Reduced Heart Rate Response to Dipyridamole as a Marker of Left Ventricular Dysfunction in Diabetic Patients Undergoing Myocardial Perfusion Scintigraphy

2009 ◽  
Vol 34 (5) ◽  
pp. 275-278 ◽  
Author(s):  
Andrea De Lorenzo ◽  
Ronaldo S. L. Lima
Keyword(s):  
Heart Rate ◽  
Myocardial Perfusion ◽  
Left Ventricular Dysfunction ◽  
Heart Rate Response ◽  
Ventricular Dysfunction ◽  
Myocardial Perfusion Scintigraphy ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
Perfusion Scintigraphy

scholarly journals Myocardial perfusion scintigraphy in the detection of silent ischemia in asymptomatic diabetic patients

2013 ◽  
Vol 46 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Gláucia Celeste Rossatto Oki ◽  
Elizabeth João Pavin ◽  
Otávio Rizzi Coelho ◽  
Maria Cândida R. Parisi ◽  
Raitany C. Almeida ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Myocardial Perfusion ◽  
Myocardial Perfusion Scintigraphy ◽  
Left Ventricular ◽  
Silent Myocardial Ischemia ◽  
Diabetic Patients ◽  
Perfusion Scintigraphy ◽  
Asymptomatic Patients ◽  
History Of ◽  
Artery Disease

OBJECTIVE: This study was aimed to evaluate myocardial perfusion in asymptomatic patients with type 1 (DM1) and type 2 diabetes mellitus (DM2) without previous diagnoses of coronary artery disease (CAD) or cerebral infarction. MATERIALS AND METHODS: Fifty-nine consecutive asymptomatic patients (16 DM1, 43 DM2) underwent myocardial perfusion scintigraphy with 99mTc-sestamibi (MPS). They were evaluated for body mass index, metabolic control of DM, type of therapy, systemic arterial hypertension, dyslipidemia, nephropathy, retinopathy, peripheral neuropathy, smoking, and familial history of CAD. RESULTS: MPS was abnormal in 15 patients (25.4%): 12 (20.3%) with perfusion abnormalities, and 3 with isolated left ventricular dysfunction. The strongest predictors for abnormal myocardial perfusion were: age 60 years and above (p = 0.017; odds ratio [OR] = 6.0), peripheral neuropathy (p = 0.028; OR = 6.1), nephropathy (p = 0.031; OR = 5.6), and stress ECG positive for ischemia (p = 0.049; OR = 4.08). CONCLUSION: Silent myocardial ischemia occurs in more than one in five asymptomatic diabetic patients. The strongest predictors of ischemia in this study were: patient age, peripheral neuropathy, nephropathy, retinopathy and a stress ECG positive for ischemia.

scholarly journals Prognostic value of myocardial perfusion scintigraphy in asymptomatic patients with diabetes mellitus at high cardiovascular risk: 5-year follow-up of the prospective multicenter BARDOT trial

2021 ◽  
Author(s):  
Federico Caobelli ◽  
◽  
Philip Haaf ◽  
Gianluca Haenny ◽  
Matthias Pfisterer ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Myocardial Perfusion ◽  
Cardiovascular Events ◽  
Prognostic Value ◽  
Myocardial Perfusion Scintigraphy ◽  
Major Adverse Cardiovascular Events ◽  
Diabetic Patients ◽  
Perfusion Scintigraphy ◽  
High Cardiovascular Risk

Abstract Background The Basel Asymptomatic High-Risk Diabetics’ Outcome Trial (BARDOT) demonstrated that asymptomatic diabetic patients with an abnormal myocardial perfusion scintigraphy (MPS) were at increased risk of major adverse cardiovascular events (MACEs) at 2-year follow-up. It remains unclear whether this finding holds true even for a longer follow-up. Methods Four hundred patients with type 2 diabetes, neither history nor symptoms of coronary artery disease (CAD), were evaluated clinically and with MPS. Patients were followed up for 5 years. Major adverse cardiovascular events (MACEs) were defined as all-cause death, myocardial infarction, or late coronary revascularization. Results At baseline, an abnormal MPS (SSS ≥ 4 or SDS ≥ 2) was found in 87 of 400 patients (22%). MACE within 5 years occurred in 14 patients with abnormal MPS (16.1%) and in 22 with normal scan (1.7%), p = 0.009; 15 deaths were recorded. Patients with completely normal MPS (SSS and SDS = 0) had lower rates of MACEs than patients with abnormal scans (2.5% vs. 7.0%, p = 0.032). Patients with abnormal MPS who had undergone revascularization had a lower mortality rate and a better event-free survival from MI and revascularization than patients with abnormal MPS who had either undergone medical therapy only or could not be revascularized (p = 0.002). Conclusions MPS may have prognostic value in asymptomatic diabetic patients at high cardiovascular risk over a follow-up period of 5 years. Patients with completely normal MPS have a low event rate and may not need retesting within 5 years. Patients with an abnormal MPS have higher event rates and may benefit from a combined medical and revascularization approach.

scholarly journals Elevated resting heart rate is a marker of subclinical left ventricular dysfunction in hodgkin lymphoma survivors

2021 ◽  
Vol 35 ◽  
pp. 100830
Author(s):  
Julius C. Heemelaar ◽  
Augustinus D.G. Krol ◽  
Marloes Louwerens ◽  
Saskia L.M.A. Beeres ◽  
Eduard R. Holman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Hodgkin Lymphoma ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Left Ventricular ◽  
Resting Heart Rate ◽  
Lymphoma Survivors
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