scholarly journals Case study: design and implementation of training for scientists deploying to Ebola diagnostic field laboratories in Sierra Leone: October 2014 to February 2016

2017 ◽  
Vol 372 (1721) ◽  
pp. 20160299 ◽  
Author(s):  
Christopher H. Logue ◽  
Suzanna M. Lewis ◽  
Amber Lansley ◽  
Sara Fraser ◽  
Clare Shieber ◽  
...  
Keyword(s):  
International Development ◽  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Training Group ◽  
Lessons Learned ◽  
Epidemiological Surveillance ◽  
Diagnostic Laboratory ◽  
Design And Implementation ◽  
The Uk

As part of the UK response to the 2013–2016 Ebola virus disease (EVD) epidemic in West Africa, Public Health England (PHE) were tasked with establishing three field Ebola virus (EBOV) diagnostic laboratories in Sierra Leone by the UK Department for International Development (DFID). These provided diagnostic support to the Ebola Treatment Centre (ETC) facilities located in Kerry Town, Makeni and Port Loko. The Novel and Dangerous Pathogens (NADP) Training group at PHE, Porton Down, designed and implemented a pre-deployment Ebola diagnostic laboratory training programme for UK volunteer scientists being deployed to the PHE EVD laboratories. Here, we describe the training, workflow and capabilities of these field laboratories for use in response to disease epidemics and in epidemiological surveillance. We discuss the training outcomes, the laboratory outputs, lessons learned and the legacy value of the support provided. We hope this information will assist in the recruitment and training of staff for future responses and in the design and implementation of rapid deployment diagnostic field laboratories for future outbreaks of high consequence pathogens. This article is part of the themed issue ‘The 2013–2016 West African Ebola epidemic: data, decision-making and disease control’.

scholarly journals Implementation of a study to examine the persistence of Ebola virus in the body fluids of Ebola virus disease survivors in Sierra Leone: Methodology and lessons learned

2017 ◽  
Vol 11 (9) ◽  
pp. e0005723 ◽  
Author(s):  
Gibrilla Fadlu Deen ◽  
Suzanna L. R. McDonald ◽  
Jaclyn E. Marrinan ◽  
Foday R. Sesay ◽  
Elizabeth Ervin ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Body Fluids ◽  
Lessons Learned ◽  
The Body ◽  
Ebola Virus Disease

Ebola Virus Disease - clinical manifestations, management and future therapies

2019 ◽  
Vol 105 (2) ◽  
pp. 113-120
Author(s):  
D O’Brien ◽  
M K O’Shea ◽  
T E Fletcher
Keyword(s):  
Ebola Virus ◽  
Virus Disease ◽  
Clinical Manifestations ◽  
Armed Forces ◽  
Lessons Learned ◽  
The Body ◽  
Ebola Virus Disease ◽  
International Response ◽  
The Uk ◽  
Specific Symptoms

AbstractThe largest epidemic of Ebola Virus Disease in recorded human history occurred in West Africa in 2014 and resulted in significant morbidity and mortality. The causative pathogen, Ebola virus, is readily transmitted through contact with the body fluids of infected individuals and from the bodies of those who have died from the disease. In its early stages, the illness is characterised by non-specific symptoms that mimic many other endemic infectious diseases in countries with limited healthcare resources. These factors contributed to the rapid spread of the outbreak, which required an international response in which the UK Armed Forces played an important role. This review describes the clinical presentation, lessons learned from managing the West African outbreak, and potential future treatments.

Nosocomial transmission of Ebola virus disease on pediatric and maternity wards: Bombali and Tonkolili, Sierra Leone, 2014

2016 ◽  
Vol 44 (3) ◽  
pp. 269-272 ◽  
Author(s):  
Angela C. Dunn ◽  
Tiffany A. Walker ◽  
John Redd ◽  
David Sugerman ◽  
Jevon McFadden ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Nosocomial Transmission

scholarly journals The impact of active surveillance and health education on an Ebola virus disease cluster — Kono District, Sierra Leone, 2014–2015

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Tasha Stehling-Ariza ◽  
Alexander Rosewell ◽  
Sahr A. Moiba ◽  
Brima Berthalomew Yorpie ◽  
Kai David Ndomaina ◽  
...  
Keyword(s):  
Health Education ◽  
Sierra Leone ◽  
Active Surveillance ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Disease Cluster ◽  
The Impact ◽  
Kono District

scholarly journals Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone

2017 ◽  
Author(s):  
Nadege Goumkwa Mafopa ◽  
Gianluca Russo ◽  
Raoul Emeric Guetiya Wadoum ◽  
Emmanuel Iwerima ◽  
Vincent Batwala ◽  
...  
Keyword(s):  
Immune Response ◽  
Virus Infection ◽  
West Africa ◽  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Asymptomatic Infection ◽  
Ebola Virus Disease ◽  
Efficient Immune Response ◽  
Ebola Virus Infection

A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient immune response.

scholarly journals Assessment of Community Event–Based Surveillance for Ebola Virus Disease, Sierra Leone, 2015

2016 ◽  
Vol 22 (8) ◽  
pp. 1431-1437 ◽  
Author(s):  
Ruwan Ratnayake ◽  
Samuel J. Crowe ◽  
Joseph Jasperse ◽  
Grayson Privette ◽  
Erin Stone ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease ◽  
Event Based

scholarly journals Clinical Features of Patients With Ebola Virus Disease in Sierra Leone

2015 ◽  
Vol 61 (4) ◽  
pp. 491-495 ◽  
Author(s):  
Enqiang Qin ◽  
Jingfeng Bi ◽  
Min Zhao ◽  
Ye Wang ◽  
Tongsheng Guo ◽  
...  
Keyword(s):  
Sierra Leone ◽  
Clinical Features ◽  
Ebola Virus ◽  
Virus Disease ◽  
Ebola Virus Disease
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