Serum Levels of Branched Chain Amino Acids Predict Duration of Cardiovascular Organ Failure in Septic Shock

Shock ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michael A. Puskarich ◽  
Cora McHugh ◽  
Thomas L. Flott ◽  
Alla Karnovsky ◽  
Alan E. Jones ◽  
...  
Keyword(s):  
Amino Acids ◽  
Septic Shock ◽  
Organ Failure ◽  
Serum Levels ◽  
Branched Chain Amino Acids ◽  
Branched Chain

Dynamic Change of Serum Levels of Some Branched-Chain Amino Acids and Tryptophan in Athletic Horses After Different Physical Exercises

2019 ◽  
Vol 77 ◽  
pp. 12-16 ◽  
Author(s):  
Francesca Arfuso ◽  
Anna Assenza ◽  
Francesco Fazio ◽  
Maria Rizzo ◽  
Claudia Giannetto ◽  
...  
Keyword(s):  
Amino Acids ◽  
Dynamic Change ◽  
Serum Levels ◽  
Branched Chain Amino Acids ◽  
Physical Exercises ◽  
Branched Chain

scholarly journals Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3106
Author(s):  
Alexander Christian Reisinger ◽  
Florian Posch ◽  
Gerald Hackl ◽  
Gunther Marsche ◽  
Harald Sourij ◽  
...  
Keyword(s):  
Amino Acids ◽  
Septic Shock ◽  
Nmr Spectroscopy ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Outcome Prediction ◽  
Branched Chain Amino Acids ◽  
Proton Nuclear Magnetic Resonance ◽  
Branched Chain ◽  
And Control

Sepsis biomarkers and potential therapeutic targets are urgently needed. With proton nuclear magnetic resonance (1H NMR) spectroscopy, several metabolites can be assessed simultaneously. Fifty-three adult medical ICU sepsis patients and 25 ICU controls without sepsis were prospectively enrolled. 1H NMR differences between groups and associations with 28-day and ICU mortality were investigated. In multivariate metabolomic analyses, we found separate clustering of ICU controls and sepsis patients, as well as septic shock survivors and non-survivors. Lipoproteins were significantly different between sepsis and control patients. Levels of the branched-chain amino acids (BCAA) valine (median 43.3 [29.0–53.7] vs. 64.3 [47.7–72.3] normalized signal intensity units; p = 0.005), leucine (57.0 [38.4–71.0] vs. 73.0 [54.3–86.3]; p = 0.034) and isoleucine (15.2 [10.9–21.6] vs. 17.9 [16.1–24.4]; p = 0.048) were lower in patients with septic shock compared to those without. Similarly, BCAA were lower in ICU non-survivors compared to survivors, and BCAA were good discriminators for ICU and 28-day mortality. In uni- and multivariable logistic regression analyses, higher BCAA levels were associated with decreased ICU- and 28-day mortality. In conclusion, metabolomics using 1H NMR spectroscopy showed encouraging potential for personalized medicine in sepsis. BCAA was significantly lower in sepsis non-survivors and may be used as early biomarkers for outcome prediction.

scholarly journals Correction to: Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes

Metabolomics ◽  
2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Allison L. O’Kell ◽  
Clive Wasserfall ◽  
Joy Guingab‑Cagmat ◽  
Bobbie‑Jo M. Webb‑Robertson ◽  
Mark A. Atkinson ◽  
...  
Keyword(s):  
Amino Acids ◽  
Serum Levels ◽  
Branched Chain Amino Acids ◽  
Metabolomic Analysis ◽  
Branched Chain

scholarly journals Electroencephalograms in a Case of Maple Syrup Urine Disease: Their Relation to Serum Levels of Branched-Chain Amino Acids

1976 ◽  
Vol 120 (2) ◽  
pp. 191-195 ◽  
Author(s):  
KAZUIE IINUMA ◽  
TAKASHI SAITO ◽  
YOSHIRO WADA ◽  
AKIRA ONUMA ◽  
NORIMITSU TAKAMATSU ◽  
...  
Keyword(s):  
Amino Acids ◽  
Maple Syrup Urine Disease ◽  
Serum Levels ◽  
Branched Chain Amino Acids ◽  
Maple Syrup ◽  
Urine Disease ◽  
Branched Chain

Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes

Metabolomics ◽  
2021 ◽  
Vol 17 (11) ◽  
Author(s):  
Allison L. O’Kell ◽  
Clive Wasserfall ◽  
Joy Guingab-Cagmat ◽  
Bobbie-Jo M. Webb-Roberston ◽  
Mark A. Atkinson ◽  
...  
Keyword(s):  
Amino Acids ◽  
Serum Levels ◽  
Branched Chain Amino Acids ◽  
Metabolomic Analysis ◽  
Branched Chain

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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