Mechanical Strength and In Vitro Antibiotic Release Profile of Antibiotic-Loaded Calcium Phosphate Bone Cement

2013 ◽  
Vol 24 (4) ◽  
pp. 1447-1450 ◽  
Author(s):  
Yoshiaki Sakamoto ◽  
Hiroko Ochiai ◽  
Ikuko Ohsugi ◽  
Yoshikazu Inoue ◽  
Yohko Yoshimura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Cement ◽  
Release Profile ◽  
Calcium Phosphate Bone Cement ◽  
Antibiotic Release

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

2020 ◽  
Vol 15 (5) ◽  
pp. 055038
Author(s):  
Sirirat T. Rattanachan ◽  
Nuan La-ong Srakaew ◽  
Paritat Thaitalay ◽  
Oranich Thongsri ◽  
Rawee Dangviriyakul ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Bone Cement

scholarly journals FABRICATION OF POLY(LACTIC-CO-GLYCOLIC ACID)/CALCIUM PHOSPHATE BONE CEMENT COMPOSITE: SYNTHESIZATION OF CALCIUM PHOSPHATE FROM CRAB SHELLS

2018 ◽  
Vol 80 (4) ◽  
Author(s):  
Mohammad Redzuan Abdul Hanan ◽  
Ahmad Kafrawi Nasution ◽  
Rafaqat Hussain ◽  
Syafiqah Saidin
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Glycolic Acid ◽  
Waste Product ◽  
Cement Composite ◽  
Chemical Route ◽  
Calcium Phosphate Bone Cement ◽  
Calcium Compound ◽  
Dsc Analyses

Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation..

Preliminary Study on the Biocompatibility of Calcium Phosphate Bone Cement Containing N,O-Carboxymethyl Chitosan

2007 ◽  
Vol 330-332 ◽  
pp. 807-810
Author(s):  
Qi Huang ◽  
Feng Cao ◽  
Dong Xu Li
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Normal Saline ◽  
Carboxymethyl Chitosan ◽  
In Vitro Tests ◽  
Calcium Phosphate Bone Cement ◽  
Biological Reaction ◽  
Good Biocompatibility ◽  
Preliminary Study

N,O-carboxymethyl chitosan (CMCTS) was added in Calcium phosphate bone cement (CPC). A preliminary study was carried out in order to evaluate the biocompatibility of CPC containing CMCTS. In vitro tests were done using extract liquid from normal saline. The result showed that the biological reaction complied with standards of GB/16886 and the composite might have good biocompatibility.

In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute

2021 ◽  
pp. 088532822198998
Author(s):  
Karl Wu ◽  
Yu-Chun Chen ◽  
Shang M Lin ◽  
Chih-Hung Chang
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Degradation Rate ◽  
Rabbit Model ◽  
Type I ◽  
Calcium Phosphate Bone Cement ◽  
Osteogenic Effect ◽  
Composite Bone

This study aimed to evaluate the effectiveness of a novel calcitonin-loaded calcium phosphate composite bone cement in vitro and in vivo. The novel composite bone cements were composed of NuROs injectable bone graft substitute, type I collagen, and/or salmon calcitonin. The setting time, porosity, wettability, compressive strength, compressive modulus, and crystallographic structures of cement specimens were determined. Degradation rate, calcitonin release rate, and osteoinductivity were assessed in vitro. In addition, osteogenic effect was examined in a rabbit model of femoral defect. The results revealed that addition of collagen/calcitonin did not substantially alter physical properties and degradation rate of bone cement specimens. Calcitonin was released into culture medium in a two-phase manner. Osteogenic effect of conditioned medium derived from calcitonin containing bone cement was observed. Finally, de novo bone growth and bone mineralization across the bone defect area were observed in rabbits after implantation of composite bone cement specimens. In conclusion, this novel calcitonin-loaded composite calcium phosphate bone cement exhibits biocompatibility, bioresorbability, osteoinductivity, and osteoconductivity, which may be suitable for clinical use.

Properties of Calcium Phosfate Cement with Addition of Dispersant and Hydrogel

2012 ◽  
Vol 727-728 ◽  
pp. 1170-1174 ◽  
Author(s):  
J.M. Fernandes ◽  
W.T. Coelho ◽  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
In Vitro Test ◽  
Polymeric Additives ◽  
Calcium Phosphate Bone Cement ◽  
Vitro Test ◽  
Good Biocompatibility

The calcium phosphate cements (CPCs) have attracted great interest for use in orthopedics and dentistry as replacements for damaged parts of the skeletal system,showing good biocompatibility and osseointegration. These characteristics allow its use as a bone graft.Several studies in literature have shown that the addition of polymeric additives has a strong influence on the mechanical properties of cement. The low mechanical strength is the main impediment to a broader use of calcium phosphate bone cement (CPCs) as implant material. The aim of this work was evaluate the strength of a CPC based on α-tricalcium phosphate, with polymeric additions. CPC was synthesized and sodium alginate were added (1%, 2% and 3% by weight) and ammonium polyacrylate (3%; dispersant) in aqueous solution. Specimens were molded and evaluated for density, pH, porosity, in vitro test (Simulated Body Fluid),crystalline phases and mechanical strength. The results show the increase of the mechanical properties of cement when added with sodium alginate and dispersant.

Modulation of Alendronate release from a calcium phosphate bone cement: An in vitro osteoblast-osteoclast co-culture study

2019 ◽  
Vol 554 ◽  
pp. 245-255 ◽  
Author(s):  
Luisa Stella Dolci ◽  
Silvia Panzavolta ◽  
Paola Torricelli ◽  
Beatrice Albertini ◽  
Laura Sicuro ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Culture Study ◽  
Calcium Phosphate Bone Cement
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