Colombian School Children With Functional Gastrointestinal Disorders Respond Differently to Family Stress Than Healthy Children

2019 ◽  
Vol 68 (4) ◽  
pp. e58-e61
Author(s):  
Peter L. Lu ◽  
Puck J.J. Blom ◽  
Qian Qian ◽  
Carlos A. Velasco-Benítez ◽  
Marc A. Benninga ◽  
...  
Keyword(s):  
School Children ◽  
Family Stress ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Healthy Children

Calprotectin (S100 A8/A9) and TNF-alpha in differential diagnosis of chronic abdominal pain in children

2017 ◽  
Vol 53 (1) ◽  
pp. 5-10
Author(s):  
Stanisław Pieczarkowski ◽  
Kinga Kowalska-Duplaga ◽  
Andrzej Wędrychowicz ◽  
Krzysztof Fyderek ◽  
Przemko Kwinta ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Chronic Abdominal Pain ◽  
Tnf Alpha ◽  
Gastrointestinal Disorders ◽  
Control Group ◽  
Healthy Children ◽  
Inflammatory Bowel

<i>Introduction:</i> Chronic abdominal pain in children is a very frequent and sometimes challenging diagnostic issue. Differential diagnosis in that cases is difficult and often connected with numerous, time-consuming, expensive, and frequently stressful diagnostic studies. The aim of the study was to establish whether fecal calprotectin concentration (FCC) and TNF-alpha may be useful in children with chronic abdominal pain to differentiate between inflammatory bowel disease (IBD), other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders. Methods. The study included patients (median age 13 years), who were assigned to functional gastrointestinal disorders group (n=33); inflammatory gastrointestinal disorders other than IBD (n=71), children with IBD (n=37) and 22 healthy children served as a control group. The concertation of FCC and TNF-alpha in stool samples was measured using ELISA. <i>Results:</i> In healthy children and in children with functional disorders FCCs were below 100 μg/g. In patients with IBD FCCs and TNF-alpha were markedly elevated as compare to children with functional gastrointestinal disorders, however using ROC discrimination of IBD patients was significantly better using FCC than TNF-alpha. <i>Conclusion:</i> FCC is better test for differentiation between IBD, other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders as compare to TNF-alpha concentration in stool. FCC as screening test in patients with chronic abdominal pain should allow to diminish unnecessary diagnostic in cases of functional gastrointestinal disorders.

scholarly journals A nationwide study on the prevalence of functional gastrointestinal disorders in school-children

2017 ◽  
Vol 74 (6) ◽  
pp. 407-412 ◽  
Author(s):  
Miguel Saps ◽  
Jairo Enrique Moreno-Gomez ◽  
Carmen Rossy Ramírez-Hernández ◽  
John M. Rosen ◽  
Carlos A. Velasco-Benitez
Keyword(s):  
School Children ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Nationwide Study

scholarly journals microecological and associative structure of intestinal biocenosis in children with functional gastrointestinal disorders

2016 ◽  
Vol 1 (5) ◽  
pp. 22-25
Author(s):  
Немченко ◽  
Ulyana Nemchenko ◽  
Савелькаева ◽  
Marina Savelkaeva ◽  
Колесникова ◽  
...  
Keyword(s):  
Large Intestine ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Healthy Children ◽  
Functional Disorders ◽  
Associative Structure ◽  
Intestinal Microbial Community ◽  
One Year ◽  
Micro Organisms ◽  
And Staphylococcus Aureus

The article is devoted to one of actual problems of gastroenterology – study of microbiocenosis of gastrointestinal tract in functional disorders. Functional gastrointestinal disorders (FGID) or minimal dysfunctions of digestion are frequent in the first months of child’s life and provoke anxiety both in parents and in pediatricians. Aim: to explore the microbial landscape and the associative structure of the microbiota of the large intestine in children with functional disorders of the gastrointestinal tract.Subjects and methods: Intestinal microbiota composition of 225 children with functional gastrointestinal disorders and 100 healthy children was studied using bacteriological method.Results. The 88.4 % frequency of detection of intestinal eubiosis disorders is discussed. Information is provided on the species composition of the major opportunistic organisms that inhabit this biotope. According to the results, decrease of bifidobacteria amount in structure of large intestine microbiota increases rate of detection of opportunistic micro-organisms – predominantly, Klebsiella genus bacteria and Staphylococcus aureus. The intestinal microbial community is dominated by multicomponent transient association. The frequency of detection of pathogenic Staphylococcus in children under one year is discussed in detail.Conclusions. A distinctive feature of the intestinal biocenosis microecological status is significantly greater spread of enterococci than in healthy children, which can be a risk for the emergence of strains with the presence of a number of pathogenecity factors that cause infectious processes.

scholarly journals A nationwide study on the prevalence of functional gastrointestinal disorders in school-children

2019 ◽  
Vol 74 (6) ◽  
Author(s):  
Miguel Saps ◽  
Jairo Enrique Moreno-Gomez ◽  
Carmen Ramírez-Hernández ◽  
John M. Rosen ◽  
Carlos A. Velasco-Benitez
Keyword(s):  
School Children ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Nationwide Study

Functional Gastrointestinal Disorders in Migrainous Children: Efficacy of Flunarizine

Cephalalgia ◽  
2006 ◽  
Vol 26 (10) ◽  
pp. 1214-1219 ◽  
Author(s):  
G Boccia ◽  
E Del Giudice ◽  
AF Crisanti ◽  
C Strisciuglio ◽  
A Romano ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Symptoms ◽  
Gastrointestinal Disorders ◽  
Healthy Children ◽  
Mean Frequency ◽  
Gastric Emptying Time ◽  
Symptom History ◽  
The Mean ◽  
Real Time Ultrasonography

The aim of this study was to evaluate the prevalence of functional gastrointestinal disorders (FGIDs) in children with migraine headache and the effects of flunarizine on gastrointestinal manifestations. We studied 50 migrainous children (mean age 8.63 years). The clinical pattern and the diagnosis of FGIDs were obtained from structured questionnaires. All subjects underwent measurement of total gastric emptying time (TGEt) performed by real-time ultrasonography of the gastric antrum at baseline (T0). In the second part of the study, we evaluated 10 migrainous children (mean age 9.8 years) with associated FGIDs. In these 10 patients, repeated TGEt evaluation together with a detailed symptom history was obtained after 1 (T1) and 2 months (T2) of treatment with flunarizine. Control groups were composed of 10 migrainous children without FGIDs (mean age 9.2 years) and nine sex- and age-matched healthy children. Gastrointestinal disorders were present in 70% of the patients. Migrainous children with FGIDs had significantly ( P < 0.01) more prolonged TGEt than subjects without FGIDs. Prior to therapy, all migrainous children with FGIDs had prolongation of TGEt compared with controls ( P < 0.05). Patients on flunarizine had a significant decrease in TGEt at both 1 ( P < 0.01) and 2 months ( P = 0.002) of therapy. The mean frequency of abdominal pain per month was significantly ( P < 0.001) reduced at T1 compared with T0. The mean frequency of vomiting per month was significantly decreased at T1 ( P < 0.05) and even more so at T2 ( P < 0.01). Finally, the mean frequency of headache per month was significantly reduced only at T2 ( P < 0.05), whereas the mean duration of headache was significantly decreased at T1 ( P < 0.01) with no difference between T1 and T2. Most children with migraine report FGIDs, associated with a delayed gastric emptying. Flunarizine decreases the frequency and duration of migrainous episodes as well as the gastrointestinal symptoms.

scholarly journals Diagnostic Value of Fecal Calprotectin (S100 A8/A9) Test in Children with Chronic Abdominal Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Stanisław Pieczarkowski ◽  
Kinga Kowalska-Duplaga ◽  
Przemko Kwinta ◽  
Przemysław Tomasik ◽  
Andrzej Wędrychowicz ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Functional Gastrointestinal Disorders ◽  
Fecal Calprotectin ◽  
Chronic Abdominal Pain ◽  
Gastrointestinal Disorders ◽  
Control Group ◽  
Healthy Children ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Objectives. The aim of the study was to establish whether fecal calprotectin concentration (FCC) may be useful in children with chronic abdominal pain to differentiate between inflammatory bowel disease (IBD), other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders. Methods. The study included 163 patients (median age 13 years), who were assigned to four study groups: group 0 (control), 22 healthy children; group 1, 33 children with functional gastrointestinal disorders; group 2, 71 children with inflammatory gastrointestinal disorders other than IBD; group 3, 37 children with IBD. FCC was measured using ELISA assay. Results. In group 0 and group 1 FCCs were below 100 μg/g. Low FCCs were found in 91% of patients in group 2. In patients with IBD FCCs were markedly elevated with median value of 1191.5 μg/g. However, in children with inflammatory gastrointestinal disorders other than IBD and in children with IBD mean FCCs were significantly higher compared with the control group. Significant differences in FCCs were also found between group 1 and group 2, between group 1 and group 3, and between group 2 and group 3. Conclusion. FCC is the best parameter allowing for differentiation between IBD, other inflammatory gastrointestinal disorders, and functional gastrointestinal disorders. High FCC is associated with a high probability of IBD and/or other inflammatory gastrointestinal disorders, and it allows excluding functional gastrointestinal disorders.

Prevalence of Functional Gastrointestinal Disorders in Colombian School Children

2014 ◽  
Vol 164 (3) ◽  
pp. 542-545.e1 ◽  
Author(s):  
Miguel Saps ◽  
Diana X. Nichols-Vinueza ◽  
John M. Rosen ◽  
Carlos Alberto Velasco-Benítez
Keyword(s):  
School Children ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders
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