The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis

Background. Helicobacter pylori is an important carcinogenic factor in gastric cancer. Studies have shown that Helicobacter pylori infection is inversely associated with certain diseases such as esophageal cancer and whose infection appears to have a “protective effect.” At present, the relationship between Helicobacter pylori infection and esophageal cancer remains controversial. This study was designed to investigate the relationship between Helicobacter pylori infection and the risk of esophageal cancer in different regions and ethnicities. Methods. Systematic search of the articles on the relationship between Helicobacter pylori infection and esophageal cancer from the database with the duration time up to December 2018. This systematic review was performed under the MOOSE guidelines. Results. This meta-analysis included 35 studies with 345,886 patients enrolled. There was no significant correlation between Helicobacter pylori infection and esophageal squamous cell carcinoma in the general population (OR: 0.84; 95% CI: 0.64-1.09/OR: 0.74; 95% CI: 0.54-0.97). However, a significant correlation was found in the Middle East (OR: 0.34; 95% CI: 0.22-0.52/95% CI: 0.26-0.44). There was no significant difference in the prevalence of Helicobacter pylori between the case group and the control group in esophageal adenocarcinoma (8.87% vs. 9.67%). The pooled OR was 0.55 (95% CI: 0.43-0.70) or 0.23 (95% CI: 0.15-0.36). When grouped by match or not, the pooled OR of the nonmatching group and the matching group was 0.48/0.21 (95% CI: 0.36-0.65/95% CI: 0.13-0.36) and 0.73/0.71 (95% CI: 0.57-0.92/95% CI: 0.60-0.84), respectively. Conclusion. In the general populations, no significant association was found between Helicobacter pylori infection and the risk of esophageal squamous cell carcinoma. However, lower risk was found in the Middle East. Helicobacter pylori infection may reduce the risk of esophageal adenocarcinoma, but such “protection effect” may be overestimated.

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Gastric-juice ammonia assay for diagnosis of Helicobacter pylori infection and the relationship of ammonia concentration to gastritis severity

The American Journal of Gastroenterology ◽

10.1111/j.1572-0241.2000.03351.x ◽

2000 ◽

Vol 95 (12) ◽

pp. 3399-3403 ◽

Cited By ~ 13

Author(s):

David J. Kearney ◽

Kindred Ritchie ◽

Jeffrey S. Peacock

Keyword(s):

Helicobacter Pylori ◽

Gastric Juice ◽

Ammonia Concentration ◽

Helicobacter Pylori Infection ◽

Relationship Of ◽

The Relationship

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Sex differences in the relationship among alcohol, smoking, and Helicobacter pylori infection in asymptomatic individuals

Journal of International Medical Research ◽

10.1177/0300060520926036 ◽

2020 ◽

Vol 48 (5) ◽

pp. 030006052092603

Author(s):

Wenzhi Wu ◽

Marcis Leja ◽

Vladislav Tsukanov ◽

Zarrin Basharat ◽

Dong Hua ◽

...

Keyword(s):

Helicobacter Pylori ◽

Logistic Regression ◽

Regression Analysis ◽

Alcohol Consumption ◽

Logistic Regression Analysis ◽

Helicobacter Pylori Infection ◽

Multivariable Logistic Regression Analysis ◽

H Pylori ◽

Relationship Of ◽

The Relationship

Objective We aimed to investigate the relationship of Helicobacter pylori infection with alcohol and smoking. Methods We conducted a cross-sectional study among participants who underwent health check-ups for H. pylori infection between January 2013 and March 2017. We subsequently investigated the relationship of H. pylori infection with alcohol and smoking. Results A total of 7169 participants were enrolled in this study. The overall prevalence of H. pylori infection was 55.2%. Participants with H. pylori infection were more likely to be older than those without H. pylori infection. For male participants with H. pylori infection, multivariable logistic regression analysis indicated that both smoking (odds ratio (OR): 1.61; 95% confidence interval (CI): 1.41–1.83) and alcohol consumption (OR: 1.30; 95% CI: 1.10–1.52) were independently positively associated with H. pylori infection. For female participants, multivariable logistic regression analysis indicated that both smoking (OR: 0.03; 95% CI: 0.02–0.07) and alcohol consumption (OR: 0.20; 95% CI: 0.12–0.33) were inversely significantly associated with H. pylori infection after adjustment for age. Conclusions Smoking and alcohol consumption were risk factors for male participants but these were protective factors for female individuals with H. pylori infection.

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Helicobacter Pylori is the Cause of Gastric Cancer

Modern Health Science ◽

10.30560/mhs.v1n1p43 ◽

2018 ◽

Vol 1 (1) ◽

pp. p43

Author(s):

Ilija Barukcic

Keyword(s):

Gastric Cancer ◽

Helicobacter Pylori ◽

Causal Relationship ◽

Null Hypothesis ◽

Meta Analysis ◽

Helicobacter Pylori Infection ◽

Human Gastric Cancer ◽

Mathematical Formula ◽

The Relationship

Objective: This study presents a systematic meta-analysis of the relationship between Helicobacter pylori (HP) infection and gastric cancer (GC). Materials and Methods: Twelve articles including 21589 subjects were selected (1237 cases and 20352 controls). These data were analyzed using the mathematical formula of the conditio sine qua non relationship and the causal relationship formula. Results: The data re-analyzed support the Null hypothesis without a Helicobacter pylori infection no human gastric cancer. The causal relationship between HP and GC is highly significant. Conclusion: Helicobacter pylori is the cause of human gastric cancer.

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