scholarly journals Further researches on the extrusion of granules by trypanosomes and on their further development

In March, 1911, in the course of some work on trypanosomes carried out at the Wellcome Tropical Research Laboratories, Khartoum, the extrusion of certain granules from trypanosomes was observed by one of us (W. B. F.). The Director of the Laboratories, Dr. Andrew Balfour, was informed of these observations, and he himself shortly after observed a somewhat similar extrusion of granules from Spirochætes (spirochætosis of fowls), an account of which he published. In June, 1911, a preliminary note on the subject was communicated to the Royal Society by one of us (W. B. F.). Since then, a great deal of work has been done on the subject by us conjointly, but for the most part independently; by one of us (W. B. F.) at Khartoum and in London, by the other (H. S. R.) at Yei in the Lado Enclave.

1972 ◽  
Vol 37 (4) ◽  
pp. 677-682 ◽  
Author(s):  
George Metakides

Let α be a limit ordinal with the property that any “recursive” function whose domain is a proper initial segment of α has its range bounded by α. α is then called admissible (in a sense to be made precise later) and a recursion theory can be developed on it (α-recursion theory) by providing the generalized notions of α-recursively enumerable, α-recursive and α-finite. Takeuti [12] was the first to study recursive functions of ordinals, the subject owing its further development to Kripke [7], Platek [8], Kreisel [6], and Sacks [9].Infinitary logic on the other hand (i.e., the study of languages which allow expressions of infinite length) was quite extensively studied by Scott [11], Tarski, Kreisel, Karp [5] and others. Kreisel suggested in the late '50's that these languages (even which allows countable expressions but only finite quantification) were too large and that one should only allow expressions which are, in some generalized sense, finite. This made the application of generalized recursion theory to the logic of infinitary languages appear natural. In 1967 Barwise [1] was the first to present a complete formalization of the restriction of to an admissible fragment (A a countable admissible set) and to prove that completeness and compactness hold for it. [2] is an excellent reference for a detailed exposition of admissible languages.


1832 ◽  
Vol 122 ◽  
pp. 539-574 ◽  

I have for some time entertained an opinion, in common with some others who have turned their attention tot he subject, that a good series of observations with a Water-Barometer, accurately constructed, might throw some light upon several important points of physical science: amongst others, upon the tides of the atmosphere; the horary oscillations of the counterpoising column; the ascending and descending rate of its greater oscillations; and the tension of vapour at different atmospheric temperatures. I have sought in vain in various scientific works, and in the Transactions of Philosophical Societies, for the record of any such observations, or for a description of an instrument calculated to afford the required information with anything approaching to precision. In the first volume of the History of the French Academy of Sciences, a cursory reference is made, in the following words, to some experiments of M. Mariotte upon the subject, of which no particulars appear to have been preserved. “Le même M. Mariotte fit aussi à l’observatoire des experiences sur le baromètre ordinaire à mercure comparé au baromètre à eau. Dans l’un le mercure s’eléva à 28 polices, et dans Fautre l’eau fut a 31 pieds Cequi donne le rapport du mercure à l’eau de 13½ à 1.” Histoire de I'Acadérmie, tom. i. p. 234. It also appears that Otto Guricke constructed a philosophical toy for the amusement of himself and friends, upon the principle of the water-barometer; but the column of water probably in this, as in all the other instances which I have met with, was raised by the imperfect rarefaction of the air in the tube above it, or by filling with water a metallic tube, of sufficient length, cemented to a glass one at its upper extremity, and fitted with a stop-cock at each end; so that when full the upper one might be closed and the lower opened, when the water would fall till it afforded an equipoise to the pressure of the atmo­sphere. The imperfections of such an instrument, it is quite clear, would render it totally unfit for the delicate investigations required in the present state of science; as, to render the observations of any value, it is absolutely necessary that the water should be thoroughly purged of air, by boiling, and its insinuation or reabsorption effectually guarded against. I was convinced that the only chance of securing these two necessary ends, was to form the whole length of tube of one piece of glass, and to boil the water in it, as is done with mercury in the common barometer. The practical difficulties which opposed themselves to such a construction long appeared to me insurmount­able; but I at length contrived a plan for the purpose, which, having been honoured with the approval of the late Meteorological Committee of this Society, was ordered to be carried into execution by the President and Council.


2022 ◽  
pp. 217-234
Author(s):  
Andi Johnson ◽  
Richard Lessey ◽  
Rebeca Ramos O'Reilly ◽  
Jessica Shi

The researchers explored the dual experience of individuals who are both taking dance and movement classes digitally at the same time as they are also teaching dance and movement classes digitally. By focusing on this duality through a series of interviews with practitioners, the researchers explore how the learner/educators do or do not adapt one set of skills into the other area of work and the lessons learned from this reflective practice. The results are analyzed and broken down into five sections: glitches of the practice, reflective practice, active learning, engagement, and reframing communication. Through further analysis, the researchers explore possibilities for shifting the mindset around digital education methods. The researchers then offer suggestions for further development in the field and where further research can expand on the subject area.


There are a number of references in the scientific literature to a burning mirror designed by Sir Isaac Newton (1). Together, they record that it was made from seven separate concave glasses, each about a foot in diameter, that Newton demonstrated its effects at several meetings of the Royal Society and that he presented it to the Society. Nonetheless, neither the earliest published list of instruments possessed by the Royal Society nor the most recent one mentions the burning mirror; the latest compiler does not even include it amongst those items, once owned, now lost. No reference to the instrument apparently survives in the Society’s main records. It is not listed by the author of the recent compendium on Newton’s life and work (2). There is, however, some contemporary information still extant (Appendix 1). Notes of the principles of its design and some of its effects are to be found in the Society’s Journal Book for 1704; some of the dimensions and the arrangement of the mirrors are given in a Lexicon published by John Harris which he donated to the Royal Society at the same meeting, 12 July 1704, at which Newton gave the Society the speculum. The last reference in the Journal Book is dated 15 November that year, when Mr Halley, the then secretary to the Society, was desired to draw up an account of the speculum and its effects (3). No such account appears to have been presented to the Royal Society. There is no reference in Newton’s published papers and letters of his chasing Halley to complete the task, nor is there any mention of it in the general references to Halley. The latter was, of course, quite accustomed to performing odd jobs for Newton; that same year he was to help the Opticks through the press. The only other contemporary reference to the burning mirror, though only hearsay evidence since Flamsteed was not present at the meeting, is in a letter the latter wrote to James Pound; this confirms that there were seven mirrors and that the aperture of each was near a foot in diameter (4). Because John Harris gave his Dictionary to the Royal Society in Newton’s presence, it is reasonable to assume that his description is accurate. As Newton would hardly have left an inaccurate one unchallenged, then, belatedly, the account desired of Mr Halley can be presented. In some respects, the delay is advantageous, since the subject of radiant heat and its effects, although already by Newton’s period an ancient one, is today rather better understood. On the other hand, some data has to be inferred, that could have been measured, and some assumptions made about Newton’s procedures and understanding that could have been checked (5).


1862 ◽  
Vol 152 ◽  
pp. 511-559 ◽  

In offering to the Royal Society the ensuing Supplement to my two former papers on the Law of Mortality, with subsequent remarks on invalidism, I am anxious to acknowledge that I have derived great advantage from the encouragement and persuasion of my esteemed brother-in-law, Sir Moses Montefiore, Bart., given me to endeavour to com­pile and publish some of my later observations on the subject; knowing that, though I felt flattered by the attention originally shown by scientific gentlemen to these papers, they appeared to me capable of advantageous illustrations. Therefore I may venture to hope that if this Supplement merit the attention of those interested in this branch of science, I may consider that he has added a mite further to entitle him to the good wishes of those who applaud him for his constant endeavours to promote the general interest of mankind—endeavours which he has shown to extend through Europe and Asia in the cause of humanity, and to be exercised at home in various ways, among which I notice his attention to the practice of Life, Fire, and Marine Assurance; he being the President of the Alliance British and Foreign Life and Fire Assurance Com­pany; of which I was the founding Actuary, and in which Institution, though retired from it, I feel greatly interested; it having been established about the year 1824 by the late N. M. de Rothschild, Esq., the late John Irving, Esq., the late Samuel Gurney, Esq., and Francis Baring, Esq., and himself conjointly with other gentlemen, and he being also President of the Alliance Marine Assurance Society, founded at the same time by them with him. Art. 1. In the year 1820 the Royal Society did me the honour to publish in their Transactions a paper of mine on the Analysis and Notation applicable to the valuation of Life Contingencies, in which I introduced a new and general notation, which appealed to me far more extensively useful, and more explanatory of its object, than any other notation I had met with; and in that paper I think I introduced a new manner of deal­ing with the subject, by offering an analysis, with examples of the extensive use of it, applicable to some of the most intricate questions which had up to that period met with anything like a proper solution; and showed, by selections from the treatise of Life Annuities of my late learned and much-respected friend, Francis Baily, Esq., a mode of solution of all the problems in chapter 8 of that work, depending on a particular order of survivorship; problems previously considered many years before, and presented by my late friend William Morgan, Esq., of the Equitable Society, to the Royal Society, and published in their valuable Transactions; and which had been since considered, in a learned work on Life Annuities, by my late respected friend Joshua Milne, Esq., with some ingenious notation with respect to those contingencies. But still, the solutions given to many of the problems, though there were but three lives con­cerned, were of such an intricate practical form, as to be in my opinion perfectly useless; especially on considering that it was necessary to obtain, by Tables of single and joint lives, by necessary interpolations, the required data; as the differences to be used for the interpolations, in consequence of the great irregularity of the numbers of those Tables, are so irregular as to throw great doubt on the necessary accuracy of the results. And I think the examples I gave of my method could leave no doubt as to the comparative simplicity which resulted from it, and consequently comparative utility of my analysis; an analysis which applies where there are more than three lives concerned, and, in fact, where there are any number of lives to be considered. And I may refer the reader to my solutions in that tract, to enable him to make the com­parison.


1859 ◽  
Vol 9 ◽  
pp. 165-165

The object of the present memoir is the further development of the theory of binary quantics; it should therefore have preceded so much of my third memoir, vol. cxlvii. (1857), p. 627, as relates to ternary quadrics and cubics. The paragraphs are numbered continuously with those of the former memoirs. The first three paragraphs, Nos. 62 to 64, relate to quantics of the general form (*≬ x, y ,..) m , and they are intended to complete the series of definitions and explanations given in Nos. 54 to 61 of my third memoir; Nos. 68 to 71, although introduced in reference to binary quantics, relate or may be considered as relating to quantics of the like general form. But with these exceptions the memoir relates to binary quantics of any order whatever: viz. Nos. 65 to 80 relate to the covariants and invailants of the degrees 2, 3, and 4; Nos. 81 and 82 (which are introduced somewhat parenthetically) contain the explanation of a process for the calculation of the invariant called the discriminant; Nos. 83 to 85 contain the definitions of the catalectieant, the lambdaic and the canonisant, which are functions occurring in Prof. Sylvester’s theory of the reduction of a binary quantic to its canonical form; and Nos. 86 to 91 contain the definitions of certain covariants or other derivatives connected with Bezout’s abbreviated method of elimination, due for the most part to Professor Sylvester, and which are called Bezoutiants, Cobezoutiants, &c. I have not in the present memoir in any wise considered the theories to which the catalecticant &c. and the other covariants and derivatives just referred to relate; the design is to point out and precisely define the different covariants or other derivatives which have hitherto presented themselves in theories relating to binary quantics, and so to complete, as far as may be, the explanation of the terminology of this part of the subject.


1880 ◽  
Vol 30 (200-205) ◽  
pp. 557-560 ◽  

In the course of some experimental investigations into the pathology of anthrax at the Brown Institution, made during the past twelve months, two series of phenomena have been the subject of study, and in each some results which I believe to be novel have been attained. These results have not only a considerable practical importance, if verified by other observers, but their interest in relation to the patho­logy of anthrax and other diseases appears to me sufficient to warrant their communication to the Royal Society in the form of a preliminary note, leaving the full detail of the experiments for a future occasion. The practical purpose of these investigations was to ascertain (1) by what means the virus of splenic fever may be so modified as to be capable of inoculation without fatal result, and (2) whether a modified attack, produced by inoculation, exerts any protective influence against a future inoculation with unmodified virus.


1872 ◽  
Vol 162 ◽  
pp. 283-318 ◽  

In the last memoir which I laid before the Royal Society I described a number of forms of Lepidodendroid plants from the Coal-measures, without making any material attempt to ascertain the relationship which they bore to each other. I now propose to carry the subject somewhat further, and to show that some of these apparently varied forms of Lycopodiaceæ merely represent identical or closely allied plants in different stages of their growth. The discovery of some remarkable beds in Burntisland, by George Grieve, Esq., and his persistent kindness in supplying me abundantly with the raw material upon which I could work, have enabled me to do this in a manner, at least, satisfactory to myself. Upon the geology of these remarkable beds I will not now enter, beyond saying that they appear to have been patches of peat belonging to the lower Burdiehouse series, which are now imbedded in masses of volcanic amygdaloid. The stratum, where unaltered by contact with the lava, is little more than a mass of vegetable fragments, the minute structure of most of which is exquisitely preserved. The more perfect remains that are capable of being identified belong to but few types. The most abundant of these are the young twigs of a Lepidodendron , portions of the stem of a Diploxylon , stems of a remarkable Lycopodiaceous plant belonging to my new genus Dictyoxylon (but which, for reasons to be stated in a future memoir, I propose to unite with Corda’s genus Heterangium , under the name of H. Grievii ), and fragments of Stigmaria-ficoides . Along with these occur, but more rarely, several other curious Lycopodiaceous and Fern stems, and those of an articulated plant, which I believe to be an Asterophyllites ; also some true Lepidostrobous fruits and myriads of caudate macrospores belonging to the Lepidostrobi . The first point to be noted is that all the Lepidodendroid branches are young twigs. No one example of a large stem has been found presenting exactly the same structure as these small branches, which, as already stated, are so abundant. On the other hand, all the Diploxylons are large branches or matured stems. These facts at once suggested the inquiry whether the two plants referred to might not be complementary to each other. A careful and very extended study of a large number of specimens has convinced me that such is the case. I have made more than a hundred sections of the two forms, and the result has been a remarkably clear testimony that the Lepidodendra are the twigs and young branches of the Diploxylon -stems. I am also led to the conclusion that the Lepidostrbi , with their peculiar macrospores and microspores, belong to the same plant. I will examine each of these forms in detail.


1868 ◽  
Vol 16 ◽  
pp. 44-59

The experiments recorded in this paper are intended to complete the inquiry into the effect of rest and exercise on the elimination of nitrogen recorded in the Proceedings of the Royal Society (No. 89, 1867). The experiments were made on two soldiers at the Royal Victoria Hospital at Netley. One of them (S.) was the subject of the former experiments, the other man (B.) was a fresh man. B. is a perfectly healthy temperate man, aged 22½ years, 5 feet 9¼ inches in height, and weighing 140 lbs.


1812 ◽  
Vol 102 ◽  
pp. 238-246 ◽  

The experiments, which form the subject of the following pages, are intended as supplementary to a more extensive series, which the Royal Society did me the honour to insert in their Transactions for the year 1800. Of the general accu­racy of those experiments, I have since had no reason to doubt; and their results, indeed, are coincident with those of subsequent writers of the highest authority in chemistry. My attention has been again drawn to the subject by the impor­tant controversy which has lately been carried on between Mr. Murray and Mr. John Davy respecting the nature of mu­riatic and oxymuriatic acids; and I have been induced, by some hints which the discussion has suggested, not only to repeat the principal experiments described in my memoir, but to institute others, with the advantage of a more perfect appa­ratus than I then possessed, and of greater experience in the management of these delicate processes. This repetition of my former labours has discovered to me an instance, in which I have failed in drawing the proper con­clusion from facts. In two comparative experiments on the electrization of equal quantities of muriatic acid gas, the one of which was dried by muriate of lime, and the other was in its natural state, I found a difference of not more than one percent , in the hydrogen evolved, relatively to the original bulk of the gas. Yet, notwithstanding these results, I have expressed myself inclined to believe that some water is abstracted by that deliquescent salt; and this belief was confirmed, seve­ral years afterwards, by the event of an experiment in which muriatic acid gas, dried by muriate of lime, gave only 1/35 its bulk of hydrogen, a proportion much below the usual ave­rage. The question, however, was too interesting to be left in any degree of uncertainty; and I have, therefore, made several fresh experiments with the view to its decision. In the course of these I have found, that though differences in the results are produced by causes apparently trivial, some of which I shall afterwards point out, yet that under equal circumstances, precisely the same relative proportion of hy­drogene gas is obtained from muriatic acid gas, whether ex­posed or not to muriate of lime; and that its greatest amount does not exceed 1/16 or 1/14 the original volume of the acid gas.


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