scholarly journals Revealing new dynamical patterns in a reaction–diffusion model with cyclic competition via a novel computational framework

Author(s):  
A. Cangiani ◽  
E. H. Georgoulis ◽  
A. Yu. Morozov ◽  
O. J. Sutton

Understanding how patterns and travelling waves form in chemical and biological reaction–diffusion models is an area which has been widely researched, yet is still experiencing fast development. Surprisingly enough, we still do not have a clear understanding about all possible types of dynamical regimes in classical reaction–diffusion models, such as Lotka–Volterra competition models with spatial dependence. In this study, we demonstrate some new types of wave propagation and pattern formation in a classical three species cyclic competition model with spatial diffusion, which have been so far missed in the literature. These new patterns are characterized by a high regularity in space, but are different from patterns previously known to exist in reaction–diffusion models, and may have important applications in improving our understanding of biological pattern formation and invasion theory. Finding these new patterns is made technically possible by using an automatic adaptive finite element method driven by a novel a posteriori error estimate which is proved to provide a reliable bound for the error of the numerical method. We demonstrate how this numerical framework allows us to easily explore the dynamical patterns in both two and three spatial dimensions.

2021 ◽  
Author(s):  
Tiankai Zhao ◽  
Yubing Sun ◽  
Xin Li ◽  
Mehdi Baghaee ◽  
Yuenan Wang ◽  
...  

Reaction-diffusion models have been widely used to elucidate pattern formation in developmental biology. More recently, they have also been applied in modeling cell fate patterning that mimic early-stage human development events utilizing geometrically confined pluripotent stem cells. However, the traditional reaction-diffusion equations could not satisfactorily explain the concentric ring distributions of various cell types, as they do not yield circular patterns even for circular domains. In previous mathematical models that yield ring patterns, certain conditions that lack biophysical understandings had been considered in the reaction-diffusion models. Here we hypothesize that the circular patterns are the results of the coupling of the mechanobiological factors with the traditional reaction-diffusion model. We propose two types of coupling scenarios: tissue tension-dependent diffusion flux and traction stress-dependent activation of signaling molecules. By coupling reaction-diffusion equations with the elasticity equations, we demonstrate computationally that the contraction-reaction-diffusion model can naturally yield the circular patterns.


2016 ◽  
Vol 8 (8) ◽  
pp. 861-868 ◽  
Author(s):  
M. Hagiwara

The mechanisms of 2D pattern formation in bronchial epithelial cells were dynamically analyzed by controlled cell culture and a reaction-diffusion model.


1995 ◽  
Vol 03 (04) ◽  
pp. 987-997 ◽  
Author(s):  
P. K. MAINI

We review some recent work investigating a hierarchy of patterning processes in which a reaction-diffusion model forms the top level. In one such hierarchy, it is assumed that the boundary is differentiated, and it is shown that this can greatly enhance the robustness of the patterns subsequently formed by the reaction-diffusion model. In the second, a spatial heterogeneity in background environment is first set-up by a simple gradient model. The resulting patterns produced by the reaction-diffusion system may be isolated to specific parts of the domain. The application of such hierarchical models to skeletal patterning in the tetrapod limb is considered.


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