scholarly journals Novel Ex-Vivo Thrombolytic Reconditioning of Kidneys Retrieved 4 to 5 Hours after Circulatory Death

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michael Olausson ◽  
Deepti Antony ◽  
Galina Travnikova ◽  
Martin Johansson ◽  
Nikhil B. Nayakawde ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Circulatory Death

Donation after Brain Death versus Donation after Circulatory Death: Lung Donor Management Issues

2018 ◽  
Vol 39 (02) ◽  
pp. 138-147 ◽  
Author(s):  
Bronwyn Levvey ◽  
Kovi Levin ◽  
Miranda Paraskeva ◽  
Glen Westall ◽  
Gregory Snell
Keyword(s):  
Brain Death ◽  
Ex Vivo ◽  
Scoring Systems ◽  
Donation After Circulatory Death ◽  
Donor Pool ◽  
Ex Vivo Lung Perfusion ◽  
Conversion Rates ◽  
Donor Lung ◽  
Donation After Brain Death ◽  
Circulatory Death

AbstractLung transplantation (LTx) has traditionally been limited by a lack of suitable donor lungs. With the recognition that lungs are more robust than initially thought, the size of the donor pool of available lungs has increased dramatically in the past decade. Donation after brain death (DBD) and donation after circulatory death (DCD) lungs, both ideal and extended are now routinely utilized. DBD lungs can be damaged. There are important differences in the public's understanding, legal and consent processes, intensive care unit strategies, lung pathophysiology, logistics, and potential-to-actual donor conversion rates between DBD and DCD. Notwithstanding, the short- and long-term outcomes of LTx from any of these DBD versus DCD donor scenarios are now similar, robust, and continue to improve. Large audits suggest there remains a large untapped pool of DCD (but not DBD) lungs that may yet further dramatically increase lung transplant numbers. Donor scoring systems that might predict the donor conversion rates and lung quality, the role of ex vivo lung perfusion as an assessment and lung resuscitation tool, as well as the potential of donor lung quality biomarkers all have immense promise for the clinical field.

scholarly journals Steroids Limit Myocardial Edema During Ex Vivo Perfusion of Hearts Donated After Circulatory Death

2018 ◽  
Vol 105 (6) ◽  
pp. 1763-1770 ◽  
Author(s):  
Jaskiran K. Sandha ◽  
Christopher W. White ◽  
Alison Müller ◽  
Emma Avery ◽  
James Thliveris ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Myocardial Edema ◽  
Ex Vivo Perfusion ◽  
Circulatory Death

scholarly journals Reduced-flow ex vivo lung perfusion to rehabilitate lungs donated after circulatory death

2020 ◽  
Vol 39 (1) ◽  
pp. 74-82
Author(s):  
Jared P. Beller ◽  
Matthew R. Byler ◽  
Dustin T. Money ◽  
William Z. Chancellor ◽  
Aimee Zhang ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Lung Perfusion ◽  
Ex Vivo Lung Perfusion ◽  
Circulatory Death ◽  
Reduced Flow

scholarly journals Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death

2015 ◽  
Vol 99 (12) ◽  
pp. 2494-2503 ◽  
Author(s):  
Matthew L. Stone ◽  
Ashish K. Sharma ◽  
Valeria R. Mas ◽  
Ricardo C. Gehrau ◽  
Daniel P. Mulloy ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Ex Vivo ◽  
Adenosine A2a Receptor ◽  
Ex Vivo Perfusion ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Circulatory Death

Adult heart transplantation with distant procurement and ex-vivo preservation of donor hearts after circulatory death: a case series

The Lancet ◽  
2015 ◽  
Vol 385 (9987) ◽  
pp. 2585-2591 ◽  
Author(s):  
Kumud K Dhital ◽  
Arjun Iyer ◽  
Mark Connellan ◽  
Hong C Chew ◽  
Ling Gao ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Ex Vivo ◽  
Case Series ◽  
Adult Heart ◽  
Circulatory Death

scholarly journals Ex vivo analysis of graft viability using 31P magnetic resonance imaging spectroscopy

2021 ◽  
Vol 108 (Supplement_4) ◽  
Author(s):  
A Longchamp ◽  
A Klauser ◽  
T Agius ◽  
J Songeon ◽  
A Nastasi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Ex Vivo ◽  
High Energy ◽  
Warm Ischemia ◽  
Kidney Graft ◽  
Resonance Imaging ◽  
Atp Levels ◽  
Kidney Perfusion ◽  
Circulatory Death

Abstract Objective Expansion in organ supply has been proposed through the use of organs after circulatory death (donation after circulatory death [DCD]) in order to face the chronic shortage of kidneys for transplantation. However, many DCD grafts are discarded because of long warm ischemia times, and the absence of reliable non-invasive means to determine kidney viability. P magnetic resonance imaging (pMRI) spectroscopy is a noninvasive method to detect high-energy phosphate metabolites, such as ATP. However, the reliability of pMRI to predict kidney energy state, and its viability before transplantation remain also unknown. Methods To mimic DCD, pig kidneys underwent 0, 30 min or 60 min of warm ischemia, before oxygenated hypothermic machine perfusion (HMP). During the ex vivo perfusion, we assessed energy metabolites and Gadolinium elimination using pMRI. Each sample underwent histopathological scoring. Results Using pMRI, we found that in pig kidney, ATP was rapidly generated in presence of oxygen (100 kPa), which remained stable up to 22 h. Warm ischemia (60 min) induced significant histological damages, delayed cortical and medullary Gadolinium elimination (perfusion), and reduced ATP levels, but not its precursors (AMP). Finally, ATP levels and kidney perfusion both inversely correlated with the severity of kidney histological injury. Conclusion ATP levels, and kidney perfusion measurements using pMRI, are biomarkers of kidney injury after warm ischemia. Future work will define the role of pMRI in predicting kidney graft viability and patient's survival.

scholarly journals TREATING CIRCULATORY DEATH DONOR KIDNEYS WITH ANTI-FIBROTIC DRUGS USING EX VIVO PRECISION CUT KIDNEY SLICES

2020 ◽  
Vol 104 (S3) ◽  
pp. S359-S359
Author(s):  
Leonie van Leeuwen ◽  
Mitchel Ruigrok ◽  
Peter Olinga ◽  
Henri Leuvenink
Keyword(s):  
Ex Vivo ◽  
Kidney Slices ◽  
Circulatory Death
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