scholarly journals Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression

AIDS ◽  
2010 ◽  
Vol 24 (6) ◽  
pp. 819-831 ◽  
Author(s):  
Lindi Roberts ◽  
Jo-Ann S Passmore ◽  
Carolyn Williamson ◽  
Francesca Little ◽  
Lisa M Bebell ◽  
...  
Keyword(s):  
Disease Progression ◽  
Hiv Disease ◽  
Plasma Cytokine ◽  
Cytokine Levels ◽  
Acute Hiv ◽  
Hiv 1

scholarly journals Plasma Cytokine Levels in Chronic Asymptomatic HIV-1 Subtype C Infection as an Indicator of Disease Progression in Botswana: A Retrospective Case Control Study

2016 ◽  
Vol 32 (4) ◽  
pp. 364-369 ◽  
Author(s):  
Thato Iketleng ◽  
Sikhulile Moyo ◽  
Simani Gaseitsiwe ◽  
Balthazar Nyombi ◽  
Rebecca M. Mitchell ◽  
...  
Keyword(s):  
Disease Progression ◽  
Case Control Study ◽  
Case Control ◽  
Subtype C ◽  
Retrospective Case ◽  
Plasma Cytokine ◽  
Cytokine Levels ◽  
Hiv 1 ◽  
Control Study ◽  
Asymptomatic Hiv

Plasma Cytokine Levels in Tanzanian HIV-1-Infected Adults and the Effect of Antiretroviral Treatment

2009 ◽  
Vol 52 (4) ◽  
pp. 493-497 ◽  
Author(s):  
Judith M Haissman ◽  
Lasse S Vestergaard ◽  
Samuel Sembuche ◽  
Christian Erikstrup ◽  
Bruno Mmbando ◽  
...  
Keyword(s):  
Antiretroviral Treatment ◽  
Plasma Cytokine ◽  
Cytokine Levels ◽  
Hiv 1

scholarly journals Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania

2004 ◽  
Vol 134 (10) ◽  
pp. 2556-2560 ◽  
Author(s):  
Roland Kupka ◽  
Gernard I. Msamanga ◽  
Donna Spiegelman ◽  
Steve Morris ◽  
Ferdinand Mugusi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Disease Progression ◽  
Hiv Disease ◽  
Selenium Status ◽  
Hiv 1

scholarly journals Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection

2018 ◽  
Vol 92 (19) ◽  
Author(s):  
Doty B. A. Ojwach ◽  
Daniel MacMillan ◽  
Tarylee Reddy ◽  
Vladimir Novitsky ◽  
Zabrina L. Brumme ◽  
...  
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Disease Progression ◽  
Chronic Infection ◽  
Hiv Disease ◽  
Subtype C ◽  
Recombinant Viruses ◽  
Immune Mediated ◽  
Hiv 1

ABSTRACT CD8+ T cell-mediated escape mutations in Gag can reduce HIV-1 replication capacity (RC) and alter disease progression, but less is known about immune-mediated attenuation in other HIV-1 proteins. We generated 487 recombinant viruses encoding RT-integrase from individuals with chronic (n = 406) and recent (n = 81) HIV-1 subtype C infection and measured their in vitro RC using a green fluorescent protein (GFP) reporter T cell assay. In recently infected individuals, reverse transcriptase (RT)-integrase-driven RC correlated significantly with viral load set point (r = 0.25; P = 0.03) and CD4+ T cell decline (P = 0.013). Moreover, significant associations between RT integrase-driven RC and viral load (r = 0.28; P < 0.0001) and CD4+ T cell count (r = −0.29; P < 0.0001) remained in chronic infection. In early HIV infection, host expression of the protective HLA-B*81 allele was associated with lower RC (P = 0.05), as was expression of HLA-B*07 (P = 0.02), suggesting early immune-driven attenuation of RT-integrase by these alleles. In chronic infection, HLA-A*30:09 (in linkage disequilibrium with HLA-B*81) was significantly associated with lower RC (P = 0.05), and all 6 HLA-B alleles with the lowest RC measurements represented protective alleles, consistent with long-term effects of host immune pressures on lowering RT-integrase RC. The polymorphisms V241I, I257V, P272K, and E297K in reverse transcriptase and I201V in integrase, all relatively uncommon polymorphisms occurring in or adjacent to optimally described HLA-restricted cytotoxic T-lymphocyte epitopes, were associated with reduced RC. Together, our data suggest that RT-integrase-driven RC is clinically relevant and provide evidence that immune-driven selection of mutations in RT-integrase can compromise RC. IMPORTANCE Identification of viral mutations that compromise HIV's ability to replicate may aid rational vaccine design. However, while certain escape mutations in Gag have been shown to reduce HIV replication and influence clinical progression, less is known about the consequences of mutations that naturally arise in other HIV proteins. Pol is a highly conserved protein, but the impact of Pol function on HIV disease progression is not well defined. Here, we generated recombinant viruses using the RT-integrase region of Pol derived from HIV-1C-infected individuals with recent and chronic infection and measured their ability to replicate in vitro. We demonstrate that RT-integrase-driven replication ability significantly impacts HIV disease progression. We further show evidence of immune-mediated attenuation in RT-integrase and identify specific polymorphisms in RT-integrase that significantly decrease HIV-1 replication ability, suggesting which Pol epitopes could be explored in vaccine development.

scholarly journals Meta-Analysis To Test the Association of HIV-1 nef Amino Acid Differences and Deletions with Disease Progression

2010 ◽  
Vol 84 (7) ◽  
pp. 3644-3653 ◽  
Author(s):  
Ravindra Pushker ◽  
Jean-Marc Jacqué ◽  
Denis C. Shields
Keyword(s):  
Amino Acid ◽  
Disease Progression ◽  
Meta Analysis ◽  
Amino Acid Replacement ◽  
Hiv Disease ◽  
Permutation Testing ◽  
Consensus Sequences ◽  
Subtype B ◽  
Hiv 1

ABSTRACT Previous relatively small studies have associated particular amino acid replacements and deletions in the HIV-1 nef gene with differences in the rate of HIV disease progression. We tested more rigorously whether particular nef amino acid differences and deletions are associated with HIV disease progression. Amino acid replacements and deletions in patients' consensus sequences were investigated for 153 progressor (P), 615 long-term nonprogressor (LTNP), and 2,311 unknown progressor sequences from 582 subtype B HIV-infected patients. LTNPs had more defective nefs (interrupted by frameshifts or stop codons), but on a per-patient basis there was no excess of LTNP patients with one or more defective nef sequences compared to the Ps (P = 0.47). The high frequency of amino acid replacement at residues S8, V10, I11, A15, V85, V133, N157, S163, V168, D174, R178, E182, and R188 in LTNPs was also seen in permuted datasets, implying that these are simply rapidly evolving residues. Permutation testing revealed that residues showing the greatest excess over expectation (A15, V85, N157, S163, V168, D174, R178, and R188) were not significant (P = 0.77). Exploratory analysis suggested a hypothetical excess of frameshifting in the regions 9SVIG and 118QGYF among LTNPs. The regions V10 and 152KVEEA of nef were commonly deleted in LTNPs. However, permutation testing indicated that none of the regions displayed significantly excessive deletion in LTNPs. In conclusion, meta-analysis of HIV-1 nef sequences provides no clear evidence of whether defective nef sequences or particular regions of the protein play a significant role in disease progression.

Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection

AIDS ◽  
1994 ◽  
Vol 8 (7) ◽  
pp. 879-884 ◽  
Author(s):  
Sylvie Chollet-Martin ◽  
Francois Simon ◽  
Sophie Matheron ◽  
Charles Alexandre Joseph ◽  
Carole Elbim ◽  
...  
Keyword(s):  
Plasma Cytokine ◽  
Cytokine Levels ◽  
African Patients ◽  
Hiv 1

scholarly journals High CCR5 Density on Central Memory CD4+ T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49526 ◽  
Author(s):  
Xue Yang ◽  
Yan-mei Jiao ◽  
Rui Wang ◽  
Yun-xia Ji ◽  
Hong-wei Zhang ◽  
...  
Keyword(s):  
T Cells ◽  
Disease Progression ◽  
Cd4 T Cells ◽  
Central Memory ◽  
Rapid Disease Progression ◽  
Acute Hiv ◽  
Memory Cd4 T Cells ◽  
Hiv 1
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