“Reversed Halo Sign” of High-resolution Computed Tomography in Pulmonary Sarcoidosis

2009 ◽  
Vol 24 (1) ◽  
pp. 66-68 ◽  
Author(s):  
Hiroyuki Kumazoe ◽  
Kazuko Matsunaga ◽  
Nobuhiko Nagata ◽  
Masashi Komori ◽  
Kentarou Wakamatsu ◽  
...  
2019 ◽  
Vol 54 (2) ◽  
pp. 1900371 ◽  
Author(s):  
Sarah M. Ryan ◽  
Tasha E. Fingerlin ◽  
Margaret Mroz ◽  
Briana Barkes ◽  
Nabeel Hamzeh ◽  
...  

IntroductionPulmonary sarcoidosis is a rare heterogeneous lung disease of unknown aetiology, with limited treatment options. Phenotyping relies on clinical testing including visual scoring of chest radiographs. Objective radiomic measures from high-resolution computed tomography (HRCT) may provide additional information to assess disease status. As the first radiomics analysis in sarcoidosis, we investigate the potential of radiomic measures as biomarkers for sarcoidosis, by assessing 1) differences in HRCT between sarcoidosis subjects and healthy controls, 2) associations between radiomic measures and spirometry, and 3) trends between Scadding stages.MethodsRadiomic features were computed on HRCT in three anatomical planes. Linear regression compared global radiomic features between sarcoidosis subjects (n=73) and healthy controls (n=78), and identified associations with spirometry. Spatial differences in associations across the lung were investigated using functional data analysis. A subanalysis compared radiomic features between Scadding stages.ResultsGlobal radiomic measures differed significantly between sarcoidosis subjects and controls (p<0.001 for skewness, kurtosis, fractal dimension and Geary'sC), with differences in spatial radiomics most apparent in superior and lateral regions. In sarcoidosis subjects, there were significant associations between radiomic measures and spirometry, with a large association found between Geary'sCand forced vital capacity (FVC) (p=0.008). Global radiomic measures differed significantly between Scadding stages (p<0.032), albeit nonlinearly, with stage IV having more extreme radiomic values. Radiomics explained 71.1% of the variability in FVC compared with 51.4% by Scadding staging alone.ConclusionsRadiomic HRCT measures objectively differentiate disease abnormalities, associate with lung function and identify trends in Scadding stage, showing promise as quantitative biomarkers for pulmonary sarcoidosis.


2009 ◽  
Vol 24 (2) ◽  
pp. 136-137 ◽  
Author(s):  
Bruno Hochhegger ◽  
Edson Marchiori ◽  
Klaus L. Irion ◽  
Gustavo Santos de Melo ◽  
Flávia Mendes ◽  
...  

2000 ◽  
Vol 42 (3) ◽  
pp. 473
Author(s):  
Dae Sik Ryu ◽  
Kun Sang Kim ◽  
Kil Hyen Kang ◽  
Haing Sup Chung ◽  
Bung Wok Lee ◽  
...  

2000 ◽  
Vol 42 (5) ◽  
pp. 757
Author(s):  
Myung Hee Chung ◽  
Hae Giu Lee ◽  
Won Jong Yu ◽  
Hong Jun Chung ◽  
Bo Sung Yang ◽  
...  

2014 ◽  
Author(s):  
Jaime Pena ◽  
Graeme Campbell ◽  
Timo Damm ◽  
Reinhard Barkmann ◽  
Sonja Waldhausen ◽  
...  

Author(s):  
Alina S. Kovaleva ◽  
Igor V. Bukhtiyarov ◽  
Natalya S. Serova ◽  
Tatyana B. Burmistrova

Respiratory system diseases are one of the main problems in contemporary occupational medicine and exceed one fifth of all occupational diseases. Objective of the review was search and analysis of literature on diagnosis of silicosis as an important occupational disease of respiratory organs, by computed tomography and high-resolution computed tomography, from evidence-based medicine viewpoint.


1990 ◽  
Vol 31 (1) ◽  
pp. 27-31
Author(s):  
M. Isono ◽  
K. Murata ◽  
F. Ohta ◽  
A. Yoshida ◽  
O. Ishida

Author(s):  
Marco Tana ◽  
Silvio di Carlo ◽  
Marcello Romano ◽  
Massimo Alessandri ◽  
Cosima Schiavone ◽  
...  

Background:18F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (18-F-FDG-PET/CT) is getting wide consensus in the diagnosis and staging of neoplastic disorders and represents a useful tool in the assessment of various inflammatory conditions. </P><P> Discussion: Sarcoidosis is an uncommon disease characterized by the systemic formation of noncaseating granulomas. Lungs are the sites most often affected, and investigation with high resolution computed tomography and biopsy is essential to achieve a correct diagnosis. 18-F-FDGPET/ CT is effective in the assessment of pulmonary sarcoidosis by demonstrating pulmonary and extrathoracic involvement and findings correlate well with pulmonary function in patients affected.Conclusion:This review would illustrate the usefulness and limits of 18-F-FDG-PET/CT in the assessment of pulmonary sarcoidosis.


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