Characterization of and Risk Factors for the Acute-Phase Response After Zoledronic Acid

2011 ◽  
Vol 66 (2) ◽  
pp. 97-99 ◽  
Author(s):  
I. R. Reid ◽  
G. D. Gamble ◽  
P. Mesenbrink ◽  
P. Lakatos ◽  
D. M. Black
Keyword(s):  
Risk Factors ◽  
Zoledronic Acid ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response

scholarly journals Characterization of and Risk Factors for the Acute-Phase Response after Zoledronic Acid

2010 ◽  
Vol 95 (9) ◽  
pp. 4380-4387 ◽  
Author(s):  
I. R. Reid ◽  
G. D. Gamble ◽  
P. Mesenbrink ◽  
P. Lakatos ◽  
D. M. Black
Keyword(s):  
Risk Factors ◽  
Zoledronic Acid ◽  
Adverse Events ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Drug Users ◽  
Acid Group ◽  
Antiinflammatory Drug ◽  
Nonsteroidal Antiinflammatory Drug ◽  
Phase Response

Context: Intravenous aminobisphosphonates often cause an acute-phase response (APR), but the precise components of this, its frequency, and the risk factors for its development have not been systematically studied. Objective: The objective of the study was to characterize the APR and determine its frequency and the risk factors for its development. Design: The study was an analysis of adverse events from a large randomized trial. Setting: This was a multicenter international trial. Patients: Patients included 7765 postmenopausal women with osteoporosis. Intervention: Zoledronic acid 5 mg annually or placebo was the intervention. Main Outcome Measure: Adverse events occurring within 3 d of zoledronic acid infusion were measured. Results: More than 30 adverse events were significantly more common in the zoledronic acid group and were regarded collectively as constituting an APR. These were clustered into five groups: fever; musculoskeletal (pain and joint swelling); gastrointestinal (abdominal pain, vomiting, diarrhea); eye inflammation; and general (including fatigue, nasopharyngitis, edema). A total of 42.4% of the zoledronic acid group had an APR after the first infusion, compared with 11.7% of the placebo group. All APR components had their peak onset within 1 d, the median duration of the APR was 3 d, and severity was rated as mild or moderate in 90%. Stepwise regression showed that APR was more common in non-Japanese Asians, younger subjects, and nonsteroidal antiinflammatory drug users and was less common in smokers, patients with diabetes, previous users of oral bisphosphonates, and Latin Americans (P < 0.05 for all). Conclusion: This analysis identifies new components of the APR and provides the first assessment of risk factors for it. Despite its frequency, APR rarely resulted in treatment discontinuation in this study.

scholarly journals Experimental alveolitis in rats: microbiological, acute phase response and histometric characterization of delayed alveolar healing

2011 ◽  
Vol 19 (3) ◽  
pp. 260-268 ◽  
Author(s):  
Moacyr Tadeu Vicente Rodrigues ◽  
Camila Lopes Cardoso ◽  
Paulo Sérgio Perri de Carvalho ◽  
Tânia Mary Cestari ◽  
Magda Feres ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response

Characterization of the mouse olfactory glutathioneS-transferases during the acute phase response

2003 ◽  
Vol 73 (5) ◽  
pp. 679-685 ◽  
Author(s):  
Michelle Weech ◽  
Michelle Quash ◽  
Eric Walters
Keyword(s):  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response

scholarly journals Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study

2009 ◽  
Vol 11 (1) ◽  
Author(s):  
Vaidehi R Chowdhary ◽  
Cynthia S Crowson ◽  
Kimberly P Liang ◽  
Clement J Michet ◽  
Dylan V Miller ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Case Control Study ◽  
Case Control ◽  
Phase Response ◽  
Control Study

Acute phase response and zoledronic acid therapy

2013 ◽  
Author(s):  
Svetlana Yureneva ◽  
Oksana Yakushevskaya ◽  
Vera Smetnik ◽  
Gennady Sukchich
Keyword(s):  
Zoledronic Acid ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Acid Therapy

Acute Phase Response After Zoledronic Acid is Associated with Long-Term Effects on White Blood Cells

2013 ◽  
Vol 93 (3) ◽  
pp. 249-252 ◽  
Author(s):  
Maurizio Rossini ◽  
Silvano Adami ◽  
Ombretta Viapiana ◽  
Gaia Tripi ◽  
Roberta Zanotti ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Acute Phase ◽  
Blood Cells ◽  
Acute Phase Response ◽  
White Blood Cells ◽  
Phase Response ◽  
Long Term Effects
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