Nanone interactions in antibody of living systems

One of the facts about how nanoparticle assemble and act is revealed using carbon value in biomolecule of living system here. This is how the biomolecules interact to bring about a micro or even macro level interaction in system of interest. This study shows micro level understanding can be better utilized from carbon analysis at nano level. I plan to extend this phenomena of change from nano to micro for building large scale applications in human nature. Applications include corrections in both at sequence and structure level for permanent recovery of defective one, adding flavor to the existing biomolecule for faster delivery or recovery etc. I have demonstrated here the active role played by carbon and all. This might be extended to another system of setup where new applications yet to be created. One can extend this phenomena of change from nano to large scale one.

Impact of Socio-Demographic Characteristics on the Pattern of Skin Diseases Attending Different Dermatology Department of Public Hospitals Quetta, Pakistan

Objective: The study was conducted to determine the pattern of skin diseases affecting by the socio-demographic characteristics of the patients visiting the dermatology department of public hospitals in Quetta, Pakistan. Methodology: The prospective cross-sectional study was undertaken using a self prepapred proforma to compile the data while interviewing the patients attending the Dermatology Department of two public hospitals of Quetta, Pakistan, in order to determine the relationship between the demographic characteristics of patients and pattern of skin diseases. Results: A total of 503 patients were enrolled in the study. Majority of the participants (33.8%) were categorized in the age group of 21-30 years. The most common patterns of skin diseases seen in outpatient department were eczema (21.5%), scabies (19.7%) and bacterial infections (12.7%). Inferential statistics revealed a significant relationship (p=0.001) between pattern of skin diseases and age, education, house occupancy, location and living standards of the study participants. Most of the patients were found to be living in a combined family system (65.6%), with poor living standards (81.7%) and uneducated (51.1%). Conclusion The current study presented that eczema and infectious diseases were the most common pattern of skin diseases in Quetta and they are significantly related with socio-demographics of the patients so it can be concluded that better health education, maintaining personal hygiene, and improvement in the standard of living may aid a lot in managing and preventing the common skin diseases.

The Impact of Antihypertensive Agents on Health-Related Quality of Life of Hypertensive Patients

Chronic diseases and their treatment regimen plays a greater role in determining the patient related health outcomes of which one is Health Related Quality of Life. Hypertension itself along with its pharmacotherapy impacts HRQoL of hypertensive patients. The primary objective of the study was to determine the impact of f hypertensive medications on the health-related quality of life among hypertensive patients with the secondary objective to assess which medication significantly affects health related quality of life of hypertensive patients. A quantitative questionnaire based cross-sectional survey was undertaken in outpatient departments of Sandeman Provisional Hospital (SPH) Quetta using an EQ-5D-3L to determine the Health-Related Quality of Life. Convenience Sampling technique was used for data collection. Majority of respondents (8.7%) had no problem in first three domains while having some problem in pain and anxiety domains. Following them 7.6% of patients had some problems in all domains of the EQ5D tool. Moreover. the ACE Inhibitors and Diuretics impacts HRQoL of patients of current study. A total of 263 participated in the study of which (25%) of the respondents were of age group 48 -75 years old and were married 73.4% mostly. Majority (8.7%) had no problem in first three domains while having some problem in pain and anxiety domains. ACE Inhibitors and Diuretics significantly influence the health status of hypertensive patients acquiring pharmacotherapy. It was concluded that antihypertensive agents have a significant impact on HRQoL of hypertensive patients especially Angiotensin Converting Enzymes and Diuretics, which show significant impact on HRQoL of hypertensive patients. However, it is also suggested to assess the impact of antihypertensive therapies given in combination must also be studied in order to provide health professionals a better understanding of their prescribed regimen to improve patient related health outcomes.

Attitudes of Primary Pregnant Women Toward Preference of Birth Method in Dezful, Iran: A Cross-Sectional Study

Introduction: Choosing the birth method is a major issue for pregnant women that is affected by multifaceted physiological, psychological and socio-cultural factors. Aim(s): The aim research was performed to explore factors influencing pregnant women’s attitude toward birth method. Methods: This is a cross-sectional study on 220 healthy nulliparous pregnant women with uncomplicated pregnancies without any contraindication for vaginal birth in Medical Centers of Dezful, in the south west of Iran. Data collection tool was a questionnaire for factors affecting the choice of delivery method. Differences in attitude were compared between two groups of natural vaginal delivery preference and cesarean delivery preference. Statistical analysis was performed with SPSS Version 16.0 statistic software package. Descriptive statistics were used to report percentages, mean, and standard deviation, and t-test, chi-square were applied to analyze the data. Results: During the study period, 206 primary pregnant women were examined to determine the attitudinal influencing factors the birth method preference. 131 women (64%) chose the natural delivery method and 71 women (36%) chose the cesarean delivery method. In addition, the results showed a statistically significant difference between the two groups regarding the general attitude of the participants towards natural delivery (164.43 in the normal vaginal delivery (NVD) group versus 134.50 in the cesarean section (CS) group (p < 0.001)). Conclusion: There is a direct relationship between the attitude of pregnant women towards vaginal birth and the tendency to normal vaginal delivery and cesarean section. Also, according to the results of the study of 8 components of attitudes, counseling sessions and prenatal training sessions can be identified based on counseling needs and be guided counseling sessions more purposefully.

Corneal Distortion and Corneal Morphological Parameters in Naïve Eyes Analyzed with a Scheimpflug Camera

Background: The study of the corneal biomechanical properties (CBP) is gaining always more interest, thanks to the applications to refractive surgery and to the overall management of several corneal diseases. Purpose: To analyze the eventual relationships between corneal distortion and morphologic features in healthy subjects. Methods: one eye of one hundred and fifty-two healthy participants, 87 women and 65 men, aging from 23 to 65 years old, were evaluated in this study. Every eye underwent a complete clinical examination, that included also a tomographic scan using Pentacam HR (Oculus, Wetzlar, Germany) and a biomechanical evaluation using Corvis ST (Oculus, Wetzlar, Germany). Linear regressions among refractive defect, corneal volume (CV), anterior corneal curvature and central corneal thickness (CCT) vs corneal biomechanical features provided by Corvis ST have been ran using SPSS software version 18.0. Results: Corneal distortion factors showed a low correlation both with corneal morphological parameters and with refractive defect. No significant correlations (p> 0.01) were found among morphologic and biomechanical features evaluated. Discussion: results observed in this study could help in recognize the healthy range of values of CBP parameters provided by CST. This information could be very useful in many ophthalmology topics such as the accurate IOP measurement, the early diagnosis of corneal degenerations, such as keratoconous, and the screening of subject undergoing refractive surgery. Conclusions: even if data of this study need to be confirmed in further ones with larger populations, results here observed suggest that Corvis ST is a device providing an evaluation of corneal distortion not influenced by morphological corneal factors. This information could help in better screening and managing the diseased corneas.

Formulation and Quality Optimization of Effervescent Tablet of Glipizide: An Approach to Comfort Anti-Diabetic Medication

The present study is targeted to formulate and prepare effervescent tablets of Glipizide to provide more elegancy, comfortability, and improved pharmacokinetics in diabetic treatment than the conventional dosage. Three formulations (F1, F2, and F3) of the effervescent tablet of Glipizide (5mg) were formulated with different amounts and ratios of excipients. By wet granulation technique, 60 tablets for every formulation were prepared with a weight of 700mg per tablet. Then, the features of both granules and tablets were evaluated by published methods. The angle of repose, Hausner ratio, Carr's index, Loss on drying (LOD), and Moisture Content (MC) used to measure granules property successfully proved right follow ability and compressibility. In contrast, physical and drug content related investigation failed to determine the perfectness of all three formulations. Friability on the formulations was around 0.70%, indicating the expected USP limit of friability (0.5 to 1%). The mean disintegration time of the formulations was from 95s to 105s. The tablet potency assay found 95.20% for F1, 88.80% for F2, and 97.40% for F3. The dissolution pattern of the drug followed a linear relationship with time. After one and a half hours, the highest amount of 59.20% cumulative dissolution was determined for F3 that revealed its strategic improvement of the drug solubility. As Glipizide is a poorly water-soluble drug, the effervescent tablet might mitigate disintegration and dissolution-related limitations and, consequently, enhance the drug's bioavailability.

Evaluation of Corneal Reflectance in Sjögren's Syndrome Dry Eye

Introduction: To measure corneal layers’ light reflectance (LR) in eyes affected by dry eye disease caused by Sjögren's syndrome (SSDE) with corneal confocal microscopy (IVCM) and to study the correlations with tear film tests. Materials and Methods: Thirty-six patients affected by SSDE and 36 healthy subjects (HS) were enrolled in this retrospective study, participants of both groups were age and sex matched. Each study participants had a complete eye visit and break up time (BUT), Schirmer test, with and without stimulation, at the end of the visit an IVCM scan was performed. LR measured by IVCM at Bowman membrane (BM) level and at 50 µm, at 100 µm and at 200 µm deeper was compared in the two groups of participants. The correlations between LR measurements and tear film test results were investigated. Results: In SSDE eyes, LR was significantly higher (p<0.001) in SSDE patients at BM level (+14.43 ± 3.27 LRU) and also in the other levels evaluated, compared with HP. Good correlations were observed between LR values at BM and Schirmer test ones with (r = -0.82) and without (r= -0.81) stimulation and BUT (r= 0.80) in SSDE eyes. Correlations values were Adecreasing the deeper corneal layers. Conclusion: Even if need to be verified in further studies with a larger population, results obtained in this study suggest that IVCM could be an interesting and effective tool in evaluating the SSDE patients and it could be adopted by physicians’ community because it seems very promising.

Application of Dose Area Product (DAP) to Estimate Entrance Surface Dose (ESD) in Pediatric Chest X-Rays

Introduction: Given the high radiation tissue sensitivity of pediatric patients, it is necessary to monitor their received dose to optimize radiation protection. The first aim of this study was to evaluate the entrance surface dose (ESD) in pediatric patients undergoing a chest X-ray at the main hospital of Dezful, Iran. The second aim was to compare our results with the established dose reference levels (DRLs). Materials and Methods: The studied population included 204 pediatric patients less than 15 years who were referred to as chest X-ray. A calibrated dose area product meter (DAP-meter) with permanent installation on the X-ray unit was used to radiation dose measurements. For each patient, the demographic data, exposure parameters and the dose read by DAP-meter were recorded and ESD was calculated using a standard mathematical formula. Results: The average value of ESD was 119 μGy in patients less than 15 years. This value was 51.3, 122.3, 131.5 and 171.2 μGy for the age groups for less than 1 year, 1 to 5 years, 5 to 10 years and 10 to 15 years, respectively. A statistically significant difference was seen between ESD values ​​in different age groups (P<0.001), whereas no statistical difference was seen between ESD values in ​ girls and boys (P =0.993). Conclusion: Pediatric patients in hospital investigated (except age group less than 1 year) are subjected to unnecessary radiation exposure, especially due to the use of non-optimize X-ray protocols.

Traumatic Cyclodialysis Cleft Surgical Management Using Encirclage and Cryotherapy : A Novel Approach

This is a retrospective case series of 4 patients with traumatic cyclodialysis cleft (CC) with features of hypotony and posterior segment manifestations of blunt trauma who were treated using encirclage and trans scleral cryoptherapy along with vitrectomy. Encirclage was placed anteriorly in order to support the cleft. There was closure of cleft and improvement in Intra ocular pressure (IOP) in all cases. Thus the identification and treatment of CC with encirclage in cases with varied posterior manifestation of trauma can lead to good anatomical and visual restoration.

Prevalence of Shielding in Diagnostic X-ray Centers in the Islamic Republic of Iran: A Systematic Review

Shielding has been recommended as an effective tool against radiation exposure. Several studies have published on the availability and use of shielding tools in diagnostic X-ray centers across the country and contradictory results been reported. Therefore, the aim of this systematic review was to find out the status of radiation protection in term of availability and use of shielding tools in diagnostic X-ray centers in Iran. An extensive literature search was conducted in the PubMed/Medline, Embase, ISI, Cochrane Library, SID, Magiran, IranMedex, Irandoc and Google-Scholar search engine. We also manually searched the reference lists of the relevant studies. Two authors independently assessed the eligibility of all studies and extracted data. Thirty-seven studies published from 1998 to 2019 were included in this systematic review. In all, 1089 diagnostic X-ray centers, 4439 radiographs and performance of 1472 radiographers were covered in these studies. The availability of lead apron, gonad shield and thyroid collar were ranged from 7 to 95.5%, 26.6 to 94% and 7 to 94%, respectively. Moreover, their usage was ranged from 0 to 85.5%, 0 to 35% and 0 to 38.4%, respectively. In addition, lens shield was discussed in one study with availability of 0%. During 1998 to 2019, the status of shielding had not improved across the country. Therefore adherence to the safety guideline as far as possible is required to protection patients from undue exposure to radiation.