scholarly journals Role of the viaB locus in synthesis, transport and expression of Salmonella typhi Vi antigen

Microbiology ◽  
1995 ◽  
Vol 141 (12) ◽  
pp. 3039-3047 ◽  
Author(s):  
I. Virlogeux ◽  
H. Waxin ◽  
C. Ecobichon ◽  
M. Y. Popoff
Keyword(s):  
Salmonella Typhi ◽  
Vi Antigen

Role of Salmonella Typhi Vi Antigen and Secretory Systems on Immune Response

2016 ◽  
Vol 22 (41) ◽  
pp. 6251-6260 ◽  
Author(s):  
Ermin Schadich ◽  
Petr Dzubak ◽  
Marian Hajduch
Keyword(s):  
Immune Response ◽  
Salmonella Typhi ◽  
Vi Antigen

scholarly journals A New Enzyme-Linked Immunosorbent Assay (ELISA) for Vi Antigen as a Potential Diagnostic for Infections by Salmonella Typhi

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S604-S605
Author(s):  
Christopher A Darlow ◽  
Christina Dold ◽  
Malick M Gibani ◽  
Andrew J Pollard
Keyword(s):  
Immunosorbent Assay ◽  
Salmonella Typhi ◽  
Enzyme Linked Immunosorbent Assay ◽  
Vi Antigen

Immune response to Vi-antigen of Salmonella typhi is dependent on introduction of positive charge and shape of charged group into polysaccharide

2017 ◽  
Vol 473 (1) ◽  
pp. 141-144 ◽  
Author(s):  
A. V. Kolesnikov ◽  
A. V. Kozyr ◽  
A. K. Ryabko ◽  
I. G. Shemyakin ◽  
I. A. Dyatlov
Keyword(s):  
Immune Response ◽  
Positive Charge ◽  
Salmonella Typhi ◽  
Charged Group ◽  
Vi Antigen

scholarly journals Emergence and molecular basis of azithromycin resistance in typhoidal Salmonella in Dhaka, Bangladesh

2019 ◽  
Author(s):  
Yogesh Hooda ◽  
Senjuti Saha ◽  
Mohammad S I Sajib ◽  
Hafizur Rahman ◽  
Stephen P Luby ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Single Point ◽  
Salmonella Typhi ◽  
Oral Drug ◽  
Single Point Mutation ◽  
E Coli ◽  
Vaccine Introduction ◽  
Rnd Efflux Pump ◽  
Azithromycin Resistance

With rising fluoroquinolone and ceftriaxone-resistant Salmonella Typhi, azithromycin, a macrolide, has become the last oral drug available against typhoid. Between 2009-2016, we isolated 1,082 Salmonella Typhi and Paratyphi A strains in Bangladesh, 13 (12 Typhi and 1 Paratyphi A) of which were azithromycin-resistant. When compared to 462 previously sequenced Typhi strains, the genomes of the 12 azithromycin-resistant Typhi strains (4.3.1 sub-clade, H58) harbored an exclusive non-synonymous single-point mutation R717Q in AcrB, an RND-efflux pump. Expression of AcrB-R717Q in E. coli and Typhi strains increased its minimum inhibitory concentration (MIC) for azithromycin by 11- and 3-fold respectively. The azithromycin-resistant Paratyphi A strain also contained a mutation at R717 (R717L), whose introduction in E. coli and Paratyphi A strains increased MIC by 7- and 3-fold respectively, confirming the role of R717 mutations in conferring azithromycin resistance. With increasing azithromycin use, strains with R717 mutations may spread leading to treatment failures, making antibiotic stewardship and vaccine introduction imperative.

scholarly journals Enzyme-linked immunosorbent assay for detection of human antibodies to Salmonella typhi Vi antigen.

1983 ◽  
Vol 17 (4) ◽  
pp. 625-627 ◽  
Author(s):  
T J Barrett ◽  
P A Blake ◽  
S L Brown ◽  
K Hoffman ◽  
J M Llort ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Salmonella Typhi ◽  
Enzyme Linked Immunosorbent Assay ◽  
Human Antibodies ◽  
Vi Antigen

scholarly journals Adsorption of Vi Capsular Antigen of Salmonella Typhi in Chitosan–Poly (Methacrylic Acid) Nanoparticles

Polymers ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1226
Author(s):  
Raimundo Lopes da Silva ◽  
Jaqueline Rodrigues da Silva ◽  
Anivaldo Pereira Duarte Júnior ◽  
Patrícia Santana Barbosa Marinho ◽  
Lourivaldo Silva Santos ◽  
...  
Keyword(s):  
Adsorption Kinetics ◽  
Methacrylic Acid ◽  
Capsular Polysaccharide ◽  
Phosphate Buffer Solution ◽  
Salmonella Typhi ◽  
Buffer Solution ◽  
Transmission Microscopy ◽  
Capsular Antigen ◽  
Antigen Structure ◽  
Vi Antigen

The development of a nanoparticulate system for the carrier antigen is now an important tool in the vaccination process, since a smaller number of doses is necessary for effective immunization. Thus, in this work a nanoparticulate system using polymers of chitosan and poly (methacrylic acid) (CS–PMAA) to adsorb the Vi antigen of Salmonella Typhi was developed. CS–PMAA nanoparticles with different proportions of chitosan and poly (methacrylic acid) were obtained and reached sizes from 123.9 ± 2.48 to 234.9 ± 2.66 nm, and spherical shapes were seen in transmission microscopy. At pH 7.2, the nanoparticles had a cationic surface charge that contributed to the adsorption of the Vi antigen. Qualitative analyses of the isolated Vi antigen were performed using Fourier-transform infrared spectroscopy, which indicated the presence of all the characteristic bands of the capsular polysaccharide, and nuclear magnetic resonance, which showed signals for the five hydrogens and the N-acetyl and O-acetyl groups which are characteristic of the Vi antigen structure. In the adsorption kinetics study, the Vi capsular antigen, contained in a phosphate buffer solution of pH 7.2, experienced 55% adsorption on the 1–1% (CS–PMAA) nanoparticles. The adsorption kinetics results showed the ability of the nanoparticulate system to adsorb the Vi antigen.

Role of Vi Antigen in Salmonella paratyphi C Infections

1959 ◽  
Vol 100 (3) ◽  
pp. 653-656 ◽  
Author(s):  
A. D. Mandel ◽  
L. S. Baron ◽  
C. E. Buckler
Keyword(s):  
Vi Antigen
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