Positive Correlation of Tissue Inhibitor of Metalloproteinase-3 and Death-Associated Protein Kinase Hypermethylation in Head and Neck Squamous Cell Carcinoma

2007 ◽  
Vol 117 (8) ◽  
pp. 1376-1380 ◽  
Author(s):  
Chetan S. Nayak ◽  
Andr?? Lopes Carvalho ◽  
Carmen Jeronimo ◽  
Rui Henrique ◽  
Michael M. Kim ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Positive Correlation ◽  
Death Associated Protein Kinase

Expression of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Head and Neck Squamous Cell Carcinoma

1997 ◽  
Vol 106 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Steven J. Charous ◽  
George P. Stricklin ◽  
James L. Netterville ◽  
Lillian B. Nanney ◽  
Brian B. Burkey
Keyword(s):  
Squamous Cell Carcinoma ◽  
Matrix Metalloproteinases ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Proteolytic Enzymes ◽  
Neck Squamous Cell Carcinoma ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Metastatic Sites

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes implicated in the invasion and metastasis of many cancers. In situ hybridization techniques were used to reveal sites of expression of collagenase (MMP-1), gelatinase 72 kd (MMP-2), gelatinase 92 kd (MMP-9), and tissue inhibitor of metalloproteinase-1 (TTMP-1) in head and neck carcinomas (N=21). Both TTMP-1 and gelatinase 72 kd were expressed in nearly all tumors, whereas the expression of collagenase and gelatinase 92 kd showed variability. Tumor-associated expression of MMPs was strongest in stromal cells near advancing margins. No differences in expression levels were detected between primary and metastatic sites. This paper reviews the literature and discusses the significance and possible implications of MMPs in head and neck squamous cell carcinoma.

scholarly journals Analysis of oncogenic activities of protein kinase D1 in head and neck squamous cell carcinoma

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Liyong Zhang ◽  
Zhihong Li ◽  
Yehai Liu ◽  
Shuping Xu ◽  
Manuj Tandon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Kinase D1

scholarly journals The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma

2016 ◽  
Vol 370 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Traci R. Tuttle ◽  
Michelle L. Mierzwa ◽  
Susanne I. Wells ◽  
Sejal R. Fox ◽  
Nira Ben-Jonathan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cyclic Gmp ◽  
Therapeutic Target ◽  
Neck Squamous Cell Carcinoma ◽  
Protein Kinase G
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