Thus, we report the first case of a preoperatively diagnosed collision tumor in the stomach consisting of adenocarcinoma and gastrointestinal stromal tumor.

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