Properties of Calcium Phosfate Cement with Addition of Dispersant and Hydrogel

2012 ◽  
Vol 727-728 ◽  
pp. 1170-1174 ◽  
Author(s):  
J.M. Fernandes ◽  
W.T. Coelho ◽  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
In Vitro Test ◽  
Polymeric Additives ◽  
Calcium Phosphate Bone Cement ◽  
Vitro Test ◽  
Good Biocompatibility

The calcium phosphate cements (CPCs) have attracted great interest for use in orthopedics and dentistry as replacements for damaged parts of the skeletal system,showing good biocompatibility and osseointegration. These characteristics allow its use as a bone graft.Several studies in literature have shown that the addition of polymeric additives has a strong influence on the mechanical properties of cement. The low mechanical strength is the main impediment to a broader use of calcium phosphate bone cement (CPCs) as implant material. The aim of this work was evaluate the strength of a CPC based on α-tricalcium phosphate, with polymeric additions. CPC was synthesized and sodium alginate were added (1%, 2% and 3% by weight) and ammonium polyacrylate (3%; dispersant) in aqueous solution. Specimens were molded and evaluated for density, pH, porosity, in vitro test (Simulated Body Fluid),crystalline phases and mechanical strength. The results show the increase of the mechanical properties of cement when added with sodium alginate and dispersant.

Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphate/poly-dl-lactide-co-glycolide biocomposites and different phosphate materials

2006 ◽  
Vol 69 (12) ◽  
pp. 976-982 ◽  
Author(s):  
Nenad Ignjatović ◽  
Petar Ninkov ◽  
Vesna Kojić ◽  
Miloš Bokurov ◽  
Vladimir Srdić ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
In Vitro Test ◽  
Vitro Test

scholarly journals Organic/Inorganic bioactive materials Part III: in vitro bioactivity of gelatin/silicocarnotite hybrids

2009 ◽  
Vol 7 (4) ◽  
pp. 721-730 ◽  
Author(s):  
Lachezar Radev ◽  
Maria Fernandes ◽  
Isabel Salvado ◽  
Daniela Kovacheva
Keyword(s):  
Calcium Phosphate ◽  
Hybrid Materials ◽  
Calcium Phosphates ◽  
Ceramic Powder ◽  
Structure Evolution ◽  
In Vitro Test ◽  
In Vitro Bioactivity ◽  
Bioactive Materials ◽  
Vitro Test

AbstractIn this work we present our experimental results on synthesis, structure evolution and in vitro bioactivity assessment of new gelatin/silicocarnotite hybrid materials. The hybrids were obtained by diluting gelatin (G) and silicocarnotite (S) ceramic powder with G:S ratios of 75:25 and 25:75 wt.% in hot (40°C) water. The hybrids were characterized using XRD, FTIR, SEM/EDS and XPS. FTIR depicts that the “red shift” of amide I and COO− could be attributed to the fact that the gelatin prefers to chelate Ca2+ from S. The growth of calcium phosphates on the surface of the hybrids synthesized and then immersed in 1.5 SBF for 3 days was studied by using of FTIR, XRD and SEM/EDS. According to FTIR results, after an immersion of 3 days, A and B-type CO3HA can be observed on the surface. XRD results indicate the presence of hydroxyapatite with well defined crystallinity. SEM/EDS of the precipitated layers show the presence of CO3HA and amorphous calcium phosphate on the surface of samples with different G/S content when immersed in 1.5 SBF. XPS of the G/S hybrid with 25:75 wt.% proved the presence of Ca-deficient hydroxyapatite after an in vitro test for 3 days.

Characteristics and Biocompatibility of the Hydroxyapatite Based Two Ternary Biocomposites

2016 ◽  
Vol 720 ◽  
pp. 130-140
Author(s):  
Berrak Bulut ◽  
Ziya Engin Erkmen ◽  
Eyup Sabri Kayali
Keyword(s):  
Mechanical Properties ◽  
Physical And Mechanical Properties ◽  
Secondary Phase ◽  
In Vitro Test ◽  
Compression Tests ◽  
Vitro Test ◽  
Dental Applications ◽  
The Ideal

Hydroxyapatite (HA) is a very popular bioceramic for orthopedic and dental applications. Although HA has excellent biocompatibility, its inferior mechanical properties make it unsuitable for load-bearing implant applications. Therefore, HA should be strengthened by a secondary phase for robust mechanical properties. The aim of this study was to compare the properties of HA-Al2O3 (HAC) and HA-ZrO2 (HZC) composites with the addition of 5 and 10 wt% commercial inert glass (CIG); independently. The mixture powders were pressed and then, the pellets were sintered between 1000-1300 °C for 4 hours. Microstructural characterizations were carried out using SEM + EDS and XRD, while hardness and compression tests were done to measure mechanical properties. In order to investigate the biocompatibility behavior of the samples in vitro and in vivo tests were performed. The mechanical properties of HAC composites increased with rising CIG content and increasing sintering temperature. For HZC composites, increasing CIG content caused an elevation in hardness and a decrease in compressive strength values at 1300 °C. The composites having the best physical and mechanical properties also showed improved bioactive properties at in vitro test. In this study, the ideal composite was selected as HZC5 sintered at 1200 °C depending on the microstructure, mechanical and biocompatibility properties.

Mechanical Strength and In Vitro Antibiotic Release Profile of Antibiotic-Loaded Calcium Phosphate Bone Cement

2013 ◽  
Vol 24 (4) ◽  
pp. 1447-1450 ◽  
Author(s):  
Yoshiaki Sakamoto ◽  
Hiroko Ochiai ◽  
Ikuko Ohsugi ◽  
Yoshikazu Inoue ◽  
Yohko Yoshimura ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Cement ◽  
Release Profile ◽  
Calcium Phosphate Bone Cement ◽  
Antibiotic Release

scholarly journals PREPARATION AND IN VITRO TEST OF APATITE FILMS ONTO TITANIUM BY SPUTTERING FROM CALCIUM PHOSPHATE POWDER TARGETS

1999 ◽  
Vol 10 (0) ◽  
pp. 370-374
Author(s):  
JUN-ICHI HAMAGAMI ◽  
DAISUKE KOKUBU ◽  
KIYOSHI KANAMURA ◽  
TAKAO UMEGAKI ◽  
KIMIHIRO YAMASHITA
Keyword(s):  
Calcium Phosphate ◽  
In Vitro Test ◽  
Phosphate Powder ◽  
Vitro Test

Preliminary Study on the Biocompatibility of Calcium Phosphate Bone Cement Containing N,O-Carboxymethyl Chitosan

2007 ◽  
Vol 330-332 ◽  
pp. 807-810
Author(s):  
Qi Huang ◽  
Feng Cao ◽  
Dong Xu Li
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Normal Saline ◽  
Carboxymethyl Chitosan ◽  
In Vitro Tests ◽  
Calcium Phosphate Bone Cement ◽  
Biological Reaction ◽  
Good Biocompatibility ◽  
Preliminary Study

N,O-carboxymethyl chitosan (CMCTS) was added in Calcium phosphate bone cement (CPC). A preliminary study was carried out in order to evaluate the biocompatibility of CPC containing CMCTS. In vitro tests were done using extract liquid from normal saline. The result showed that the biological reaction complied with standards of GB/16886 and the composite might have good biocompatibility.

Evaluation of α-Tricalcium Phosphate Cement Obtained at Different Temperatures

2012 ◽  
Vol 727-728 ◽  
pp. 1187-1192 ◽  
Author(s):  
Rafaela Silveira Vieira ◽  
Wilbur Trajano Guerin Coelho ◽  
Mônica Beatriz Thürmer ◽  
Juliana Machado Fernandes ◽  
Luis Alberto Santos
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Setting Time ◽  
Calcium Pyrophosphate ◽  
In Vitro Test ◽  
Calcium Phosphate Cements ◽  
Similar Chemical ◽  
Different Temperatures ◽  
Vitro Test

The calcium phosphate cements (CPCs) based on α-tricalcium phosphate (α-TCP) are highly attractive for use in medicine and odontology, since they have similar chemical and phase composition of mineral phase of bones (calcium deficient hydroxyapatite (CDHA)). However, one of the biggest difficulties for use of this type of cement is its low mechanical strength due to the presence of undesirable phases, such as β-tricalcium phosphate. The route for obtaining α-TCP is at high temperature by solid state reaction, mixing calcium carbonate and calcium pyrophosphate. The aim of this work was to obtain calcium phosphate cements with improved strength, by studying the obtaining of α-TCP at temperatures of 1300, 1400 and 1500°C. The samples were analyzed by crystalline phases, pH, setting time, particle size, in vitro test (Simulated Body Fluid), porosity, density and compressive strength. The results show that the synthesis temperatures influence strongly the phases of powders obtained and the mechanical properties of cement, being unnecessary quenching for obtaining pure α-TCP.

Biocompatibility of Alginate -Graphene Oxide Film for Tissue Engineering Applications

2021 ◽  
Vol 900 ◽  
pp. 26-33
Author(s):  
Ishraq Abd Ulrazzaq Kadhim
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Sodium Alginate ◽  
Cell Lines ◽  
In Vitro Test ◽  
Solvent Casting ◽  
Ftir Analysis ◽  
Casting Method ◽  
Vitro Test

The present paper indicates promising potential of Sodium Alginate) Alg)/Graphene oxide (Go) films in fields bone tissue engineering (TE). The Sodium Alginate (Alg)/Graphene oxide (Go) films, were fabricated via (solvent casting method). The interaction of Sodium Alginate (Alg) with Graphene oxide (Go) via hydrogen bonding was confirmed by FTIR analysis. The swelling degree of Sodium Alginate (Alg)/Graphene oxid (Go) films was also studied. Furthermore, the biocompatibility of Sodium Alginate (Alg)/Graphene oxide (Go) films disclosed its non-cytotoxic effect on the cell lines (MG-63) in-vitro test, the viability of cell lines on the films, and hence its appropriateness as potent biomaterial for tissue engineering.

scholarly journals Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

2015 ◽  
Vol 25 ◽  
pp. 347-355 ◽  
Author(s):  
Atsuo Ito ◽  
Yu Sogo ◽  
Atsushi Yamazaki ◽  
Mamoru Aizawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Test Methods ◽  
In Vitro Test ◽  
Calcium Phosphate Ceramics ◽  
Interlaboratory Studies ◽  
Vitro Test

scholarly journals Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

2010 ◽  
Vol 8 (2) ◽  
pp. 278-284 ◽  
Author(s):  
Lachezar Radev ◽  
Vladimir Hristov ◽  
Maria Fernandes ◽  
Isabel Salvado
Keyword(s):  
Calcium Phosphate ◽  
Hybrid Materials ◽  
Red Shift ◽  
In Vitro Test ◽  
Bioactive Materials ◽  
Phosphate Silicate ◽  
Vitro Test ◽  
In Vitro Assessment

AbstractBiohybrids consisting of gelatin (G) and calcium phosphate silicate/wollastonite (CPS/W) have not been prepared so far. In this work our results are focused on the possibility of obtaining G-CPS/W bioactive hybrids in vitro. XRD, FTIR, SEM/EDS techniques were employed to characterize the synthesized hybrid materials. FTIR shows that before immersion in 1.5 SBF the “red shift” of COO- band for pure G is observed. The presence of this bond could be attributed to the formation of COO-Ca2+ via non-biomimetic route. After immersion in 1.5 SBF, FTIR shows the presence of A- and B-type carbonate containing hydroxyapatite (A/B-CO3HA). ESD and FTIR show that small amount of calcite (CaCO3) are present after in vitro test in 1.5 SBF for 3 days. XRD reveals that CO3HA and small amounts of CaCO3 can be detected after in vitro test. SEM results obtained for immersed samples show that hydroxyapatite (HA) particles fully covered the surface of the hybrids by a layer composed of spherulites. At higher magnification, very small elongated crystallites could be observed.

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