Aberrant long-range functional connectivity density in generalized tonic-clonic seizures

Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. Methods: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China. Here, we examined BQD individuals (n = 33) and age-, sex-, and education-matched healthy controls (HCs) (n = 32) in a rs-fMRI study to observe FCD alterations associated with the severity of BQD. Results: Compared with HCs, long-range FCD was decreased in the right anterior cingulate cortex (ACC) and increased in the left cerebellum posterior lobe (CPL) and bilateral inferior parietal lobule (IPL) in the BQD group. Short-range FCD was reduced in the right ACC and left dorsolateral prefrontal cortex (dlPFC), and increased in the left CPL. The short-range FCD alteration in the right ACC displayed a negative correlation with the Betel Quid Dependence Scale (BQDS) (r=-0.432, P=0.012), and the long-range FCD alteration of left IPL showed a positive correlation with the duration of BQD(r=0.519, P=0.002) in BQD individuals. Conclusions: fMRI revealed differences in long- and short- range FCD in BQD individuals, and these alterations might be due to BQ chewing, BQ dependency, or risk factors for developing BQD.

Download Full-text

Aberrant Resting-State Functional Connectivity Density in Patients with Hepatitis B Virus-Related Cirrhosis

BioMed Research International ◽

10.1155/2016/4168512 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Xiao-Fei Lv ◽

Hua-Wang Wu ◽

Li Tian ◽

Lu-Jun Han ◽

Jing Li ◽

...

Keyword(s):

Hepatic Encephalopathy ◽

Hepatitis B Virus ◽

Functional Connectivity ◽

Hepatitis B ◽

Long Range ◽

Resting State ◽

Short Range ◽

Resting State Functional Connectivity ◽

Functional Connectivity Density ◽

B Virus

There is increasing evidence that cirrhosis may affect functional connectivity among various brain regions in patients prior to onset of overt hepatic encephalopathy (HE). However, most investigators have focused mainly on alterations in functional connectivity strengths, and the changes in functional connectivity density (FCD) are largely unknown. Here, we investigated alterations in resting-state FCD in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt HE. Totally, 31 patients with HBV-RC without overt HE and 30 age- and sex-matched healthy controls underwent resting-state functional MRI examinations. FCD mapping was employed to compute local and global FCD maps. Then, short-range and long-range FCD values were calculated and voxel-based comparisons were performed between the two groups. The HBV-RC group showed significant decreases in FCD, including decreased short-range FCDs in the bilateral middle cingulum gyrus/precuneus, the bilateral cuneus, and the left lingual gyrus/inferior occipital gyrus and decreased long-range FCD in the bilateral cuneus/precuneus. In addition, the decreased long-range FCD in the bilateral cuneus/precuneus in the HBV-RC group was related to performance on the psychometric hepatic encephalopathy score (PHES) test. These findings suggest aberrant functional connectivity density in cirrhotic patients prior to overt HE onset, which may provide better insight into understanding the pathophysiological mechanisms underlying the cirrhotic-related cognitive impairment.

Download Full-text

Short- and long-range functional connectivity density alterations in adolescents with pure conduct disorder at resting-state

Neuroscience ◽

10.1016/j.neuroscience.2017.03.040 ◽

2017 ◽

Vol 351 ◽

pp. 96-107 ◽

Cited By ~ 19

Author(s):

Feng-Mei Lu ◽

Jian-Song Zhou ◽

Xiao-Ping Wang ◽

Yu-Tao Xiang ◽

Zhen Yuan

Keyword(s):

Functional Connectivity ◽

Conduct Disorder ◽

Long Range ◽

Resting State ◽

Functional Connectivity Density

Download Full-text

Resting-State Long-Range Functional Connectivity Density Reveals Sensorimotor Rhythm-Based BCI Performance Variations

Advances in Cognitive Neurodynamics (V) - Advances in Cognitive Neurodynamics ◽

10.1007/978-981-10-0207-6_54 ◽

2016 ◽

pp. 391-396

Author(s):

Rui Zhang ◽

Tao Zhang ◽

Teng Ma ◽

Fali Li ◽

Dezhong Yao ◽

...

Keyword(s):

Functional Connectivity ◽

Long Range ◽

Resting State ◽

Functional Connectivity Density ◽

Sensorimotor Rhythm ◽

Performance Variations

Download Full-text

Abnormal white matter functional connectivity density in antipsychotic-naive adolescents with schizophrenia

Clinical Neurophysiology ◽

10.1016/j.clinph.2020.12.031 ◽

2021 ◽

Vol 132 (5) ◽

pp. 1025-1032

Author(s):

Xiao Wang ◽

Wei Liao ◽

Shaoqiang Han ◽

Fengmei Lu ◽

Zongling He ◽

...

Keyword(s):

White Matter ◽

Functional Connectivity ◽

Functional Connectivity Density

Download Full-text

Association Between Brain Activation and Functional Connectivity

Cerebral Cortex ◽

10.1093/cercor/bhy077 ◽

2018 ◽

Vol 29 (5) ◽

pp. 1984-1996 ◽

Cited By ~ 13

Author(s):

Dardo Tomasi ◽

Nora D Volkow

Keyword(s):

Functional Connectivity ◽

Brain Activity ◽

Low Frequency ◽

Brain Activation ◽

Blood Oxygen Level Dependent ◽

Common Source ◽

Functional Connectivity Density ◽

Density Mapping ◽

Human Connectome Project ◽

Bold Responses

Abstract The origin of the “resting-state” brain activity recorded with functional magnetic resonance imaging (fMRI) is still uncertain. Here we provide evidence for the neurovascular origins of the amplitude of the low-frequency fluctuations (ALFF) and the local functional connectivity density (lFCD) by comparing them with task-induced blood-oxygen level dependent (BOLD) responses, which are considered a proxy for neuronal activation. Using fMRI data for 2 different tasks (Relational and Social) collected by the Human Connectome Project in 426 healthy adults, we show that ALFF and lFCD have linear associations with the BOLD response. This association was significantly attenuated by a novel task signal regression (TSR) procedure, indicating that task performance enhances lFCD and ALFF in activated regions. We also show that lFCD predicts BOLD activation patterns, as was recently shown for other functional connectivity metrics, which corroborates that resting functional connectivity architecture impacts brain activation responses. Thus, our findings indicate a common source for BOLD responses, ALFF and lFCD, which is consistent with the neurovascular origin of local hemodynamic synchrony presumably reflecting coordinated fluctuations in neuronal activity. This study also supports the development of task-evoked functional connectivity density mapping.

Download Full-text