scholarly journals Assessing Region of Interest Schemes for the Corticospinal Tract in Patients With Brain Tumors

Medicine ◽  
2016 ◽  
Vol 95 (12) ◽  
pp. e3189 ◽  
Author(s):  
Chen Niu ◽  
Xin Liu ◽  
Yong Yang ◽  
Kun Zhang ◽  
Zhigang Min ◽  
...  
2011 ◽  
Vol 31 (7) ◽  
pp. 1623-1636 ◽  
Author(s):  
Eugene Kim ◽  
Jiangyang Zhang ◽  
Karen Hong ◽  
Nicole E Benoit ◽  
Arvind P Pathak

Abnormal vascular phenotypes have been implicated in neuropathologies ranging from Alzheimer's disease to brain tumors. The development of transgenic mouse models of such diseases has created a crucial need for characterizing the murine neurovasculature. Although histologic techniques are excellent for imaging the microvasculature at submicron resolutions, they offer only limited coverage. It is also challenging to reconstruct the three-dimensional (3D) vasculature and other structures, such as white matter tracts, after tissue sectioning. Here, we describe a novel method for 3D whole-brain mapping of the murine vasculature using magnetic resonance microscopy (μMRI), and its application to a preclinical brain tumor model. The 3D vascular architecture was characterized by six morphologic parameters: vessel length, vessel radius, microvessel density, length per unit volume, fractional blood volume, and tortuosity. Region-of-interest analysis showed significant differences in the vascular phenotype between the tumor and the contralateral brain, as well as between postinoculation day 12 and day 17 tumors. These results unequivocally show the feasibility of using μMRI to characterize the vascular phenotype of brain tumors. Finally, we show that combining these vascular data with coregistered images acquired with diffusion-weighted MRI provides a new tool for investigating the relationship between angiogenesis and concomitant changes in the brain tumor microenvironment.


2020 ◽  
Author(s):  
T. Szmuda ◽  
S. Kierońska ◽  
S. Ali ◽  
P. Słoniewski ◽  
M. Pacholski ◽  
...  

1992 ◽  
Vol 77 (1) ◽  
pp. 151-154 ◽  
Author(s):  
Duc H. Duong ◽  
Robert C. Rostomily ◽  
David R. Haynor ◽  
G. Evren Keles ◽  
Mitchel S. Berger

✓ The authors describe a method for quantitation of the area and volume of the resection cavity in patients who have undergone surgery for brain tumors. Using a slide scanner and Image 1.27, a public domain program for the Apple Macintosh II computer, computerized tomography scans and magnetic resonance images can be digitized and analyzed for a particular region of interest, such as the area and volume of tumor on preoperative and postresection scans. Phantom scans were used to analyze the accuracy of the program and the program users. User error was estimated at 2%, program error was 4.5%. This methodology is proposed as a means of retrospectively calculating the extent of tumor resection.


Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1856
Author(s):  
Marriam Nawaz ◽  
Tahira Nazir ◽  
Momina Masood ◽  
Awais Mehmood ◽  
Rabbia Mahum ◽  
...  

The brain tumor is a deadly disease that is caused by the abnormal growth of brain cells, which affects the human blood cells and nerves. Timely and precise detection of brain tumors is an important task to avoid complex and painful treatment procedures, as it can assist doctors in surgical planning. Manual brain tumor detection is a time-consuming activity and highly dependent on the availability of area experts. Therefore, it is a need of the hour to design accurate automated systems for the detection and classification of various types of brain tumors. However, the exact localization and categorization of brain tumors is a challenging job due to extensive variations in their size, position, and structure. To deal with the challenges, we have presented a novel approach, namely, DenseNet-41-based CornerNet framework. The proposed solution comprises three steps. Initially, we develop annotations to locate the exact region of interest. In the second step, a custom CornerNet with DenseNet-41 as a base network is introduced to extract the deep features from the suspected samples. In the last step, the one-stage detector CornerNet is employed to locate and classify several brain tumors. To evaluate the proposed method, we have utilized two databases, namely, the Figshare and Brain MRI datasets, and attained an average accuracy of 98.8% and 98.5%, respectively. Both qualitative and quantitative analysis show that our approach is more proficient and consistent with detecting and classifying various types of brain tumors than other latest techniques.


Neurosurgery ◽  
2013 ◽  
Vol 60 ◽  
pp. 169
Author(s):  
Andreas Raabe ◽  
Jürgen Beck ◽  
Philippe Schucht ◽  
Kathleen Seidel

2014 ◽  
Vol 121 (2) ◽  
pp. 349-358 ◽  
Author(s):  
Maria Luisa Mandelli ◽  
Mitchel S. Berger ◽  
Monica Bucci ◽  
Jeffrey I. Berman ◽  
Bagrat Amirbekian ◽  
...  

Object The aim of this paper was to validate the diffusion tensor imaging (DTI) model for delineation of the corticospinal tract using cortical and subcortical white matter electrical stimulation for the location of functional motor pathways. Methods The authors compare probabilistic versus deterministic DTI fiber tracking by reconstructing the pyramidal fiber tracts on preoperatively acquired DTI in patients with brain tumors. They determined the accuracy and precision of these 2 methods using subcortical stimulation points and the sensitivity using cortical stimulation points. The authors further explored the reliability of these methods by estimation of the potential that the found connections were due to a random chance using a novel neighborhood permutation method. Results The probabilistic tracking method delineated tracts that were significantly closer to the stimulation points and was more sensitive than deterministic DTI fiber tracking to define the tracts directed to the motor sites. However, both techniques demonstrated poor sensitivity to finding lateral motor regions. Conclusions This study highlights the importance of the validation and quantification of preoperative fiber tracking with the aid of electrophysiological data during the surgery. The poor sensitivity of DTI to delineate lateral motor pathways reported herein suggests that DTI fiber tracking must be used with caution and only as adjunctive data to established methods for motor mapping.


2017 ◽  
Vol 18 (5) ◽  
pp. 844 ◽  
Author(s):  
Zhi-gang Min ◽  
Chen Niu ◽  
Qiu-li Zhang ◽  
Ming Zhang ◽  
Yu-cheng Qian

2013 ◽  
Vol 3 ◽  
pp. 361-368 ◽  
Author(s):  
Monica Bucci ◽  
Maria Luisa Mandelli ◽  
Jeffrey I. Berman ◽  
Bagrat Amirbekian ◽  
Christopher Nguyen ◽  
...  

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